3-(4-hydroxyphenyl)propionic acid butyl ester

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-(4-hydroxyphenyl)propionic acid butyl ester
• 英文别名: Butyl 3-(4-hydroxyphenyl)propanoate
• 化学式: C₁₃H₁₈O₃
• 分子量: 222.284
• InChiKey: BQAOUQHHGGJEHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(4-hydroxyphenyl)propionic acid butyl ester 在 Agaricus bisporus 、 氧气 作用下， 以 aq. phosphate buffer 、 二氯甲烷 为溶剂， 反应 24.0h， 以98%的产率得到3-(3,4-dihydroxyphenyl)propanoic acid butyl ester
  参考文献：
  名称：

  Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity

  摘要：

  Catechol derivatives with lipophilic properties have been selectively synthesized by tyrosinase in high yield avoiding long and tedious protection/deprotection steps usually required in traditional procedures. The synthesis was effective also with immobilized tyrosinase able to perform for more runs. The novel catechols were evaluated against influenza A virus, that continue to represent a severe threat worldwide. A significant antiviral activity was observed in derivatives characterized by antioxidant activity and long carbon alkyl side-chains, suggesting the possibility of a new inhibition mechanism based on both redox and lipophilic properties. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.10.026
• 作为产物：
  描述：

  对羟基苯丙酸 、 正丁醇 在 三甲基氯硅烷 作用下， 反应 24.0h， 以100%的产率得到3-(4-hydroxyphenyl)propionic acid butyl ester
  参考文献：
  名称：

  Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses

  摘要：

  Hydroxytyrosol and dihydrocaffeoyl catechols with lipophilic properties have been synthesized in high yield using tyrosinase immobilized on multi-walled carbon nanotubes by the Layer-by-Layer technique. All synthesized catechols were evaluated against a large panel of DNA and RNA viruses, including Poliovirus type 1, Echovirus type 9, Herpes simplex virus type 1 (HSV-1), Herpes simplex virus type 2 (HSV-2), Coxsackievirus type B3 (Cox B3), Adenovirus type 2 and type 5 and Cytomegalovirus (CMV). A significant antiviral activity was observed in the inhibition of HSV-1, HSV-2, Cox B3 and CMV. The mechanism of action of the most active dihydrocaffeoyl derivative was investigated against a model of HSV-1 infection. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.07.061

文献信息

• [EN] UREA-BASED PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) INHIBITORS FOR IMAGING AND THERAPY<br/>[FR] INHIBITEURS DE L'ANTIGÈNE MEMBRANAIRE SPÉCIFIQUE DE LA PROSTATE (PSMA) À BASE D'URÉE, POUR IMAGERIE ET TRAITEMENT THÉRAPEUTIQUE
  申请人：FIVE ELEVEN PHARMA INC

  公开号：WO2017116994A1

  公开（公告）日：2017-07-06

  The present invention relates to compounds according to Formula I and Formula IV. These compounds display very good binding affinities to the PSMA binding sites. They can be labeled with [68Ga]GaCl3 with high yields and excellent radiochemical purity. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I or Formula IV, or a pharmaceutically acceptable salt thereof.

  本发明涉及符合式I和符合式IV的化合物。这些化合物显示出非常好的结合亲和力，能与PSMA结合位点结合。它们可以用[68Ga]GaCl3标记，产率高，放射化学纯度优秀。本发明还涉及包含药用可接受载体和符合式I或符合式IV的化合物，或其药用可接受盐的药物组合物。
• Stabilized polyoxyalkylene polyether polyols and polyurethane foams prepared therefrom
  申请人：ATLANTIC RICHFIELD COMPANY

  公开号：EP0122989A1

  公开（公告）日：1984-10-31

  Polyoxyalkylene polyether polyols are stabilized against oxidative degradation by incorporating therein a synergistic stabilizing composition containing (1) a mixture of butylated phenols consisting of 2-tertiary butyl phenol, 3,5-ditertiary butyl-4-hydroxyhydrocinnamate and 1,6-hexamethylene bis (3,5-ditertiary-butyl-4-hydroxyhydrocinnamate) or tetrakis [methylene(3,5-ditertiary butyl-4-hydroxyhydrocinna mate)] methane (2) a p,p'-dialkyldiphenylamine such as p,p'- dioctyldiphenylamine and (3) a phenothiazine compound. Polyurethane foams are stabilized against scorching when the stabilized polyols are utilized in the foam preparation or the stabilizing composition is added with other reactants.

  通过在聚氧亚烷基聚醚多元醇中加入一种协同稳定组合物，可稳定聚氧亚烷基聚醚多元醇不发生氧化降解，该组合物包含：(1) 丁基化苯酚混合物，由 2-叔丁基苯酚、3,5-二叔丁基-4-羟基氢肉桂酸酯和 1、(1) 由 2-叔丁基苯酚、3,5-二叔丁基-4-羟基肉桂酸丁酯和 1,6-六亚甲基双（3,5-二叔丁基-4-羟基氢肉桂酸丁酯）或四[亚甲基（3,5-二叔丁基-4-羟基肉桂酸丁酯）]甲烷组成的丁基化苯酚混合物 (2) 对,对'-二烷基二苯胺，如对,对'-二辛基二苯胺 (3) 吩噻嗪化合物。当在泡沫制备过程中使用稳定多元醇或将稳定组合物与其他反应物一起添加时，聚 氨酯泡沫可防止烧焦。
• Repeating block, oligomer-free, polyphase, thermoformable polyurethanes and method of preparation thereof
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0218815A2

  公开（公告）日：1987-04-22

  Polyphase, transparent, polyblock, oligomer-free, segmented urethane polymers are disclosed which are eminently suited for use in medical devices such as blood bags, etc., and are deriveable from chain extenders, free diisocyanate molecules and prepolymers consisting essentially of linear molecules which are terminated at each end by isocyanate groups. The prepolymer molecules consist of n branched, polyether glycol residues joined through intervening carbamate groups with (n+1) diisocyanate residues, n ranging from about 1 to 4 and having an average value of less than 2. The polyether glycols have molecular weights of from about 1000 to about 6000 and are methylol-terminated chains of alkylene oxide units. Importantly, the final polymers are free of domain crystallinity.

  本发明公开了多相、透明、多嵌段、无低聚物、分段聚氨酯聚合物，这些聚合物非常适合用于医疗设备，如血袋等，可从扩链剂、游离二异氰酸酯分子和主要由线性分子组成的预聚物中提取，线性分子的两端均由异氰酸酯基团终止。预聚物分子由 n 个支化的聚醚二醇残基组成，通过中间的氨基甲酸酯基团与 (n+1) 个二异氰酸酯残基连接，n 介于 1 到 4 之间，平均值小于 2。重要的是，最终的聚合物不含畴结晶。
• Hot melt adhesives
  申请人：SHELL OIL COMPANY

  公开号：EP0301867A2

  公开（公告）日：1989-02-01

  A hot melt adhesive comprising an optionally modified polymer, an optionally modified butene-1 polymer, a stabilizer and optionally one or more of a tackifying resin, a wax and an atactic propylene polymer.

  一种热熔粘合剂，由可选改性聚合物、可选改性丁烯-1 聚合物、稳定剂和可选增粘脂、蜡和无规丙烯聚合物中的一种或多种组成。
• Process for preparing polysubstituted piperazinones
  申请人：THE B.F. GOODRICH COMPANY

  公开号：EP0361536A1

  公开（公告）日：1990-04-04

  A particular branched chain polyalkylenepolyamine ("PAPA") having plural amine groups including a secondary amine group intermediate terminal free primary amine groups (that is, neither one is hindered), and having at least two C atoms between each group, may be selectively cyclized with a ketoform reaction to form a polysubstit­uted piperazinone ("PSP"), with specific directivity. Such PSPs are linked to a triazine nucleus to yield pip­erazinone-triazine ("PIP-T") compounds which are excel­lent stabilizers for polyolefins and other light-degrad­able polymers. Certain acyclic polyalkylenepolyamines may have a PIP-T substituent at each N atom forming pend­ant PIP-Ts ("P[PIP-T]" for brevity) which are also excel­lent stabilizers, and like some of the PIP-Ts, some P[PIP-T]s provide photostabilization without noticeably interfering with the color of films and fibers provided by even pastel-colored pigments and dyes.

  一种特殊的支链聚亚烷基庚胺（"PAPA"）具有多个胺基团，其中包括一个仲胺基团和一个末端游离伯胺基团（即二者均不受阻），并且每个基团之间至少有两个 C 原子，可以通过酮化反应选择性地环化，形成具有特定指向性的多取代哌嗪酮（"PSP"）。这种 PSP 与三嗪核相连，生成哌嗪酮-三嗪（"PIP-T"）化合物，是聚烯烃和其他光降解聚合物的优良稳定剂。某些无环聚亚烷基多胺可能在每个 N 原子上都有一个 PIP-T 取代基，形成悬垂 PIP-T（简写为 "P[PIP-T]"），这也是非常好的稳定剂，而且与某些 PIP-T 一样，某些 P[PIP-T]s 在提供光稳定的同时，甚至不会明显干扰粉彩颜料和染料所提供的薄膜和纤维的颜色。