6-phenyl-3-(phenoxy)methyl-1,2,4-triazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 6-phenyl-3-(phenoxy)methyl-1,2,4-triazine
• 英文别名: 3-(Phenoxymethyl)-6-phenyl-1,2,4-triazine
• 化学式: C₁₆H₁₃N₃O
• 分子量: 263.299
• InChiKey: AEYXMUHIDVQPRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  47.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-溴苯乙酮 、 苯氧乙酰肼 在 aluminum oxide 作用下， 反应 0.03h， 以92%的产率得到6-phenyl-3-(phenoxy)methyl-1,2,4-triazine
  参考文献：
  名称：

  MICROWAVE ASSISTED SYNTHESIS OF NOVEL 1,2,4-TRIAZINES IN “DRY MEDIA”

  摘要：

  An efficient facile and solventless synthesis of 1,2,4-triazines using microwave is described. A non conventional synthetic procedure has been developed where solid inorganic support is used as energy transfer medium under microwave irradiation (MWI) which devoids hazards of solution phase reactions. The reaction time has been brought down from hours to seconds with improved yield as compared to conventional heating.

  DOI：

  10.1081/scc-100103982

文献信息

• MICROWAVE ASSISTED SYNTHESIS OF NOVEL 1,2,4-TRIAZINES IN “DRY MEDIA”
  作者：Mazaahir Kidwai、Pooja Sapra、Kumar Ranjan Bhushan、Preeti Misra

  DOI：10.1081/scc-100103982

  日期：2001.1

  An efficient facile and solventless synthesis of 1,2,4-triazines using microwave is described. A non conventional synthetic procedure has been developed where solid inorganic support is used as energy transfer medium under microwave irradiation (MWI) which devoids hazards of solution phase reactions. The reaction time has been brought down from hours to seconds with improved yield as compared to conventional heating.