三羟甲基氨基甲烷马来酸酯 | 72200-76-1

• 物质功能分类: 化学试剂 - 有机试剂 - 酯类
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 三羟甲基氨基甲烷马来酸酯
• 中文别名: Tris马来酸盐
• 英文名称: TRIS maleate salt
• 英文别名: 2-amino-2-(hydroxymethyl)propane-1,3-diol;(Z)-but-2-enedioic acid
• CAS: 72200-76-1
• 化学式: C4H11NO3.C4H4O4
• 分子量: 237.21
• InChiKey: HTMWOUBCEZXSHN-BTJKTKAUSA-N

物化性质

• 熔点：
  103-105 °C
• 溶解度：
  H2O: 0.5 M ， 20 °C, 澄清

计算性质

• 辛醇/水分配系数(LogP)：
  -2.63
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  161
• 氢给体数：
  6
• 氢受体数：
  8

安全信息

• 安全说明：
  S24/25
• WGK Germany：
  3
• 海关编码：
  29221929

文献信息

• Compositions and methods for hydroxylating epothilones
  申请人：——

  公开号：US20030180760A1

  公开（公告）日：2003-09-25

  Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.

  本文提供了编码依波利酮B羟化酶及其突变体和变异体的孤立核酸序列和多肽，以及位于依波利酮B羟化酶基因下游的一种ferredoxin。还提供了包含这些向量的质粒和细胞。此外，还提供了生产重组微生物的方法，使用这些重组微生物生产含羟基的依波利酮和依波利酮B羟化酶突变体产生的依波利酮类似物的方法。
• Stable composition for the determination of peroxidatively active substances
  申请人：MILES INC.

  公开号：EP0230229A2

  公开（公告）日：1987-07-29

  A stable test device for the determination of a peroxidatively active substance comprising a carrier containing 1,4-diisopropylbenzene dihydroperoxide and a benzidine indicator in a molar ratio of from 0.9 to 3.0. The composition can be incorporated with a carrier matrix with a ferric chelate to provide ascorbate resistance, important in a urine test for occult blood. The test device is stable under storage and heat stress and can be used to prepare a multitest strip containing a glucose test based on a peroxidase/potassium iodide indicator system.

  一种用于测定过氧化活性物质的稳定检测装置，由含有 1,4-二异丙苯二过氧化氢和联苯胺指示剂的载体组成，摩尔比为 0.9 至 3.0。 该组合物可与含有铁螯合物的载体基质结合，以提供抗坏血酸抗性，这在尿液隐血检测中非常重要。 该检测装置在储存和热应力条件下稳定，可用于制备含有基于过氧化物酶/碘化钾指示剂系统的葡萄糖检测试纸的多重检测条。
• Strain mass-producing Epsilon-poly-L-lysine, a method for using its strain and a method for producing Epsilon-poly-L-lysine
  申请人：Chisso Corporation

  公开号：EP0256423A2

  公开（公告）日：1988-02-24

  The present invention provides variant strains mass-producing εPL which are obtained by variant treatment of a strain producing εPL. For using the variant strains, the strains are cultured in a cultivated medium, εPL is mass-produced and stored in the culture solution, and the stored εPL is collected from the solution. For producing εPL, a strain which produces εPL is variant-treated, the obtained variant strain is cultivated in a culture medium to which L-lysine or L-lysine and one or more sugars are added, εPL is mass-produced and stored in the culture solution, and the stored εPL is collected from the solution. The variant strains producing εPL in large quantities are preferably the strains which have tolerance to an analogue of L-lysine of Streptomyces albulus subsp. lysinopolymerus No.346-D strain and plasmid-amplifiable variant strains of the same bacteria.

  本发明提供了大量产生εPL 的变异菌株，这些菌株是通过对产生εPL 的菌株进行变异处理而获得的。使用变异菌株时，在培养基中培养菌株，大量生产εPL 并将其储存在培养液中，然后从培养液中收集储存的εPL。为了产生εPL，对产生εPL的菌株进行变异处理，在加入 L-赖氨酸或 L-赖氨酸和一种或多种糖的培养基中培养获得的变异菌株，大量生产εPL并将其储存在培养液中，然后从培养液中收集储存的εPL。 大量生产 εPL 的变异菌株最好是对白链霉菌亚种赖氨酸类似物有耐受性的菌株，以及同一细菌中可进行质粒扩增的变异菌株。
• A process for producing carboxylic acid esters
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0269453A2

  公开（公告）日：1988-06-01

  A process for producing a carboxylic acid ester which comprises reacting a hydroxy compound with a carboxylic anhydride in the presence of carboxyl esterase as a catalyst in an organic solvent.

  一种生产羧酸酯的工艺，包括在有羧酸酯酶作为催化剂的情况下，在有机溶剂中使羟基化合物与羧酸酐反应。
• Use of Interleukin-4 for increasing numbers of neutrophils and for treating myeloid or monocytoid leukaemia.
  申请人：SCHERING CORPORATION

  公开号：EP0410750A2

  公开（公告）日：1991-01-30

  Methods for increasing the numbers of neutrophils and for inducing the maturation of myeloid cells in mammals by administering IL-4 are disclosed. Also disclosed are processes for purifying active recombinant human interleukin-4 from certain E. coli fermentation broths or from certain CHO-cell cell culture mediums.

  公开了通过施用 IL-4 增加哺乳动物中性粒细胞数量和诱导髓细胞成熟的方法。还公开了从某些大肠杆菌发酵液或某些 CHO 细胞培养基中纯化活性重组人白细胞介素-4 的工艺。