3-phenylpyrazole-5-diazonium

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-phenylpyrazole-5-diazonium
• 英文别名: 5-phenyl-1H-pyrazole-3-diazonium
• 化学式: C₉H₇N₄
• 分子量: 171.181
• InChiKey: AYKRBEYFHXGSTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-phenylpyrazole-5-diazonium 以 吡啶 、 乙醇 为溶剂， 反应 35.5h， 生成 4-amino-3-[(7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl)carbonyl]-7-phenylpyrazolo[5,1-c]-1,2,4-triazine
  参考文献：
  名称：

  Convergent synthesis and antibacterial activity of pyrazole and pyrazoline derivatives of diazepam

  摘要：

  Polysubstituted pyrazoles (5)(a-l), pyrazolines (7)(a-c), (8)(a-c) and pyrazolotriazine (10) derivatives of diazepam were synthesized. The structures of hitherto unknown compounds were established by analytical and spectral methods. Some of these compounds were screened to test their antibacterial activity against gram-positive (B. subtilis) and gram-negative (P. aeruginosa). All compounds showed potent activity against these bacteria. (C) 2003 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/s0928-0987(03)00162-3

文献信息

• Synthesis of some new pyridones, fused pyrimidines, and fused 1,2,4-triazines
  作者：Mahmoud A. Mohamed

  DOI：10.1002/jhet.351

  日期：——

  Cyclocondensation of hydrazides, 3-aminopyrazoles, 3-amino-1,2,4-triazole, 2-aminobenzoimidazole, pyrazole-3-diazonium salts, 1,2,4-triazol-3-diazonium salt, or benzoimidazole-2-diazonium salt with sodium salt of 3-hydroxy-1-(2-naphthyl)prop-2-en-1-one gave 2-pyridones, pyrazolo[1,5-a]pyrimidines, triazolo[1,5-a]pyrimidine, benzo[4,5]imidazo[1,2-a]pyrimidine, (pyrazolo[5,1-c][1,2,4]triazin-3-yl)-methanone

  酰肼，3-氨基吡唑， 3-氨基-1,2,4-三唑，2-氨基苯并咪唑，吡唑-3-重氮盐，1,2,4-三唑-3-重氮盐或苯并咪唑-2-重氮盐与3-羟基-1-（2-萘基）丙-2-的钠盐烯-1-酮产生2-吡啶酮，吡唑并[1,5- a ]嘧啶，三唑并[1,5- a ]嘧啶，苯并[4,5]咪唑并[1,2- a ]嘧啶，（吡唑并[5,1- c ] [1,2,4]三嗪-3-基）-甲酮，[1,2,4] triazolo [5,1- c ] [1,2,4] triazin-3-yl-methanone或苯并[4,5]咪唑[2,1- c ] [1,2，分别测试4] triazin-3-yl-methanone衍生物的抗肿瘤和抗癌活性。J.杂环化​​学。（2010）。
• Dawood, Kamal M.; Farag, Ahmad M.; Abdel-Aziz, Hatem A., Journal of Chemical Research, 2005, # 6, p. 378 - 381
  作者：Dawood, Kamal M.、Farag, Ahmad M.、Abdel-Aziz, Hatem A.

  DOI：——

  日期：——