bis(6-hydroxyhexyl) carbonate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: bis(6-hydroxyhexyl) carbonate
• 英文别名: 6-hydroxyhexyl carbonate；Di(6-hydroxyhexyl) carbonate
• 化学式: C₁₃H₂₆O₅
• 分子量: 262.346
• InChiKey: ABTFNGBNTJJMJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,6-己二醇 、 二氧化碳 在 cerium(IV) oxide 作用下， 以 二苯醚 、 三甘醇二甲醚 为溶剂， 反应 48.0h， 生成 bis(6-hydroxyhexyl) carbonate
  参考文献：
  名称：

  在不使用脱水剂的情况下，由常压二氧化碳和二醇直接合成聚碳酸酯二醇

  摘要：

  从绿色化学的角度来看，以 CO 2作为 C1 化学品的聚合物合成已引起广泛关注。CO 2和二醇直接转化为聚碳酸酯二醇有望作为危险的光气工艺的替代方法，但是，由于 CO 2的惰性特性和热力学限制，具有挑战性。在此，我们介绍了使用非均相 CeO 2催化剂和 CO 2流半间歇反应器从常压 CO 2和 α,ω-二醇直接合成聚碳酸酯二醇。来自 CO 2的目标交替聚碳酸酯二醇并且在不使用任何脱水剂的情况下以高产率（92%）和选择性（97%）获得了1,6-己二醇。通过CeO 2催化剂活化大气压CO 2以及通过去除联产水（气提）使平衡向产物移动是高产率的原因。带有CeO 2催化剂的流动反应体系适用于CO 2与伯一元醇或1,2-二醇的反应，以高选择性(>99%)得到目标有机碳酸酯。

  DOI：

  10.1039/d1gc01172c

文献信息

• METHODS AND COMPOSITIONS FOR MAKING AN AMINO ACID TRIISOCYANATE
  申请人：Warsaw Orthopedic, Inc.

  公开号：US20150197488A1

  公开（公告）日：2015-07-16

  A method of making an amino acid triisocyanate is provided, the method comprising reacting an amino acid trihydrochloride with phosgene to form the amino acid triisocyanate. In some embodiments, the amino acid trihydrochloride comprises lysine ester trihydrochloride salt and the amino acid triisocyanate comprises lysine ester triisocyanate. In some embodiments, there is a lysine ester triisocyanate having a purity of at least about 98%, the lysine ester triisocyanate having a structure resulting from reacting lysine ester trihydrochloride salt with phosgene to form the lysine ester triisocyanate. These lysine ester triisocyanates can be used to make biodegradable polyurethanes.

  提供了一种制备氨基酸三异氰酸酯的方法，该方法包括将氨基酸三氢氯酸盐与光气反应以形成氨基酸三异氰酸酯。在一些实施例中，氨基酸三氢氯酸盐包括赖氨酸酯三氢氯酸盐，而氨基酸三异氰酸酯包括赖氨酸酯三异氰酸酯。在一些实施例中，存在一种纯度至少约为98%的赖氨酸酯三异氰酸酯，该赖氨酸酯三异氰酸酯具有由赖氨酸酯三氢氯酸盐与光气反应形成赖氨酸酯三异氰酸酯的结构。这些赖氨酸酯三异氰酸酯可用于制造生物降解聚氨酯。
• METHODS AND COMPOSITIONS FOR MAKING AN AMINO ACID TRIHYDROCHLORIDE
  申请人：Warsaw Orthopedic, Inc.

  公开号：US20150197483A1

  公开（公告）日：2015-07-16

  In some embodiments, a method of making an amino acid trihydrochloride is provided, the method comprising reacting an amino acid monohydrochloride with an alkanolamine to form the amino acid trihydrochloride. In some embodiments, the amino acid monohydrochloride comprises lysine hydrochloride, which is mixed with ethanolamine to form lysine ester trihydrochloride. In some embodiments, there is a lysine ester trihydrochloride salt having a purity of at least about 98%, the lysine ester trihydrochloride salt having a structure resulting from reacting lysine hydrochloride and ethanolamine to form the lysine ester trihydrochloride salt. The lysine ester trihydrochloride can be made in one reaction vessel.

  在某些实施例中，提供了一种制备氨基酸三氢氯化物的方法，该方法包括将氨基酸单氢氯化物与烷醇胺反应以形成氨基酸三氢氯化物。在某些实施例中，氨基酸单氢氯化物包括赖氨酸盐酸盐，其与乙醇胺混合以形成赖氨酸酯三氢氯化物。在某些实施例中，存在一种纯度至少约98%的赖氨酸酯三氢氯化物盐，该赖氨酸酯三氢氯化物盐具有由赖氨酸盐酸盐和乙醇胺反应形成赖氨酸酯三氢氯化物盐的结构。赖氨酸酯三氢氯化物可以在一个反应容器中制造。
• Biodegradable polyurethanes and use thereof
  申请人：Beckman J. Eric

  公开号：US20050013793A1

  公开（公告）日：2005-01-20

  A biodegradable and biocompatible polyurethane composition synthesized by reacting isocyanate groups of at least one multifunctional isocyanate compound with at least one bioactive agent having at least one reactive group —X which is a hydroxyl group (—OH) or an amine group (—NH 2 ). The polyurethane composition is biodegradable within a living organism to biocompatible degradation products including the bioactive agent. Preferably, the released bioactive agent affects at least one of biological activity or chemical activity in the host organism. A biodegradable polyurethane composition includes hard segments and soft segments. Each of the hard segments is preferably derived from a diurea diol or a diester diol and is preferably biodegradable into biomolecule degradation products or into biomolecule degradation products and a biocompatible diol. Another biodegradable polyurethane composition includes hard segments and soft segments. Each of the hard segments is derived from a diurethane diol and is biodegradable into biomolecule degradation products.

  一种可生物降解且生物相容的聚氨酯组合物，通过将至少一个多官能异氰酸酯化合物的异氰酸基与至少一个具有至少一个反应性基团—X的生物活性剂反应合成，其中反应性基团—X是一个羟基（—OH）或胺基（—NH2）。该聚氨酯组合物在生物体内可生物降解为生物相容的降解产物，包括生物活性剂。最好释放的生物活性剂影响寄主生物体中的生物活性或化学活性之一。可生物降解的聚氨酯组合物包括硬段和软段。每个硬段最好来源于二脲二醇或二酯二醇，并且最好生物降解为生物分子降解产物或生物分子降解产物和生物相容的二醇。另一种可生物降解的聚氨酯组合物包括硬段和软段。每个硬段来源于二氨基醚二醇，并且可生物降解为生物分子降解产物。
• NOVEL POLYMERIC PHOTOINITIATORS AND PHOTOINITIATOR MONOMERS
  申请人：Coloplast A/S

  公开号：US20150148441A1

  公开（公告）日：2015-05-28

  The present invention provides polymeric photoinitiators being co-polymers of photoinitiator monomers and at least one further monomer, as well as photoinitiator monomers being intermediates in the preparation of such polymeric photoinitiators. Additionally, there is provided polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety, a hydrolytic stable linker and two polymerisable functional groups are incorporated into the photoinitiator structure.

  本发明提供了聚合物光引发剂，其为光引发剂单体与至少一种进一步单体的共聚物，以及作为这种聚合物光引发剂制备过程中的中间体的光引发剂单体。此外，还提供了通过在存在这种聚合物光引发剂的情况下，通过至少一种丙烯酸酯单体（Ac）的自由基聚合得到的聚丙烯酸酯。在光引发剂单体和聚合物光引发剂中，光引发剂基团、水解稳定连接物和两个可聚合功能基团被结合到光引发剂结构中。
• FLUORINATED ETHER URETHANES AND METHODS OF USING THE SAME
  申请人：Dams Rudolf J.

  公开号：US20110232530A1

  公开（公告）日：2011-09-29

  Compounds comprising end groups represented by formula (Rf-Q) a -X-(A-) b and compounds comprising the reaction product of components comprising a multifunctional isocyanate compound and a fluorinated compound represented by formula (Rf-Q) a -X—(Z) b . Each Rf is independently a partially fluorinated or fully fluorinated group selected from Rf A (O) 2 CHL′-(CF 2 ) n —; [Rf B —(O) 1 —C(L)H—CF 2 —O] m —W—; CF 3 CFH—O—(CF 2 ) p —; CF 3 —(O—CF 2 )Z—; and CF 3 —O—(CF 2 ) 3 —O—CF—. Methods of making an article having a surface using the fluorinated compounds and treated articles are also disclosed.

  本文描述了由式(Rf-Q)a-X-(A-)b表示的末端基团组成的化合物以及由多功能异氰酸酯化合物和式(Rf-Q)a-X—(Z)b表示的氟化合物反应产物组成的化合物。其中，每个Rf都是独立的部分氟化或完全氟化的基团，选自RfA(O)2CHL′-(CF2)n—; [RfB—(O)1—C(L)H—CF2—O]m—W—; CF3CFH—O—(CF2)p—; CF3—(O—CF2)Z—; 和 CF3—O—(CF2)3—O—CF—。还公开了使用这些氟化合物制备具有表面的物品的方法和处理过的物品。