4-benzoyl-N-(4-hydroxyphenethyl)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-benzoyl-N-(4-hydroxyphenethyl)benzamide
• 英文别名: 4-benzoyl-N-[2-(4-hydroxyphenyl)ethyl]benzamide
• 化学式: C₂₂H₁₉NO₃
• 分子量: 345.398
• InChiKey: AJRCAWXZTNNWLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对羟基苯乙胺 、 4-苯甲酰苯甲酸 在 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.5h， 生成 4-benzoyl-N-(4-hydroxyphenethyl)benzamide
  参考文献：
  名称：

  Structure−Activity Relationships and Cancer-Cell Selective Toxicity of Novel Inhibitors of Glioma-Associated Oncogene Homologue 1 (Gli1) Mediated Transcription

  摘要：

  We report novel inhibitors of Gli1-mediated transcription as potential anticancer agents. Focused chemical libraries were designed and assessed for inhibition of functional cell-based Gli1-mediated transcription and selective toxicity toward cancer cells. The SAR was revealed, and the selectivity of the lead compounds' inhibition of Gli1-mediated transcription over that of Gli2 was determined. Compound 63 (NMDA298-1), which inhibited Gli1-mediated transcription in C3H10T1/2 cells with all IC50 of 6.9 mu M, showed 3-fold selectivity for inhibiting transcription mediated by Gli1 over that by Gli2. Cell-viability assays were performed to evaluate the chemical library in a normal cell line and a panel of cancer cell lines with or without up-regulated expression of the Gli1 gene. These compounds decreased the viability of several cancer cell lines but were less active in the noncancerous BJ-hTERT cells.

  DOI：

  10.1021/jm900106f

文献信息

• Electrically conductive polymers capable of being covalently grafted on by light, method for obtaining same and uses as supports in probes for specific identification in electronic biosensors
  申请人：Universite Joseph Fourier

  公开号：US07034164B1

  公开（公告）日：2006-04-25

  The invention relates to new, inexpensive electropolymers capable of light-induced grafting, onto which specific identification probes can be easily grafted and having optimum capacity for interaction with the target analytes (DNA/DNAc, PNA/PNAc, enzyme/substrate/Antibody/Antigen). These electropolymers capable of light-induced grafting are, for example, poly(pyrrole-benzophenone). Benzophenone forms sites for light-induced grafting. The invention also covers the mono and oligomers which make up these novel electropolymers capable of light-induced grafting. Another object of the invention is the process for their manufacture, as well as electronic biosensors containing these electropolymers capable of being grafted and/or grafted by probes for the analysis of biomolecules.

  该发明涉及新型廉价的电聚合物，能够进行光诱导嫁接，特定识别探针可以轻松地嫁接到其中，并具有与目标分析物（DNA/DNAc、PNA/PNAc、酶/底物/抗体/抗原）发生相互作用的最佳能力。这些能够进行光诱导嫁接的电聚合物，例如聚（吡咯-苯酮）。苯酮形成光诱导嫁接的位点。该发明还涵盖构成这些新型能够进行光诱导嫁接的电聚合物的单体和寡聚体。该发明的另一个目的是它们的制造过程，以及包含这些能够进行嫁接和/或通过探针嫁接用于生物分子分析的电子生物传感器。
• ELECTROPOLYMERES PHOTOGREFFABLES, LEUR PROCEDE D'OBTENTION ET LEURS APPLICATIONS COMME SUPPORTS DE SONDES DE RECONNAISSANCE SPECIFIQUE DANS DES BIOCAPTEURS ELECTRONIQUES
  申请人：UNIVERSITE JOSEPH FOURIER, UJF-INDUSTRIE

  公开号：EP1203047B1

  公开（公告）日：2008-01-09
• Structure−Activity Relationships and Cancer-Cell Selective Toxicity of Novel Inhibitors of Glioma-Associated Oncogene Homologue 1 (Gli1) Mediated Transcription
  作者：Neeraj Mahindroo、Michele C. Connelly、Chandanamali Punchihewa、Hiromichi Kimura、Matthew P. Smeltzer、Song Wu、Naoaki Fujii

  DOI：10.1021/jm900106f

  日期：2009.7.23

  We report novel inhibitors of Gli1-mediated transcription as potential anticancer agents. Focused chemical libraries were designed and assessed for inhibition of functional cell-based Gli1-mediated transcription and selective toxicity toward cancer cells. The SAR was revealed, and the selectivity of the lead compounds' inhibition of Gli1-mediated transcription over that of Gli2 was determined. Compound 63 (NMDA298-1), which inhibited Gli1-mediated transcription in C3H10T1/2 cells with all IC50 of 6.9 mu M, showed 3-fold selectivity for inhibiting transcription mediated by Gli1 over that by Gli2. Cell-viability assays were performed to evaluate the chemical library in a normal cell line and a panel of cancer cell lines with or without up-regulated expression of the Gli1 gene. These compounds decreased the viability of several cancer cell lines but were less active in the noncancerous BJ-hTERT cells.