2-methyl-2-(5-hexen-1-yne-3,6-diphenyl-1-yl)-1-phenylaziridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-methyl-2-(5-hexen-1-yne-3,6-diphenyl-1-yl)-1-phenylaziridine
• 英文别名: 2-[(E)-3,6-diphenylhex-5-en-1-ynyl]-2-methyl-1-phenylaziridine
• 化学式: C₂₇H₂₅N
• 分子量: 363.502
• InChiKey: ABHVGSSVLAYBPG-SDNWHVSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  肉桂基氯 、 alkaline earth salt of/the/ methylsulfuric acid 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.0h， 生成 2-methyl-2-(5-hexen-1-yne-3,6-diphenyl-1-yl)-1-phenylaziridine
  参考文献：
  名称：

  Lithiation of Cinnamyl Chloride: Stereoselective Synthesis of Propargylic Oxiranes and Aziridines

  摘要：

  Propargylic oxiranes 4a-e and aziridines 8a-c have been prepared from cinnamyl chloride through lithiation-alkylation with alpha -halo carbonyl compounds and alpha -chloro imines, respectively. The reaction with substituted alpha -halo carbonyl compounds and alpha -chloro imines proved to be highly E diastereoselective.

  DOI：

  10.1002/1099-0690(200011)2000:22<3793::aid-ejoc3793>3.0.co;2-m

文献信息

• Lithiation of Cinnamyl Chloride: Stereoselective Synthesis of Propargylic Oxiranes and Aziridines
  作者：Saverio Florio、Luigino Troisi、Vito Capriati、Giovanna Suppa

  DOI：10.1002/1099-0690(200011)2000:22<3793::aid-ejoc3793>3.0.co;2-m

  日期：2000.11

  Propargylic oxiranes 4a-e and aziridines 8a-c have been prepared from cinnamyl chloride through lithiation-alkylation with alpha -halo carbonyl compounds and alpha -chloro imines, respectively. The reaction with substituted alpha -halo carbonyl compounds and alpha -chloro imines proved to be highly E diastereoselective.