daminin

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: daminin
• 英文别名: 1-[2-(1H-pyrrole-2-carbonyloxy)ethyl]pyridin-1-ium-3-carboxylate
• 化学式: C₁₃H₁₂N₂O₄
• 分子量: 260.249
• InChiKey: ACUMEVBOTRCLRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  86.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  烟酸甲酯 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 2.5h， 生成 daminin
  参考文献：
  名称：

  Daminin, a bioactive pyrrole alkaloid from the Mediterranean sponge Axinella damicornis

  摘要：

  The isolation and characterization of the known pyrrole alkaloid agelongine (6) and of the new natural product daminin (7), the bromine-free analogue of 6, from a specimen of the marine sponge Axinella damicornis is described. Compound 7 showed significant neuroprotective properties. Moreover, for the supply of sufficient material for future medicinal investigations, a short total synthesis of 7 was developed. (c) 2005 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2005.05.025

文献信息

• Daminin, a bioactive pyrrole alkaloid from the Mediterranean sponge Axinella damicornis
  作者：Anna Aiello、Monica D'Esposito、Ernesto Fattorusso、Marialuisa Menna、Werner E.G. Müller、Sanja Perović-Ottstadt、Hideyuki Tsuruta、Tobias A.M. Gulder、Gerhard Bringmann

  DOI：10.1016/j.tet.2005.05.025

  日期：2005.7

  The isolation and characterization of the known pyrrole alkaloid agelongine (6) and of the new natural product daminin (7), the bromine-free analogue of 6, from a specimen of the marine sponge Axinella damicornis is described. Compound 7 showed significant neuroprotective properties. Moreover, for the supply of sufficient material for future medicinal investigations, a short total synthesis of 7 was developed. (c) 2005 Published by Elsevier Ltd.