[6-methyl-3-(4-methylphenyl)-1H-indene]-1-spiro-3'-(5'-chloroindolin-2'-one)

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [6-methyl-3-(4-methylphenyl)-1H-indene]-1-spiro-3'-(5'-chloroindolin-2'-one)
• 英文别名: 5-chloro-6'-methyl-3'-(4-methylphenyl)spiro[1H-indole-3,1'-indene]-2-one
• 化学式: C₂₄H₁₈ClNO
• 分子量: 371.866
• InChiKey: AKPTZZPPOBRRHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,1-二(对甲苯)乙烯 、 5-氯靛红 在 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 以80%的产率得到[6-methyl-3-(4-methylphenyl)-1H-indene]-1-spiro-3'-(5'-chloroindolin-2'-one)
  参考文献：
  名称：

  Simple and One-Pot Protocol for Synthesis of Indene-spiro-oxindoles Involving Tandem Prins and Friedel−Crafts Reactions

  摘要：

  A simple and one-pot protocol for the synthesis of indene-spiro-oxindole derivatives via TiCl4-mediated reaction between 1,1-diarylethylenes and isatin derivatives involving construction of two carbon-carbon bonds through tandem Prins and intramolecular Friedel-Crafts (PFC) reactions has been described. A plausible mechanism for this transformation is also presented.

  DOI：

  10.1021/ol062561m

文献信息

• Simple and One-Pot Protocol for Synthesis of Indene-spiro-oxindoles Involving Tandem Prins and Friedel−Crafts Reactions
  作者：Deevi Basavaiah、Kanumuri Ramesh Reddy

  DOI：10.1021/ol062561m

  日期：2007.1.1

  A simple and one-pot protocol for the synthesis of indene-spiro-oxindole derivatives via TiCl4-mediated reaction between 1,1-diarylethylenes and isatin derivatives involving construction of two carbon-carbon bonds through tandem Prins and intramolecular Friedel-Crafts (PFC) reactions has been described. A plausible mechanism for this transformation is also presented.