(S)-benzyl 3-hydroxyhexadecanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (S)-benzyl 3-hydroxyhexadecanoate
• 英文别名: benzyl 3-hydroxyhexadecanoate
• 化学式: C₂₃H₃₈O₃
• 分子量: 362.553
• InChiKey: ABYXDTXQWMILCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  26
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-羟基十六酸 、 溴甲苯 在 三乙胺 作用下， 以 水 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 生成 (S)-benzyl 3-hydroxyhexadecanoate
  参考文献：
  名称：

  EP967222

  摘要：

  公开号：

文献信息

• Amino acid derivatives and their use as phospholipase A.sub.2 inhibitor
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US06110933A1

  公开（公告）日：2000-08-29

  The present invention relates to a novel fatty acid derivative of the following formula: ##STR1## wherein R.sup.1 is acyl group, etc.; R.sup.2 is acyl(lower)alkyl; R.sup.3 is lower alkyl, etc.; R.sup.4 is hydrogen, etc.; and X is --O--, etc; and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.

  本发明涉及以下结构的新型脂肪酸衍生物：其中R.sup.1是酰基，等等；R.sup.2是酰(较低)烷基；R.sup.3是较低烷基，等等；R.sup.4是氢，等等；X是--O--，等等；以及其药学上可接受的盐，其作为药物有用；制备所述脂肪酸衍生物或其盐的方法；包含所述脂肪酸衍生物或其药学上可接受的盐的药物组合物；等等。
• Cyclic depsipeptides and drugs containing the same as the active ingredient
  申请人：Yanai Makoto

  公开号：US06858585B1

  公开（公告）日：2005-02-22

  Cyclic depsipeptides represented by the formula wherein: R is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15-carbon atoms; A, B, D, E and F independently each other are alanine, valine, leucine, isoleucine, phenylalanine, etc.; W and Z independently each other are aspartic acid, asparagine, glutamic acid or glutamine; and m and n independently each other is 0 or 1, or pharmacologically acceptable salts thereof. The present compounds are prepared according to a method conventionally used in peptide synthesis. The present compounds are useful as an agent for promoting the production of apolipoprotein E, a therapeutic agent for neurologic damages, a therapeutic agent for dementia, an agent for inhibiting the production of apolipoprotein B, an agent for promoting the production of apolipoprotein A1 or a therapeutic agent for hyperlipemia.

  公式表示的环状脱氢肽类化合物，其中：R是直链或支链烷基，其碳原子数为5-20，或直链或支链烷氧甲基，其碳原子数为5-15；A、B、D、E和F各自独立地是丙氨酸、缬氨酸、亮氨酸、异亮氨酸、苯丙氨酸等；W和Z各自独立地是天冬氨酸、天冬酰胺、谷氨酸或谷氨酰胺；m和n各自独立地为0或1，或其药学上可接受的盐。该化合物是通过肽合成中常规方法制备而成。该化合物可用作促进载脂蛋白E生产的药物，治疗神经损伤的药物，治疗痴呆症的药物，抑制载脂蛋白B生产的药物，促进载脂蛋白A1生产的药物或治疗高脂血症的药物。
• CYCLIC DEPSIPEPTIDES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：Nisshin Flour Milling Co., Ltd.

  公开号：EP0967222A1

  公开（公告）日：1999-12-29

  Cyclic depsipeptides represented by the formula (1) (wherein: R is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; A, B, D, E and F independently each other are alanine, valine, leucine, isoleucine, phenylalanine, etc.; W and Z independently each other are aspartic acid, asparagine, glutamic acid or glutamine; and m and n independently each other is 0 or 1) or pharmacologically acceptable salts thereof. The present compounds are prepared according to a method conventionally used in peptide synthesis. The present compounds are useful as an agent for promoting the production of apolipoprotein E, a therapeutic agent for neurologic damages, a therapeutic agent for dementia, an agent for inhibiting the production of apolipoprotein B, an agent for promoting the production of apolipoprotein A1 or a therapeutic agent for hyperlipemia.

  由式(1)代表的环状去肽类化合物 其中 R是5-20个碳原子的直链或支链烷基或5-15个碳原子的直链或支链烷氧基甲基；A、B、D、E和F各自独立地为丙氨酸、缬氨酸、亮氨酸、异亮氨酸、苯丙氨酸等；W和Z各自独立地为天冬氨酸、天冬酰胺、谷氨酸或谷氨酰胺；m和n各自独立地为0或1）或其药理学上可接受的盐。本化合物是按照肽合成的常规方法制备的。本化合物可用作促进脂蛋白 E 生成的制剂、神经损伤的治疗剂、痴呆症的治疗剂、抑制脂蛋白 B 生成的制剂、促进脂蛋白 A1 生成的制剂或高血脂症的治疗剂。
• US6858585B1
  申请人：——

  公开号：US6858585B1

  公开（公告）日：2005-02-22