申请人:Nippon Gohsei Kagaku Kogyo Kabushiki Kaisha
公开号:US05101070A1
公开(公告)日:1992-03-31
A process for preparing valproic acid which comprises: (I) producing a 2,2-dipropyl acetoacetic acid ester from an acetoacetic acid ester, (II) deacetylating the 2,2-dipropyl acetoacetic acid ester with an alcohol to give a valproic acid ester, and (III) hydrolyzing the valproic acid ester. In the process of the present invention, valproic acid can be prepared in a high yield as not less than 85% by mole and by-products such as .alpha.-propyl-.beta.-ethyl acrylic acid and its esters which cannot be easily separated from valproic acid, are not entirely produced.
一种制备丙戊酸的方法,包括:(I)从乙酰乙酸酯制备2,2-二丙基乙酰乙酸酯,(II)用醇脱乙酰基使2,2-二丙基乙酰乙酸酯成为丙戊酸酯,(III)水解丙戊酸酯。在本发明的方法中,丙戊酸可以以不低于85%的摩尔收率高效制备,而丙烷基-β-乙烯基丙酸及其酯等副产物不会完全产生且难以与丙戊酸分离。