N-carbethoxy-L-cysteine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-carbethoxy-L-cysteine
• 英文别名: (2R)-2-(ethoxycarbonylamino)-3-sulfanylpropanoic acid
• 化学式: C₆H₁₁NO₄S
• 分子量: 193.224
• InChiKey: RUPSHIGZHIHLOO-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  76.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N,N'-bis-carbethoxy-L-cystine 在 三(2-羰基乙基)磷盐酸盐 作用下， 以 水 为溶剂， 反应 0.75h， 以52%的产率得到N-carbethoxy-L-cysteine
  参考文献：
  名称：

  L-半胱氨酸的双重前药：对乙酰氨基酚诱导的小鼠肝毒性的不同保护作用。

  摘要：

  合成了一系列的L-半胱氨酸双药，旨在在体内释放L-半胱氨酸并刺激谷胱甘肽（GSH）的生物合成。为了评估这些双重前药的肝保护效力，对雄性Swiss-Webster小鼠腹膜内（ip）给予对乙酰氨基酚（ACP）（2.45 mmol / kg（360 mg / kg））。在ACP之前1 h给予前药（2.50 mmol / kg，ip或1.25 mmol / kg，ip，视方案而定）。在ACP后0.5小时给予补充剂量的前药（2.5 mmol / kg，腹膜内或ipA或1.25 mmol / kg，取决于方案）。将ACP给药后24小时的血浆丙氨酸氨基转移酶（ALT）值转换为对数，并绘制和比较各组对数值的95％和99％置信区间。通过血浆ALT水平的减弱程度来评估肝保护作用。在这些多剂量方案中，发现使用2％羧甲基纤维素作为前药的载体是有害的；因此，将前药溶解在稀碱水溶液中，并调节pH以进行给药。当在ACP之前1

  DOI：

  10.1002/jbt.10044

文献信息

• Ecological Base-Conditioned Preparation of Dipeptides Using Unprotected α-Amino Acids Containing Hydrophilic Side Chains
  作者：Tetsuya Ezawa、Seunghee Jung、Yuya Kawashima、Takuya Noguchi、Nobuyuki Imai

  DOI：10.1246/bcsj.20170035

  日期：2017.6.15

  The coupling reactions of 3-phenylpropanoic acid and N-carboxybenzyl α-amino acids with unprotected α-amino acids containing hydrophilic side chains such as aliphatic alcohol, aromatic alcohol, thiol, carboxylic acid, and amide afforded the corresponding amides in 66–96% yield without racemization via the corresponding mixed carbonic carboxylic anhydrides under basic conditions through an ecological

  3-苯基丙酸和N-羧基苄基α-氨基酸与含有亲水侧链的未保护α-氨基酸如脂肪醇、芳香醇、硫醇、羧酸和酰胺的偶联反应得到66-96%的相应酰胺通过生态绿色合成方法，在碱性条件下通过相应的混合碳酸酐不发生外消旋化的收率。
• Convenient Peptide Synthesis Using Unprotected α-Amino Acids Containing Another Hydrophilic Moiety under Basic Conditions
  作者：Takuya Noguchi、Seunghee Jung、Nobuyuki Imai

  DOI：10.1246/cl.2012.577

  日期：2012.6.5

  Carboxylic acids 1 and 7 reacted effectively with unprotected α-amino acids 2 containing another hydrophilic moiety under basic conditions via activation by ethyl chloroformate and triethylamine to afford the corresponding amides in 74–99% yields.

  在碱性条件下，羧酸 1 和 7 通过氯甲酸乙酯和三乙胺的活化作用，与含有另一个亲水分子的未受保护的 α- 氨基酸 2 发生有效反应，生成相应的酰胺，产率为 74-99%。
• PHOTO-CURING MATERIAL MANUFACTURING METHOD, AND PHOTO-CURING MATERIAL AND ARTICLE
  申请人：Asahi Glass Company Limited

  公开号：EP2360195A1

  公开（公告）日：2011-08-24

  To provide a photocurable material which can form a cured product having a high transparency and a high refractive index, a process for producing the material easily, and an article having a high transparency and a high refractive index. The photocurable material is obtained by a production process comprising (i) a step of reacting a polymerizable component (A) comprised of at least one type of a compound (a) having a (meth)acryloyloxy group, and a compound (B) having a mercapto group and a carboxy group to obtain a surface modifier (C) which has the carboxy group derived from the compound (B) at a terminal, (ii) a step of modifying the surface of inorganic fine particles (D) with the surface modifier (C) to obtain surface-modified inorganic fine particles (E), and (iii) a step of obtaining a photocurable material which contains the surface-modified inorganic fine particles (E), a polymerizable component (F) comprised of at least one type of a compound (f) having a (meth)acryloyloxy group, and a photopolymerization initiator (G).

  提供一种可形成具有高透明度和高折射率的固化物的光固化材料、一种易于生产该材料的工艺以及一种具有高透明度和高折射率的制品。 这种光固化材料是通过以下生产工艺获得的： (i) 第一步：使由至少一种具有(甲基)丙烯酰氧基的化合物(a)和具有巯基和羧基的化合物(B)组成的可聚合组分(A)与表面改性剂(C)反应，表面改性剂(C)的末端具有来自化合物(B)的羧基、(ii) 用表面改性剂（C）改性无机微粒（D）的表面，以获得表面改性无机微粒 （E），以及 (iii) 获得光固化材料的步骤，该材料包含表面改性无机微粒（E）、由至少一种具有 （甲基）丙烯酰氧基的化合物（f）和光聚合引发剂（G）组成的可聚合组分（F）。
• PROCESS FOR PRODUCING PHOTOCURABLE MATERIAL, PHOTOCURABLE MATERIAL AND ARTICLE
  申请人：NOMOTO Hideo

  公开号：US20110237703A1

  公开（公告）日：2011-09-29

  To provide a photocurable material which can form a cured product having a high transparency and a high refractive index, a process for producing the material easily, and an article having a high transparency and a high refractive index. The photocurable material is obtained by a production process comprising (i) a step of reacting a polymerizable component (A) comprised of at least one type of a compound (a) having a (meth)acryloyloxy group, and a compound (B) having a mercapto group and a carboxy group to obtain a surface modifier (C) which has the carboxy group derived from the compound (B) at a terminal, (ii) a step of modifying the surface of inorganic fine particles (D) with the surface modifier (C) to obtain surface-modified inorganic fine particles (E), and (iii) a step of obtaining a photocurable material which contains the surface-modified inorganic fine particles (E), a polymerizable component (F) comprised of at least one type of a compound (f) having a (meth)acryloyloxy group, and a photopolymerization initiator (G).
• US8207242B2
  申请人：——

  公开号：US8207242B2

  公开（公告）日：2012-06-26