(R)-4-(diethoxyphosphoryl)-3-oxobutanoic acid methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: (R)-4-(diethoxyphosphoryl)-3-oxobutanoic acid methyl ester
• 英文别名: methyl (3R)-4-diethoxyphosphoryl-3-hydroxybutanoate
• 化学式: C₉H₁₉O₆P
• 分子量: 254.22
• InChiKey: BGDKXTIMXIOGLJ-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-溴-3-氧代-丁酸甲酯 在 baker's yeast 作用下， 以 水 为溶剂， 反应 72.0h， 生成 (R)-4-(diethoxyphosphoryl)-3-oxobutanoic acid methyl ester
  参考文献：
  名称：

  面包酵母对 4-(二烷氧基磷酰基)-3-氧代丁酸二烷基酯的对映选择性还原

  摘要：

  4-(二烷氧基磷酰基)-3-氧代丁酸二烷基酯 (1) 在酵母介导的生物还原作用下以中等至良好的产率和 ee 值提供手性二烷基 4-(二烷氧基磷酰基)-3-羟基丁酸酯 (2)。据报道，4-（二烷氧基磷酰基）-3-氧代丁酸二烷基酯 (1) 的制备得到了显着改进，这是该生物还原转化的关键底物。© 2002 Wiley Periodicals, Inc. 杂原子化学 13:153–156, 2002; 在线发表于 Wiley Interscience (www.interscience.wiley.com)。DOI 10.1002/hc.10011

  DOI：

  10.1002/hc.10011

文献信息

• Phosphonate analogs for treating metabolic diseases
  申请人：Chen M. James

  公开号：US20050227947A1

  公开（公告）日：2005-10-13

  The invention is related to phosphorus substituted compounds with activity for treating metabolic diseases and/or disorders, e.g., diabetes and hypercholesterolemia, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及具有治疗代谢性疾病和/或紊乱（如糖尿病和高胆固醇血症）活性的磷取代化合物、含有此类化合物的组合物、包括施用此类化合物的治疗方法，以及用于制备此类化合物的工艺和中间体。
• PHOSPHONATE ANALOGS FOR TREATING METABOLIC DISEASES
  申请人：Chen James M.

  公开号：US20090131372A1

  公开（公告）日：2009-05-21

  The invention is related to phosphorus substituted compounds with activity for treating metabolic diseases and/or disorders, e.g., diabetes and hypercholesterolemia, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
• US7407965B2
  申请人：——

  公开号：US7407965B2

  公开（公告）日：2008-08-05
• [EN] PHOSPHONATE ANALOGS FOR TREATING METABOLIC DISEASES<br/>[FR] ANALOGUES DE PHOSPHONATES CONVENANT AU TRAITEMENT D'AFFECTIONS DU METABOLISME
  申请人：GILEAD SCIENCES INC

  公开号：WO2004096237A2

  公开（公告）日：2004-11-11

  The invention is related to phosphorus substituted compounds with activity for treating metabolic diseases and/or disorders, e.g., diabetes and hypercholesterolemia, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
• Enantioselective reduction of dialkyl 4-(dialkoxyphosphoryl)-3-oxobutanoates by baker's yeast
  作者：Chengye Yuan、Ke Wang、Jinfeng Li、Zuyi Li

  DOI：10.1002/hc.10011

  日期：——

  Dialkyl 4-(dialkoxyphosphoryl)-3-oxobutanoates (1), upon yeast-mediated bioreduction, afforded chiral dialkyl 4-(dialkoxyphosphoryl)-3-hydroxybutanoates (2) in moderate to good yields and ee values. Significant improvement was reported for the preparation of dialkyl 4-(dialkoxyphosphoryl)-3-oxobutanoates (1), the key substrates of this bioreductive conversion. © 2002 Wiley Periodicals, Inc. Heteroatom

  4-(二烷氧基磷酰基)-3-氧代丁酸二烷基酯 (1) 在酵母介导的生物还原作用下以中等至良好的产率和 ee 值提供手性二烷基 4-(二烷氧基磷酰基)-3-羟基丁酸酯 (2)。据报道，4-（二烷氧基磷酰基）-3-氧代丁酸二烷基酯 (1) 的制备得到了显着改进，这是该生物还原转化的关键底物。© 2002 Wiley Periodicals, Inc. 杂原子化学 13:153–156, 2002; 在线发表于 Wiley Interscience (www.interscience.wiley.com)。DOI 10.1002/hc.10011