10-hydroxyoctadecanoic acid 3-hydroxy-2-hydroxymethyl-2-(10-hydroxyoctadecanoylamino)propyl ester

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 10-hydroxyoctadecanoic acid 3-hydroxy-2-hydroxymethyl-2-(10-hydroxyoctadecanoylamino)propyl ester
• 英文别名: [3-Hydroxy-2-(hydroxymethyl)-2-(10-hydroxyoctadecanoylamino)propyl] 10-hydroxyoctadecanoate；[3-hydroxy-2-(hydroxymethyl)-2-(10-hydroxyoctadecanoylamino)propyl] 10-hydroxyoctadecanoate
• 化学式: C₄₀H₇₉NO₇
• 分子量: 686.07
• InChiKey: ARLGGLQDBHKNLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11
• 重原子数：
  48
• 可旋转键数：
  38
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  136
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  10-羟基硬脂酸 、 三羟甲基氨基甲烷 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.5h， 以39%的产率得到10-hydroxyoctadecanoic acid 3-hydroxy-2-hydroxymethyl-2-(10-hydroxyoctadecanoylamino)propyl ester
  参考文献：
  名称：

  EP2927211

  摘要：

  公开号：

文献信息

• NOVEL PSEUDOCERAMIDE COMPOUND AND PRODUCTION METHOD FOR SAME
  申请人：Amorepacific Corporation

  公开号：EP2927211A1

  公开（公告）日：2015-10-07

  The present invention provides: a novel pseudoceramide compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof or a solvate thereof. The present invention has a skin protecting effect in that the invention has a superior effect in skin moisturisation and is outstandingly stable and soluble, and thus the invention can protect the skin from external irritation without side effects, and can be used as an active substance in damaged skin recovery and prevention. Consequently, the invention can be used as a skin-moisturising dermatological external composition, cosmetic composition or pharmaceutical composition.

  本发明提供了：一种新型伪酰脲化合物、其异构体、其药学上可接受的盐、其原药、其水合物或其溶液。本发明具有保护皮肤的作用，即本发明具有优越的皮肤保湿效果，且稳定性和溶解性突出，因此本发明可以保护皮肤免受外界刺激，且无副作用，可作为活性物质用于受损皮肤的恢复和预防。因此，本发明可用作皮肤保湿皮肤外用组合物、化妆品组合物或药物组合物。
• [EN] NOVEL PSEUDOCERAMIDE COMPOUND AND PRODUCTION METHOD FOR SAME<br/>[FR] COMPOSÉ INÉDIT DE TYPE PSEUDOCÉRAMIDE ET SON PROCÉDÉ DE PRODUCTION
  申请人：AMOREPACIFIC CORP

  公开号：WO2014084676A1

  公开（公告）日：2014-06-05

  본 발명은 신규한 유사 세라마이드 화합물, 이의 이성질체, 이의 약학적으로 허용 가능한 염, 이의 프로드럭, 이의 수화물 또는 이의 용매화물을 제공한다. 본 발명에 따르면, 안정성 및 용해도가 우수하고 피부 보습에 효과가 뛰어나 피부 보호 효과를 가지므로, 부작용 없이 외부자극으로부터 피부를 보호하고, 손상된 피부회복 및 예방용 유효물질로 사용 가능하다. 따라서, 피부 보습용 피부 외용제 조성물, 화장료 조성물 또는 약학 조성물로 사용될 수 있다.