1-(4-bromophenyl)-3-(pyridin-4-yl)prop-2-en-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-bromophenyl)-3-(pyridin-4-yl)prop-2-en-1-one
• 英文别名: 1-(4-Bromophenyl)-3-pyridin-4-ylprop-2-en-1-one
• 化学式: C₁₄H₁₀BrNO
• 分子量: 288.143
• InChiKey: ATAYCKUNMDQYGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-吡啶甲醛 、 4-溴苯乙酮 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以84.7%的产率得到1-(4-bromophenyl)-3-(pyridin-4-yl)prop-2-en-1-one
  参考文献：
  名称：

  Synthesis and antifungal activity of chalcone derivatives

  摘要：

  In the present study, using chalcone as a lead compound, a series of its derivatives (compounds 1-30) were designed and synthesised. Their activity of anti-pathogenic fungi of plants has been evaluated. It is found that these compounds have good antifungal activity against Sclerotinia sclerotiorum, Helminthosprium maydis, Botrytis cinerea, Rhizoctonia solani and Gibberella zeae. Among them, the inhibition of growth for compound 30 against S. sclerotiorum showed 89.9%, with the median effective concentrations (EC50) of 15.4gmL(-1). The inhibition of growth for compounds 28, 29 and 30 at a concentration of 100gmL(-1) against H. maydis is 90.3%, 90.7% and 91.1%, with EC50 of 15.1, 18.3 and 18.1gmL(-1), respectively.

  DOI：

  10.1080/14786419.2015.1007973

文献信息

• Synthesis and antifungal activity of chalcone derivatives
  作者：Yuanyuan Zheng、Xuesong Wang、Sumei Gao、Min Ma、Guiming Ren、Huabing Liu、Xiaohong Chen

  DOI：10.1080/14786419.2015.1007973

  日期：2015.10.2

  In the present study, using chalcone as a lead compound, a series of its derivatives (compounds 1-30) were designed and synthesised. Their activity of anti-pathogenic fungi of plants has been evaluated. It is found that these compounds have good antifungal activity against Sclerotinia sclerotiorum, Helminthosprium maydis, Botrytis cinerea, Rhizoctonia solani and Gibberella zeae. Among them, the inhibition of growth for compound 30 against S. sclerotiorum showed 89.9%, with the median effective concentrations (EC50) of 15.4gmL(-1). The inhibition of growth for compounds 28, 29 and 30 at a concentration of 100gmL(-1) against H. maydis is 90.3%, 90.7% and 91.1%, with EC50 of 15.1, 18.3 and 18.1gmL(-1), respectively.