2-(p-methoxyphenyl)-8-pentyloxyimidazo[1,2-a]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(p-methoxyphenyl)-8-pentyloxyimidazo[1,2-a]pyridine
• 英文别名: 2-(4-Methoxyphenyl)-8-pentoxyimidazo[1,2-a]pyridine
• 化学式: C₁₉H₂₂N₂O₂
• 分子量: 310.396
• InChiKey: ALXXQTXHFGXTHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  35.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-n-pentyloxy-2-aminopyridine 生成 2-(p-methoxyphenyl)-8-pentyloxyimidazo[1,2-a]pyridine
  参考文献：
  名称：

  YANAGISAWA, ISAD;SAITAMA;SHIKAMA, HISATAKA;MIYATA, KEIJI

  摘要：

  DOI：

文献信息

• Imidazopyridine derivatives, their production, and pharmaceutical compositions containing them
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0266890A1

  公开（公告）日：1988-05-11

  The present invention relates to imidazo-pyridine derivatives of formula (I) below(and pharmaceutically acceptable salts thereof) which possess H+, K+-adenosine triphosphatase inhibition activity and are useful as prophylactic and treating agents for gastric diseases; to pharmaceutical compositions containing them; and to processes for production thereof wherein: R' represents an alkenyl group having 4 to 6 carbon atoms,or an alkyl group having 1 to 10 carbon atoms which may have a cycloalkyl group substituent; R2 represents a hydroxy group, a lower alkoxycarbonyl group, a lower alkyl group which may have a hydroxy, lower alkoxy, or lower alkoxycarbonyl group substituent, a phenyl group which may have a lower alkoxy group substituent or a lower acyloxyalkyl group which may have a lower acyloxy group substituent; and, R3 represents a hydrogen atom, a lower alkyl group, a halogeno-Iower alkyl group, a lower alkoxyalkyl group, a hydroxy-lower alkyl group, a cyano-lower alkyl group, a mono-or di-lower alkylamino-lower alkyl group, an amino group, a mono-or di-lower alkylamino group, a nitroso group, a lower alkoxy-carbonyl group, a lower acylamino group, a lower alkylsulfonylamino group, a group of formula: (wherein D is NH or S, E is N or CH,and R5 and R6 are the same or different and selected from a hydrogen atom and lower alkyl, lower alkoxycarbonyl and phenyl groups); a group of formula: (wherein X is O, S or N-R7 wherein R7 is a sulfamoyl group, a lower acylamino group or a lower alkynyl group); or a group of formula: (wherein Y is O or S and R8 is a cyano-lower alkyl group or a lower alkynyl group).

  本发明涉及下式（I）所示的咪唑吡啶衍生物（及其药学上可接受的盐），其具有H+，K+-腺苷三磷酸酶抑制活性，并可用作胃病的预防和治疗剂；含有它们的药物组合物；以及生产它们的方法，其中：R'代表具有4至6个碳原子的烯基基团，或具有1至10个碳原子的烷基基团，可能具有环烷基基团取代基；R2代表羟基、较低的烷氧羰基基团、较低的烷基基团，可能具有羟基、较低的烷氧基或较低的烷氧羰基取代基，可能具有较低的烷氧基取代基或较低的酰氧基烷基基团的苯基，可能具有较低的酰氧基取代基；R3代表氢原子、较低的烷基基团、卤代较低的烷基基团、较低的烷氧基烷基基团、羟基较低的烷基基团、氰基较低的烷基基团、一或二较低的烷基氨基较低的烷基基团、氨基、一或二较低的烷基氨基基团、亚硝基基团、较低的烷氧基羰基基团、较低的酰氨基基团、较低的烷基磺酰氨基基团，下式的基团：（其中D为NH或S，E为N或CH，R5和R6相同或不同，选择自氢原子和较低的烷基、较低的烷氧羰基和苯基）；下式的基团：（其中X为O、S或N-R7，其中R7为磺酰氨基基团、较低的酰氨基基团或较低的炔基基团）；或下式的基团：（其中Y为O或S，R8为氰基较低的烷基基团或较低的炔基基团）。