tert-butyl 39-hydroxy-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl 39-hydroxy-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontanoate
• 英文别名: Tert-butyl 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(3-hydroxypropoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetate；tert-butyl 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(3-hydroxypropoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetate
• 化学式: C₃₁H₆₂O₁₅
• 分子量: 674.824
• InChiKey: BFBQDAQMOYEVQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  46
• 可旋转键数：
  40
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  157
• 氢给体数：
  1
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  tert-butyl 39-hydroxy-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontanoate 在 三苯基膦 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 20.25h， 生成 39-(3,4-dibromo-2,5-dioxopyrrolyl)-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontanoic acid
  参考文献：
  名称：

  Antibody-Drug Conjugates, Compositions and Methods of Use

  摘要：

  抗体-细胞毒素抗体药物偶联物及相关化合物，如连接剂-细胞毒素偶联物和用于制备它们的连接剂，管芽菌素类似物和其合成中间体；组合物；以及方法，包括治疗癌症的方法。

  公开号：

  US20140363454A1

文献信息

• Antibody-Drug Conjugates and Related Compounds, Compositions, and Methods
  申请人：Igenica, Inc.

  公开号：US20130224228A1

  公开（公告）日：2013-08-29

  Antibody-cytotoxin antibody-drug conjugates and related compounds, such as linker-cytotoxin conjugates and the linkers used to make them, tubulysin analogs, and intermediates in their synthesis; compositions; and methods, including methods of treating cancers.

  抗体-细胞毒素抗体-药物偶联物及相关化合物，例如连接剂-细胞毒素偶联物和用于制造它们的连接剂，管芽菌素类似物和它们合成中的中间体；组成物；和方法，包括治疗癌症的方法。
• ANTIBODY-DRUG CONJUGATES, COMPOSITIONS AND METHODS OF USE
  申请人：JACKSON David Y.

  公开号：US20180147294A1

  公开（公告）日：2018-05-31

  Antibody-cytotoxin antibody-drug conjugates and related compounds, such as linker-cytotoxin conjugates and the linkers used to make them, tubulysin analogs, and intermediates in their synthesis; compositions; and methods, including methods of treating cancers.
• ANTIBODY-DRUG CONJUGATES AND RELATED COMPOUNDS, COMPOSITIONS AND METHODS
  申请人：Magenta Therapeutics, Inc.

  公开号：US20200392108A1

  公开（公告）日：2020-12-17

  Antibody-cytotoxin antibody-drug conjugates and related compounds, such as linker-cytotoxin conjugates and the linkers used to make them, tubulysin analogs, and intermediates in their synthesis; compositions; and methods, including methods of treating cancers.
• Antibody-Drug Conjugates, Compositions and Methods of Use
  申请人：Igenica Biotherapeutics, Inc.

  公开号：US20140363454A1

  公开（公告）日：2014-12-11

  Antibody-cytotoxin antibody-drug conjugates and related compounds, such as linker-cytotoxin conjugates and the linkers used to make them, tubulysin analogs, and intermediates in their synthesis; compositions; and methods, including methods of treating cancers.

  抗体-细胞毒素抗体药物偶联物及相关化合物，如连接剂-细胞毒素偶联物和用于制备它们的连接剂，管芽菌素类似物和其合成中间体；组合物；以及方法，包括治疗癌症的方法。