6-[5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]-2,3,4,9-tetrahydro-1H-carbazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-[5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]-2,3,4,9-tetrahydro-1H-carbazole
• 化学式: C₂₂H₂₃N₃O
• 分子量: 345.444
• InChiKey: ALPCHFMDCXSHBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  49.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  环己酮 、 3-[4-[5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl]oxadiazol-3-ium-5-olate 在 盐酸 、 水 作用下， 以 乙醇 为溶剂， 反应 3.5h， 以77%的产率得到6-[5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]-2,3,4,9-tetrahydro-1H-carbazole
  参考文献：
  名称：

  One-pot synthesis of pyrazoline derivatised carbazoles as antitubercular, anticancer agents, their DNA cleavage and antioxidant activities

  摘要：

  Novel tricyclic carbazoles 4a-k were synthesized in one-pot employing sydnone derivatives 3a-k as masked hydrazines by the ring transformation in presence of conc. HCl and cyclohexanone. The title compounds were screened for anti-tubercular, anti cancer, DNA cleavage, antioxidant activity. MIC, GI50, LC50, TGI were evaluated. The title compounds have exhibited significant antitubercular, DNA cleavage and antioxidant activities and partial anticancer activity. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.07.007

文献信息

• One-pot synthesis of pyrazoline derivatised carbazoles as antitubercular, anticancer agents, their DNA cleavage and antioxidant activities
  作者：Tasneem Taj、Ravindra R. Kamble、T.M. Gireesh、Raveendra K. Hunnur、Sheetal B. Margankop

  DOI：10.1016/j.ejmech.2011.07.007

  日期：2011.9

  Novel tricyclic carbazoles 4a-k were synthesized in one-pot employing sydnone derivatives 3a-k as masked hydrazines by the ring transformation in presence of conc. HCl and cyclohexanone. The title compounds were screened for anti-tubercular, anti cancer, DNA cleavage, antioxidant activity. MIC, GI50, LC50, TGI were evaluated. The title compounds have exhibited significant antitubercular, DNA cleavage and antioxidant activities and partial anticancer activity. (C) 2011 Elsevier Masson SAS. All rights reserved.