1-methyl-3-(1-(1-methylindol-3-yl)hexyl)-indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-methyl-3-(1-(1-methylindol-3-yl)hexyl)-indole
• 英文别名: 1-Methyl-3-[1-(1-methylindol-3-yl)hexyl]indole
• 化学式: C₂₄H₂₈N₂
• 分子量: 344.5
• InChiKey: BQNAMLJWDLKYBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  1-甲基吲哚 、 1-己炔 在 五羰基溴铼(I) 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以89%的产率得到1-methyl-3-(1-(1-methylindol-3-yl)hexyl)-indole
  参考文献：
  名称：

  Rhenium-Catalyzed Regiodivergent Addition of Indoles to Terminal Alkynes

  摘要：

  An efficient rhenium-catalyzed site-switchable addition of indoles to terminal alkynes is described. A variety of bisindolylalkane derivatives are expeditiously synthesized in high yields with excellent regioselectivity. Preliminary mechanistic study sheds light on the observed regiodivergent addition.

  DOI：

  10.1021/ol203199m

文献信息

• <i>N</i> ‐bromosuccinimide catalyzed condensations of indoles with carbonyl compounds under solvent‐free conditions
  作者：Hideko Koshima、Wataru Matsusaka

  DOI：10.1002/jhet.5570390539

  日期：2002.9

  NBS was found to be an efficient catalyst for condensations of indoles with aldehydes or ketones in the absence of solvent.

  人们发现，在没有溶剂的情况下，NBS是吲哚与醛或酮缩合的有效催化剂。
• Rhenium-Catalyzed Regiodivergent Addition of Indoles to Terminal Alkynes
  作者：Dexin Xia、Yin Wang、Zhenting Du、Qi-Yu Zheng、Congyang Wang

  DOI：10.1021/ol203199m

  日期：2012.1.20

  An efficient rhenium-catalyzed site-switchable addition of indoles to terminal alkynes is described. A variety of bisindolylalkane derivatives are expeditiously synthesized in high yields with excellent regioselectivity. Preliminary mechanistic study sheds light on the observed regiodivergent addition.