6-Chloro-5-methyl-2,3-dihydro-indole-1-carboxylic acid [6-(2-propyl-pyridin-3-yloxy)-pyridin-3-yl]-amide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-Chloro-5-methyl-2,3-dihydro-indole-1-carboxylic acid [6-(2-propyl-pyridin-3-yloxy)-pyridin-3-yl]-amide
• 英文别名: 6-chloro-5-methyl-N-[6-(2-propylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide
• 化学式: C₂₃H₂₃ClN₄O₂
• 分子量: 422.914
• InChiKey: BINKAPHEZWXBGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-丙基吡啶-3-醇 在 盐酸 、 sodium hydride 、 三乙胺 、 tin(ll) chloride 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 21.0h， 生成 6-Chloro-5-methyl-2,3-dihydro-indole-1-carboxylic acid [6-(2-propyl-pyridin-3-yloxy)-pyridin-3-yl]-amide
  参考文献：
  名称：

  1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/Anxiolytic agents

  摘要：

  Bisaryl ethers have been identified with excellent 5-HT2C affinity and selectivity over both 5-HT2A and 5-HT2B receptors. Compounds such as 11, 27 and 38 have potent oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function and their potential as novel non-sedating anxiolytic and antidepressants is under investigation. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00364-4

文献信息

• 1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/Anxiolytic agents
  作者：Steven M. Bromidge、Steven Dabbs、Susannah Davies、D.Malcolm Duckworth、Ian T. Forbes、Graham E. Jones、Jerome Jones、Frank D. King、Damian V. Saunders、Thomas P. Blackburn、Vicky Holland、Guy A. Kennett、Sean Lightowler、Derek N. Middlemiss、Graham J. Riley、Brenda Trail、Martyn D. Wood

  DOI：10.1016/s0960-894x(00)00364-4

  日期：2000.8

  Bisaryl ethers have been identified with excellent 5-HT2C affinity and selectivity over both 5-HT2A and 5-HT2B receptors. Compounds such as 11, 27 and 38 have potent oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function and their potential as novel non-sedating anxiolytic and antidepressants is under investigation. (C) 2000 Elsevier Science Ltd. All rights reserved.