D,L-allysinamide ethylene acetal

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: D,L-allysinamide ethylene acetal
• 英文别名: 2-amino-5-(1,3-dioxolane-2-yl)-pentanoic acid amide；2-Amino-5-(1,3-dioxolan-2-yl)pentanamide
• 化学式: C₈H₁₆N₂O₃
• 分子量: 188.227
• InChiKey: BCFZIUVRIDQCHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  87.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  D,L-allysinamide ethylene acetal 生成 allysine acetal 、 (S)-2-氨基-5-(1,3-二氧戊环-2-基)戊酸
  参考文献：
  名称：

  Method for producing L-Allysine acetal

  摘要：

  公开号：

  EP0972845B1

文献信息

• Polypeptides having alpha-H-alpha-amino acid amide racemase activity and nucleic acids encoding the same
  申请人：——

  公开号：US20040248274A1

  公开（公告）日：2004-12-09

  The invention relates to isolated polypeptides having &agr;-H-&agr;-amino acid amide racemase activity and nucleic acids encoding the same. The invention also relates to vectors and host cells comprising the nucleic acids according to the invention. The invention also relates to methods of producing and using the polypeptides according to the invention. The invention also relates to a method for isolating polypeptides having &agr;-H-&agr;-amino acid amide racemase activity, for isolating nucleic acids encoding the same and for isolating microorganisms comprising polypeptides having &agr;-H-&agr;-amino acid amide racemase activity. The invention also relates to new microorganisms comprising polypeptides having &agr;-H-&agr;-amino acid amide racemase activity.

  该发明涉及具有α-H-α-氨基酸酰胺旋转酶活性的分离多肽和编码其的核酸。该发明还涉及包含该发明核酸的载体和宿主细胞。该发明还涉及根据该发明产生和使用多肽的方法。该发明还涉及一种分离具有α-H-α-氨基酸酰胺旋转酶活性的多肽，分离编码其的核酸以及分离包含具有α-H-α-氨基酸酰胺旋转酶活性的多肽的微生物的方法。该发明还涉及含有具有α-H-α-氨基酸酰胺旋转酶活性的多肽的新微生物。
• Process for preparing optically active 2-amino-Omega-oxoalkanoic acid derivatives
  申请人：DSM N.V.

  公开号：EP0905257A1

  公开（公告）日：1999-03-31

  Process for preparing an (S)-2-amino-ω-oxoalkanoic acid derivative in which the corresponding aldehyde is converted into the corresponding acetal-protected aldehyde, the acetal-protected aldehyde is converted into the corresponding aminonitrile, the aminonitrile is converted into the corresponding amino acid amide, the amino acid amide is subjected to an enzymatic, enantioselective hydrolysis in which the R enantiomer of the amino acid amide remains and the S enantiomer is converted into the S amino acid, and the S amino acid is isolated. Preferably, the reaction mixture obtained after the conversion of the aminonitrile into the amino acid amide is treated with a benzaldehyde, upon which the Schiff base of the amino acid amide is formed, the Schiff base is separated and is converted into the free amino acid amide.

  制备(S)-2-氨基-ω-氧代烷酸衍生物的工艺，其中相应的醛转化为相应的受乙缩醛保护的醛，受乙缩醛保护的醛转化为相应的氨基腈、将氨基腈转化为相应的氨基酸酰胺，将氨基酸酰胺进行酶法对映选择性水解，其中氨基酸酰胺的 R 对映体保留，S 对映体转化为 S 氨基酸，然后分离出 S 氨基酸。最好将氨基腈转化为氨基酸酰胺后得到的反应混合物用苯甲醛处理，在苯甲醛上形成氨基酸酰胺的希夫碱，分离希夫碱并将其转化为游离氨基酸酰胺。
• POLYPEPTIDES HAVING a- H-a-AMINO ACID AMIDE RACEMASE ACTIVITY AND NUCLEIC ACIDS ENCODING THE SAME
  申请人：DSM IP Assets B.V.

  公开号：EP1513946A1

  公开（公告）日：2005-03-16
• POLYPEPTIDES HAVING ALPHA-H-ALPHA AMINO ACID AMIDE RACEMASE ACTIVITY AND NUCLEIC ACIDS ENCODING THE SAME
  申请人：DSM IP Assets B.V.

  公开号：EP1513946B1

  公开（公告）日：2007-05-16
• US6133002A
  申请人：——

  公开号：US6133002A

  公开（公告）日：2000-10-17