三(2-甲氧基苯基)亚磷酸酯 | 36370-75-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 三(2-甲氧基苯基)亚磷酸酯
• 英文名称: tris(2-methoxyphenyl)phosphite
• 英文别名: Tris(2-methoxyphenyl) phosphite
• CAS: 36370-75-9
• 化学式: C₂₁H₂₁O₆P
• 分子量: 400.368
• InChiKey: ZEAQEZGTGCQGBN-UHFFFAOYSA-N

物化性质

• 熔点：
  63-67 °C
• 沸点：
  472.6±40.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  三(2-甲氧基苯基)亚磷酸酯 以 乙醚 、 二氯甲烷 、 二氯甲烷-D2 为溶剂， 生成 carbanide;platinum(2+);tris(2-methoxyphenyl) phosphite;tetrafluoroborate;hydrate
  参考文献：
  名称：

  Tris(2-methoxyphenyl) phosphite complexes of platinum(II): the cis preference of triaryl phosphite ligands and the effect of oxidation state on metal–phosphite bonding

  摘要：

  The complexes cis-[PtX(2){P(OC(6)H(4)OMe-2)(3)}(2)] (X = Cl, Br or I) have been prepared by treatment of the corresponding [PtX(2)(cod)] (cod = cycloocta-1,5-diene) with P(OC(6)H(4)OMe-2)(3). That with X = Cl reacted with 1 or 2 equivalents of SnCl2 to give cis-[PtCl(SnCl3){P(OC(6)H(4)OMe-2)(3)}(2)] or trans-[Pt(SnCl3)2{P(OC(6)H(4)OMe-2)(3)}(2)]. The unstable hydride trans-[PtH(Cl){P(OC(6)H(4)OMe-2)(3)}(2)] was detected when cis-[PtCl2{P(OC(6)H(4)OMe-2)(3)}(2)] was treated with NaBH4 or [Pt{P(OC(6)H(4)OMe-2)(3)}(3)] with HCl. The organoplatinum complexes cis-[PtR(2){P(OC(6)H(4)OMe-2)(3)}(2)] and cis-[PtR(X){P(OC(6)H(4)OMe-2)(3)}(2)] (R = Me, X = Cl, I or CN; R = Et, X = Cl) were obtained from platinum-(II) and -(0) precursors. Addition of HBF4 to cis-[PtMe(2){P(OC(6)H(4)OMe-2)(3)}(2)], in the presence of H2O or MeCN, gave the cationic species cis-[PtMe(L){P(OC(6)H(4)OMe-2)(3)}(2)][BF4] (L = H2O or MeCN). The significance of the observation that complexes of the type [PtMe(L){P(OC(6)H(4)OMe-2)(3)}(2)] are invariably cis is discussed. The crystal structures of cis-[PtCl2{P(OC(6)H(4)OMe-2)(3)}(2)] and cis-[PtMe(OH2){P(OC(6)H(4)OMe-2)(3)}(2)][BF4]. CH2Cl2 have been determined. These, together with those previously reported for P(OC(6)H(4)OMe-2)(3) and [Pt(eta-C2H4){P(OC(6)H(4)OMe-2)(3)}(2)], show pronounced variation in P-O lengths and O-P-O bond angles consistent with the greater importance of Pt-P pi bonding in the platinum(0) species. The phosphite P(OC(6)H(4)OMe-2)(3) shows a range of conformations in the structures and that with anti, gauche, gauche (agg) conformation about the P-O bonds apparently favoured in general but ggg attainable in the absence of steric crowding. In cis-[PtMe(OH2){P(OC(6)H(4)OMe-2)(3)}(2)][BF4]. CH2Cl2, intramolecular hydrogen bonding leads to an unusual aag conformation. Weak Pt...O interactions involving the OMe groups of the phosphite ligand are observed in these structures. The correlation of P-O length and O-P-O angle variation is mirrored by similar behaviour for 133 Z-P(OPh)(3) (Z = O, N or metal) structures. These observations are consistent with the now conventional view of M-P pi bonding.

  DOI：

  10.1039/dt9960001069
• 作为产物：
  描述：

  木榴油 在 三乙胺 、 三氯化磷 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以84%的产率得到三(2-甲氧基苯基)亚磷酸酯
  参考文献：
  名称：

  Ni催化区域选择性β,δ-二芳基化酮亚胺中未活化的烯烃通过配体启用的瞬态镍环收缩：快速获得远程二芳基化酮

  摘要：

  我们公开了 [(PhO)3P]/NiBr2 催化的区域选择性 β,δ-二芳基化酮亚胺中未活化的烯烃与芳基卤化物和芳基锌试剂。这种二芳基化作用在偏远的位置进行到羰基，经过简单的 H+ 处理后，可以得到多种取代的 β,δ-二芳基酮，而这些酮很难用现有方法轻松获得。氘标记和交叉实验表明二芳基化是通过配体启用的瞬态镍环收缩进行的。

  DOI：

  10.1021/jacs.8b03163

文献信息

• Diphenyl Diselenide-Catalyzed Synthesis of Triaryl Phosphites and Triaryl Phosphates from White Phosphorus
  作者：Yue Zhang、Ziman Cai、Yangyang Chi、Xiangzhe Zeng、Shuanghui Chen、Yan Liu、Guo Tang、Yufen Zhao

  DOI：10.1021/acs.orglett.1c01695

  日期：2021.7.2

  Industrially important triaryl phosphites, traditionally prepared from PCl3, have been synthesized by a diphenyl diselenide-catalyzed one-step procedure involving white phosphorus and phenols, which provides a halogen- and transition metal-free way to these compounds. Subsequent oxidation of triaryl phosphites produces triaryl phosphates and triaryl thiophosphates. Phosphorotrithioates are also prepared

  工业上重要的亚磷酸三芳基酯，传统上由 PCl 3制备，已通过涉及白磷和苯酚的二苯基二硒化物催化一步法合成，这为这些化合物提供了一种不含卤素和过渡金属的方法。随后亚磷酸三芳基酯氧化产生磷酸三芳基酯和硫代磷酸三芳基酯。三硫代磷酸酯也可以由芳香族硫醇和脂肪族硫醇有效地制备。
• Aortic Distensibility is Closely Related to the Progression of Left Ventricular Hypertrophy in Patients Receiving Hemodialysis
  作者：Yuji Matsumoto、Mareomi Hamada、Kunio Hiwada

  DOI：10.1177/000331970005101106

  日期：2000.11

  Aortic stiffening and left ventricular hypertrophy are believed to be major determinants for the prognosis of patients with end-stage renal disease. However, the relationship between left ventricular hypertrophy and aortic stiffness remains to be determined. Echocardiographically determined parameters and aortic distensibility determined with cine magnetic resonance were evaluated in 21 patients undergoing chronic hemodial ysis. Hemodynamic variables measured at the beginning of the study were compared with those measured after 28 months. Aortic distensibility determined at the descending aorta was markedly lower in patients undergoing hemodialysis than in healthy control subjects. During the follow-up period, blood pressure and hemodynamic variables, including left ventricular mass index, remained unchanged. However, multiple regression analysis indicated that aortic distensibility independently contributed to the left ventric ular mass index and to the change in left ventricular mass index between baseline and after 28 months. Baseline left ventricular mass index negatively correlated to aortic distensibility ( r = -0.74, p < 0.0001), and the changes in left ventricular mass index posi tively correlated to aortic distensibility ( r = 0.52, p < 0.05). Our study demonstrates that aortic distensibility at the descending aorta is a predictable marker for the development or regression of left ventricular hypertrophy. Therefore, patients with end-stage renal disease must be treated with appropriate drugs to improve aortic distensibility.

  主动脉硬化和左心室肥厚被认为是影响终末期肾病患者预后的主要因素。然而，左心室肥厚与主动脉僵硬之间的关系尚待确定。在进行慢性血液透析的21名患者中，通过超声心动图测定的参数和磁共振电影测定的主动脉扩张性进行评估。研究开始时测量的血流动力学变量与28个月后测量的变量进行比较。在进行血液透析的患者中，降主动脉的主动脉扩张性明显低于健康对照组。在随访期间，血压和血流动力学变量，包括左心室质量指数，保持不变。然而，多元回归分析表明，主动脉扩张性独立地对左心室质量指数以及基线和28个月后左心室质量指数的变化做出了贡献。基线左心室质量指数与主动脉扩张性呈负相关（r = -0.74，p < 0.0001），左心室质量指数变化与主动脉扩张性呈正相关（r = 0.52，p < 0.05）。我们的研究表明，降主动脉的主动脉扩张性是左心室肥厚发展或退化的可预测标志。因此，必须给予终末期肾病患者适当的药物治疗以改善主动脉扩张性。
• 2-Methoxyphenyl phosphite complexes of platinum(0) and nickel(0)
  作者：Michael J. Baker、Karl N. Harrison、A. Guy Orpen、Paul G. Pringle、Gordon Shaw

  DOI：10.1039/dt9920002607

  日期：——

  e-4)2 have been prepared. The platinum(0) complex [PtP(OC6H4OMe-2)3}3]1 can be made by the reduction of [PtCl2P(OC6H4OMe-2)3}2] in the presence of the phosphite or by addition of the latter to tris(η2-norbornene)platinum, and [Pt(η2-C2H4)P(OC6H4OMe-2)3}2]2 by the reduction of [PtCl2P(OC6H4OMe-2)3}2] in the presence of ethene or by adding of the phosphite to [Pt(η2-C2H4)3]. The crystal structures

  已经制备了化合物P（OC 6 H 4 OMe-2）3和P（OC 6 H 4 OMe-2）（OC 6 H 4 Me-4）2。铂（0）络合物[Pt P（OC 6 H 4 OMe-2）3 } 3 ] 1可以通过还原[PtCl 2 P（OC 6 H 4 OMe-2）3 } 2 ]来制备。亚磷酸酯的或通过加入后者以三（η存在2降冰片烯）铂，和[PT（η 2 -C2 H 4）P（OC 6 H 4 OMe-2） 3 } 2 ] 2通过在乙烯存在下还原[PtCl 2 P（OC 6 H 4 OMe-2） 3 } 2 ]或通过添加亚磷酸酯至[PT（η 2 -C 2 H ^ 4） 3 ]。配体P（OC 6 H 4 OMe-2） 3和配合物2的晶体结构已经确定了配位作用，并讨论了配位作用对亚磷酸酯取代基构象的影响。在乙烯配体2可容易地通过其它烯烃和炔烃取代的，得到的复合物3 - 9的一般类型的[PT（η 2
• Selective Hydrogenation Catalyst and Methods of Making and Using Same
  申请人：Cheung Tin-Tack Peter

  公开号：US20100228065A1

  公开（公告）日：2010-09-09

  A composition comprising a supported hydrogenation catalyst comprising palladium and an organophosphorous compound, the supported hydrogenation catalyst being capable of selectively hydrogenating highly unsaturated hydrocarbons to unsaturated hydrocarbons. A method of making a selective hydrogenation catalyst comprising contacting a support with a palladium-containing compound to form a palladium supported composition, contacting the palladium supported composition with an organophosphorus compound to form a catalyst precursor, and reducing the catalyst precursor to form the catalyst. A method of selectively hydrogenating highly unsaturated hydrocarbons to an unsaturated hydrocarbon enriched composition comprising contacting a supported catalyst comprising palladium and an organophosphorous compound with a feed comprising highly unsaturated hydrocarbon under conditions suitable for hydrogenating at least a portion of the highly unsaturated hydrocarbon feed to form the unsaturated hydrocarbon enriched composition.

  一种包括支持的氢化催化剂的组合物，其中氢化催化剂包括钯和有机磷化合物，支持的氢化催化剂能够选择性地将高度不饱和烃氢化为不饱和烃。一种制备选择性氢化催化剂的方法，包括将支持物与含钯化合物接触以形成支持的钯组合物，将支持的钯组合物与有机磷化合物接触以形成催化剂前体，并还原催化剂前体以形成催化剂。一种将高度不饱和烃选择性氢化为富含不饱和烃的组合物的方法，包括将包括钯和有机磷化合物的支持催化剂与含高度不饱和烃的进料接触，在适宜的氢化条件下至少部分氢化高度不饱和烃进料以形成富含不饱和烃的组合物。
• [EN] PROCESS FOR PREPARING DIARYL ALKYLPHOSPHONATES AND OLIGOMERIC/POLYMERIC DERIVATIVES THEREOF<br/>[FR] PROCEDE POUR PREPARER DES DIARYL ALKYL PHOSPHONATES, ET DES DERIVES OLIGOMERES/POLYMERES CORRESPONDANTS
  申请人：SUPRESTA LLC

  公开号：WO2006026616A1

  公开（公告）日：2006-03-09

  A process is provided for the production of diaryl alkyl phosphonate by the reaction of triaryl phosphate with dialkyl alkyl phosphonate in the presence of alkali metal iodide catalyst; and, optionally, the diaryl alkyl phosphonate is reacted in situ with aromatic diol and, optionally, with at least one branching monomer, in the absence of other or further added catalyst to provide oligomeric and/or polymeric phosphonate products.

  本发明提供了一种生产二芳基烷基膦酸酯的方法，其中三芳基磷酸酯与二烷基烷基膦酸酯在碱金属碘化物催化剂的存在下反应；并且，在无其他或进一步添加催化剂的情况下，可选地在原位与芳香族二醇反应，以及可选地与至少一种分支单体反应，以提供寡聚物和/或聚合物膦酸酯产品。