5-(6,7-dimethoxy-quinolin-4-yloxy)-1H-indole-2-carboxylic acid pentafluorophenyl ester

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-(6,7-dimethoxy-quinolin-4-yloxy)-1H-indole-2-carboxylic acid pentafluorophenyl ester
• 英文别名: (2,3,4,5,6-pentafluorophenyl) 5-(6,7-dimethoxyquinolin-4-yl)oxy-1H-indole-2-carboxylate
• 化学式: C₂₆H₁₅F₅N₂O₅
• 分子量: 530.408
• InChiKey: AGNCUIPVYSZLAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  82.7
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  5-(6,7-dimethoxy-quinolin-4-yloxy)-1H-indole-2-carboxylic acid pentafluorophenyl ester 、 环丙基甲胺 以 四氢呋喃 为溶剂， 反应 8.0h， 生成 5-(6,7-dimethoxy-quinolin-4-yloxy)-1H-indole-2-carboxylic acid cyclopropylmethyl-amide
  参考文献：
  名称：

  [EN] QUINOLINE QUINAZOLINE PYRIDINE AND PYRIMIDINE COUNDS AND THEIR USE IN THE TREATMENT OF INFLAMMATION ANGIOGENESIS AND CANCER
  [FR] COMPOSES ET METHODES D'UTILISATION DE CES DERNIERS

  摘要：

  公开号：

  WO2005073224A3
• 作为产物：
  描述：

  5-(6,7-dimethoxy-quinolin-4-yloxy)-1H-indole-2-carboxylic acid 、 五氟苯酚 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 乙酸乙酯 为溶剂， 反应 16.0h， 生成 5-(6,7-dimethoxy-quinolin-4-yloxy)-1H-indole-2-carboxylic acid pentafluorophenyl ester
  参考文献：
  名称：

  [EN] QUINOLINE QUINAZOLINE PYRIDINE AND PYRIMIDINE COUNDS AND THEIR USE IN THE TREATMENT OF INFLAMMATION ANGIOGENESIS AND CANCER
  [FR] COMPOSES ET METHODES D'UTILISATION DE CES DERNIERS

  摘要：

  公开号：

  WO2005073224A3

文献信息

• Compounds and methods of use
  申请人：Kim Tae-Seong

  公开号：US20050245547A1

  公开（公告）日：2005-11-03

  Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物对预防和治疗HGF介导的疾病等疾病有效。该发明涵盖了新颖的化合物、类似物、前药和其药物学上可接受的盐、药物组合物以及用于预防和治疗涉及癌症等疾病和其他疾病或病况的方法。该发明还涉及制备这些化合物的过程以及在这些过程中有用的中间体。
• QUINOLINE, QUINAZOLINE, PYRIDINE AND PYRIMIDINE COUNDS AND THEIR USE IN THE TREATMENT OF INFLAMMATION, ANGIOGENESIS AND CANCER
  申请人：AMGEN INC.

  公开号：EP1711495A2

  公开（公告）日：2006-10-18
• US7626030B2
  申请人：——

  公开号：US7626030B2

  公开（公告）日：2009-12-01
• [EN] COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSES ET METHODES D'UTILISATION DE CES DERNIERS
  申请人：AMGEN INC

  公开号：WO2005073224A2

  公开（公告）日：2005-08-11

  Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
• [EN] QUINOLINE QUINAZOLINE PYRIDINE AND PYRIMIDINE COUNDS AND THEIR USE IN THE TREATMENT OF INFLAMMATION ANGIOGENESIS AND CANCER<br/>[FR] COMPOSES ET METHODES D'UTILISATION DE CES DERNIERS
  申请人：AMGEN INC

  公开号：WO2005073224A3

  公开（公告）日：2005-09-29