11-(3-bromophenyl)-9,9-dimethyl-9,10-dihydroisochromeno[4,3-b]indole-5,7(8H,11H)-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 11-(3-bromophenyl)-9,9-dimethyl-9,10-dihydroisochromeno[4,3-b]indole-5,7(8H,11H)-dione
• 英文别名: 11-(3-Bromophenyl)-9,9-dimethyl-8,10-dihydroisochromeno[4,3-b]indole-5,7-dione；11-(3-bromophenyl)-9,9-dimethyl-8,10-dihydroisochromeno[4,3-b]indole-5,7-dione
• 化学式: C₂₃H₁₈BrNO₃
• 分子量: 436.305
• InChiKey: BPQNENCTOXJQFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  28
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  48.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  水合茚三酮 、 3-(3-Brom-anilino)-5,5-dimethyl-cyclohex-2-en-1-on 在 β-环糊精 作用下， 以 乙醇 、 水 为溶剂， 以81%的产率得到11-(3-bromophenyl)-9,9-dimethyl-9,10-dihydroisochromeno[4,3-b]indole-5,7(8H,11H)-dione
  参考文献：
  名称：

  寡糖辅助方法：在β-环糊精存在的情况下有效且简便地获得异色烯 [4,3-b] 吲哚衍生物

  摘要：

  在水性介质中使用 β 环糊精开发了一种完全环保且直接的生物重要异色烯 [4,3-b] 吲哚衍生物的方案。这个记录在案的策略包括消除危险的催化剂和挥发性有机溶剂。此外，该方案突出了环境友好的反应条件、反应时间短、操作简单、易于后处理和纯化程序以及产品的良好收率。

  DOI：

  10.1007/s10562-018-2592-0

文献信息

• Domino bicyclization of 2,2-dihydroxyindene-1,3-dione with cyclic enaminones leading to isochromeno[4,3-b]indoles
  作者：Fu-Jie Zhao、Mu-Yan Sun、Yi-Jing Dang、Xiao-Yan Meng、Bo Jiang、Wen-Juan Hao、Shu-Jiang Tu

  DOI：10.1016/j.tet.2014.11.005

  日期：2014.12

  New and practical acid-promoted domino bicyclization between 2,2-dihydroxyindene-1,3-dione and cyclic enaminones has been established for the formation of tetracyclic isochromeno[4,3-b]indoles under microwave heating. The present method simultaneously installs C-N, C-O, and C-C bonds, allowing direct assemble of functionalized isochromeno[4,3-b]indole skeleton with a wide diversity in substituents. The reaction features reliable scalability, flexibility of structural modification, and wide substrate scope as well as operational simplicity, and it can avoid time-consuming and costly syntheses, tedious work-up, and isolation of intermediate. (C) 2014 Elsevier Ltd. All rights reserved.
• Oligosaccharide Assisted Approach: An Efficient and Facile Access to Isochromeno [4,3-b] Indoles Derivatives in the Presence of Beta Cyclodextrin
  作者：Akhilesh Kumar、Pragati Rai、Vijay B. Yadav、I. R. Siddiqui

  DOI：10.1007/s10562-018-2592-0

  日期：2019.1

  A completely eco-friendly and straightforward protocol for the biologically important isochromeno[4,3-b]indoles derivatives has been developed employing beta cyclodextrin in aqueous medium. This documented strategy includes the elimination of hazardous catalysts and volatile organic solvents. Additionally this protocol highlights environmentally benign reaction conditions, short reaction times, operational

  在水性介质中使用 β 环糊精开发了一种完全环保且直接的生物重要异色烯 [4,3-b] 吲哚衍生物的方案。这个记录在案的策略包括消除危险的催化剂和挥发性有机溶剂。此外，该方案突出了环境友好的反应条件、反应时间短、操作简单、易于后处理和纯化程序以及产品的良好收率。