(E)-N'-(3-hydroxy-2-iodo-4-methoxybenzylidene)-4-(7-methyl-1H-benzo[d]imidazol-2-yl)benzohydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: (E)-N'-(3-hydroxy-2-iodo-4-methoxybenzylidene)-4-(7-methyl-1H-benzo[d]imidazol-2-yl)benzohydrazide
• 英文别名: N-[(E)-(3-hydroxy-2-iodo-4-methoxyphenyl)methylideneamino]-4-(4-methyl-1H-benzimidazol-2-yl)benzamide
• 化学式: C₂₃H₁₉IN₄O₃
• 分子量: 526.333
• InChiKey: AMUAMNZCCWKYPM-BRJLIKDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  99.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  sodium hydroxy(4-(methoxycarbonyl)phenyl)methanesulfonate 在 hydrazine hydrate 、 溶剂黄146 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 、 正丁醇 为溶剂， 反应 25.0h， 生成 (E)-N'-(3-hydroxy-2-iodo-4-methoxybenzylidene)-4-(7-methyl-1H-benzo[d]imidazol-2-yl)benzohydrazide
  参考文献：
  名称：

  Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities

  摘要：

  4-Methylbenzimidazole 1-28 novel derivatives were synthesized and evaluated for their antiglycation and antioxidant activities. Compounds 1-7 and 11 showed excellent activities ranged 140-280 μM, better than standard drug rutin (294.46 ± 1.50 μM). Compound 1-28 were also evaluated for DPPH activities. Compounds 1-8 showed excellent activities, ranging 12-29 μM, better than standard drug n-propylgallate (IC50 = 30.30 ± 0.40 μM). For superoxide anion scavenging activity, compounds 1-7 showed better activity than standard n-propylgallate (IC50 = 106.34 ± 1.6 μM), ranged 82-104 μM. These compounds were found to be nontoxic to THP-1 cells.

  DOI：

  10.1016/j.ejmech.2014.07.078