N-<4-(4-Methoxyphenoxy)phenyl>morpholine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-<4-(4-Methoxyphenoxy)phenyl>morpholine
• 英文别名: 4-(4-(4-methoxyphenoxy)phenyl)morpholine；4-[4-(4-Methoxyphenoxy)phenyl]morpholine
• 化学式: C₁₇H₁₉NO₃
• 分子量: 285.343
• InChiKey: BJLSCKMUEDNJSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  30.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  吗啉 、 1-氯-4-(4-甲氧基苯氧基)苯 在 silver tetrafluoroborate 、 chloro(η4-1,5-cyclooctadiene)(1,3-diisopropyl-1H-imidazol-2-ylidene)rhodium(I) 、 caesium carbonate 作用下， 以 乙二醇二甲醚 为溶剂， 反应 12.0h， 以57%的产率得到N-<4-(4-Methoxyphenoxy)phenyl>morpholine
  参考文献：
  名称：

  Rhodium(NHC)-Catalyzed O-Arylation of Aryl Bromides

  摘要：

  The first example of the rhodium-catalyzed O-arylation of aryl bromides is reported. While the right combination of rhodium species and N-heterocyclic carbene (NHC) offered an effective catalytic system enabling the arylation to proceed, the choice of NHC was determined to be most important. The developed O-arylation protocol has a wide range of substrate scope, high functional group tolerance, and flexibility allowing a complementary route to either N- or O-arylation depending on the choice of NHC.

  DOI：

  10.1021/ol200603c

文献信息

• OXALIC ACID MONOAMIDE LIGAND, AND USES THEREOF IN COUPLING REACTION OF COPPER-CATALYZED ARYL HALOGEN SUBSTITUTE
  申请人：Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

  公开号：EP3326715A1

  公开（公告）日：2018-05-30

  The present invention provides oxalic amide ligands and uses thereof in copper-catalyzed coupling reaction of aryl halides. Specifically, the present invention provides a use of a compound represented by formula I, wherein definitions of each group are described in the specification. The compound represented by formula I can be used as a ligand in copper-catalyzed coupling reaction of aryl halides for the formation of C-N, C-O and C-S bonds.

  本发明提供了草酸酰胺配体及其在铜催化的芳基卤化物偶联反应中的用途。具体而言，本发明提供了一种由式 I 代表的化合物的用途，其中各基团的定义在说明书中有所描述。式 I 所代表的化合物可用作铜催化的芳基卤化物偶联反应中的配体，用于形成 C-N、C-O 和 C-S 键。
• [EN] OXALIC ACID MONOAMIDE LIGAND, AND USES THEREOF IN COUPLING REACTION OF COPPER-CATALYZED ARYL HALOGEN SUBSTITUTE<br/>[FR] LIGAND DE MONOAMIDE D'ACIDE OXALIQUE, ET SES USAGES DANS UNE RÉACTION DE COUPLAGE DE SUBSTITUT HALOGÉNÉ D'ARYLE CATALYSÉ AU CUIVRE<br/>[ZH] 草酸酰胺类配体及其在铜催化芳基卤代物偶联反应中的用途
  申请人：SHANGHAI INST ORGANIC CHEMISTRY CAS

  公开号：WO2017012379A1

  公开（公告）日：2017-01-26

  本发明提供了草酸酰胺类配体及其在铜催化芳基卤代物偶联反应中的用途，具体地，本发明提供了一种如下式I所示的化合物的用途；其中，各基团的定义如说明书中所述。所述的式I化合物可以用作为铜催化芳基卤代物偶联反应中的配体，用于催化形成C-N、C-O、C-S键等芳基卤代物的偶联反应。
• Studies on Selective Nucleophilic Substitution Reactions of [(Cyclopentadienyl)(1,3- and 1,4-dichlorobenzene)Fe]+PF6- Complexes: Applications to the Synthesis of Polymer Monomers
  作者：Anthony J. Pearson、Ann M. Gelormini

  DOI：10.1021/jo00095a036

  日期：1994.8

  Selective displacement of chloride from cyclopentadienyl(1,4-dichlorobenzene)iron(1+) by a series of aryl oxide and amine nucleophiles is described. The methodology, coupled with decomplexation of the product organometallics, allows access to a series of para-disubstituted benzene derivatives that are of potential value in the construction of unusual polymers. Four such compounds, derived from sequential addition of 4-hydroxybenzoic ester and hydroquinone or resorcinol monophenoxide to the 1,4- and 1,3-dichlorobenzene-FeCp complexes, were subjected to polyesterification reactions. Previously unreported isoregic poly(ether-esters) were-prepared and characterized.
• Rhodium(NHC)-Catalyzed <i>O</i>-Arylation of Aryl Bromides
  作者：Hyun Jin Kim、Min Kim、Sukbok Chang

  DOI：10.1021/ol200603c

  日期：2011.5.6

  The first example of the rhodium-catalyzed O-arylation of aryl bromides is reported. While the right combination of rhodium species and N-heterocyclic carbene (NHC) offered an effective catalytic system enabling the arylation to proceed, the choice of NHC was determined to be most important. The developed O-arylation protocol has a wide range of substrate scope, high functional group tolerance, and flexibility allowing a complementary route to either N- or O-arylation depending on the choice of NHC.