1-tert-Butyl-5-methyl-1H-pyrazole-3-carboxylic acid methyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-tert-Butyl-5-methyl-1H-pyrazole-3-carboxylic acid methyl ester
• 英文别名: Methyl 1-tert-butyl-5-methylpyrazole-3-carboxylate
• 化学式: C₁₀H₁₆N₂O₂
• 分子量: 196.249
• InChiKey: ADZVVWUUFSHYQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-methoxy-2,5-dimethyl-5-(1,1-diphenylmethyl)-Δ³-1,3,4-oxadiazoline 、 丙炔酸甲酯 以 氘代甲醇 为溶剂， 反应 6.0h， 以24%的产率得到5-甲基吡唑-3-甲酸甲酯
  参考文献：
  名称：

  Studies of thermal rearrangements of methyl 3-alkyl-3-methyl-3H-pyrazole-5-carboxylates. Concerted, stepwise, and unclassified mechanisms

  摘要：

  Studies of the thermal rearrangements of five 3H-pyrazoles are described, in which the migrating groups were methoxymethyl, tert-butyl, 1-adamantyl, p-methoxybenzyl, and benzyl. On the basis of reaction products, rearrangement of the (methoxymethyl)pyrazole in benzene, dichloromethane, and methanol at room temperature occurs by a stepwise mechanism, involving discrete ion-pair intermediates. Observed first-order rate constants, for the rearrangement of four of the 3H-pyrazoles in benzene-d(6) and acetone-d(6) at higher temperatures, were determined The tert-butyl compound also rearranges by a stepwise mechanism in benzene d(6), acetone-d(6), and methanol-d(4) based on the fact that isobutene and tert-butyl methyl ether (in methanol) are coproducts of rearrangement. The mechanism of rearrangement of the adamantyl and methoxybenzyl systems, in both benzene d(6) and acetone-d(6) solvents, is ambiguous, the distinction between stepwise, with tight ion-pair intermediates, and concerted, with some charge separation, being unclear. However, both afforded a methyl ether in low yield during rearrangement in methanol solvent, which suggests a stepwise, ion-pair mechanism for rearrangement in that medium. No methanolysis product could be detected from the rearrangement of the benzyl compound in methanol, which suggests concerted rearrangement. Additional evidence that it rearranges by a concerted mechanism is the fact that it affords only one pyrazole product, whereas the others afford two or more.

  DOI：

  10.1021/jo00081a028

文献信息

• Crf Receptor Antagonists and Methods
  申请人：Luo Zhiyong

  公开号：US20070293511A1

  公开（公告）日：2007-12-20

  CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this invention have the following structure: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , Y, Ar, and Het are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.

  本发明揭示了具有治疗多种疾病的用途的CRF受体拮抗剂，包括治疗在恒温动物中表现为CRF过度分泌的疾病，如中风。本发明的CRF受体拮抗剂具有以下结构：包括立体异构体、前药和药学上可接受的盐，其中R1、R2、R3、Y、Ar和Het的定义如本文所述。还揭示了含有CRF受体拮抗剂和药学上可接受的载体的组合物，以及使用它们的方法。
• Studies of thermal rearrangements of methyl 3-alkyl-3-methyl-3H-pyrazole-5-carboxylates. Concerted, stepwise, and unclassified mechanisms
  作者：Elizabeth A. Jefferson、John Warkentin

  DOI：10.1021/jo00081a028

  日期：1994.1

  Studies of the thermal rearrangements of five 3H-pyrazoles are described, in which the migrating groups were methoxymethyl, tert-butyl, 1-adamantyl, p-methoxybenzyl, and benzyl. On the basis of reaction products, rearrangement of the (methoxymethyl)pyrazole in benzene, dichloromethane, and methanol at room temperature occurs by a stepwise mechanism, involving discrete ion-pair intermediates. Observed first-order rate constants, for the rearrangement of four of the 3H-pyrazoles in benzene-d(6) and acetone-d(6) at higher temperatures, were determined The tert-butyl compound also rearranges by a stepwise mechanism in benzene d(6), acetone-d(6), and methanol-d(4) based on the fact that isobutene and tert-butyl methyl ether (in methanol) are coproducts of rearrangement. The mechanism of rearrangement of the adamantyl and methoxybenzyl systems, in both benzene d(6) and acetone-d(6) solvents, is ambiguous, the distinction between stepwise, with tight ion-pair intermediates, and concerted, with some charge separation, being unclear. However, both afforded a methyl ether in low yield during rearrangement in methanol solvent, which suggests a stepwise, ion-pair mechanism for rearrangement in that medium. No methanolysis product could be detected from the rearrangement of the benzyl compound in methanol, which suggests concerted rearrangement. Additional evidence that it rearranges by a concerted mechanism is the fact that it affords only one pyrazole product, whereas the others afford two or more.