N-[2-(acetylamino)ethyl]acrylamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[2-(acetylamino)ethyl]acrylamide
• 英文别名: N-(2-acetamidoethyl)prop-2-enamide
• 化学式: C₇H₁₂N₂O₂
• 分子量: 156.184
• InChiKey: TXUXGAPNYCRQJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-乙酰-L-半胱氨酸 、 N-[2-(acetylamino)ethyl]acrylamide 在 ammonium hydroxide 作用下， 以 水 为溶剂， 以28%的产率得到
  参考文献：
  名称：

  硫醇基迈克尔型加成。系统评估其控制因素

  摘要：

  本文是关于控制这种流行的生物共轭反应动力学和产物稳定性的因素。我们证明a）硫醇pKa，即硫醇盐的量，是亲核试剂反应动力学的唯一决定因素；b）产物降解主要通过水解（而非硫醇交换）发生，并且对于反应最迅速的亲电试剂更为突出。在分子设计方面，丙烯酰胺和低pKa硫醇作为反应伙伴出现，为稳定性和反应速率提供了最佳折衷方案。

  DOI：

  10.1016/j.tet.2020.131637
• 作为产物：
  描述：

  N-乙酰基乙二胺 、 丙烯酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以53%的产率得到N-[2-(acetylamino)ethyl]acrylamide
  参考文献：
  名称：

  硫醇基迈克尔型加成。系统评估其控制因素

  摘要：

  本文是关于控制这种流行的生物共轭反应动力学和产物稳定性的因素。我们证明a）硫醇pKa，即硫醇盐的量，是亲核试剂反应动力学的唯一决定因素；b）产物降解主要通过水解（而非硫醇交换）发生，并且对于反应最迅速的亲电试剂更为突出。在分子设计方面，丙烯酰胺和低pKa硫醇作为反应伙伴出现，为稳定性和反应速率提供了最佳折衷方案。

  DOI：

  10.1016/j.tet.2020.131637

文献信息

• STIMULI RESPONSIVE COMPOSITIONS FOR IRON CHELATION
  申请人：Xiong May Pang

  公开号：US20160184344A1

  公开（公告）日：2016-06-30

  The present technology provides new compositions comprising at least one cross-linked co-polymer. In some embodiments, the polyacrylamide co-polymer comprises water soluble subunits, cross-linking subunits, and iron chelating subunits. In other embodiments, the co-polymer comprises water soluble units, cross-linking subunits, and substituted subunits, which can be conjugated with iron-chelating agents. When these new particles are exposed to certain environments, such the presence of strong acids or oxidation agents, these particles are capable of breaking up so that the iron chelating agents can chelate iron or other metals from their environments. Methods to prepare these new compositions are also provided. These compositions or compositions comprising nanogels of the present technology may be used to treat metal overload conditions such as iron overload resulting from chronic transfusions.

  目前的技术提供了包含至少一种交联共聚物的新组合物。在某些实施例中，聚丙烯酰胺共聚物包括水溶性亚基、交联亚基和铁螯合亚基。在其他实施例中，共聚物包括水溶性单元、交联亚基和取代亚基，这些亚基可以与螯合铁的试剂结合。当这些新颗粒暴露在某些环境中，如强酸或氧化剂的存在时，这些颗粒能够分解，以便铁螯合试剂可以从它们的环境中螯合铁或其他金属。还提供了制备这些新组合物的方法。这些组合物或包含本技术的纳米凝胶的组合物可用于治疗金属过载症状，例如由于慢性输血导致的铁过载。
• Ion binding polymers and uses thereof
  申请人：Vifor (International) Ltd.

  公开号：US10485821B2

  公开（公告）日：2019-11-26

  The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.

  本发明提供了治疗离子失衡的方法和组合物。特别是，本发明提供了包含钾结合聚合物的组合物及其药物组合物。本文公开了聚合物和药物组合物用于治疗和/或预防的方法。这些方法的例子包括治疗高钾血症，如肾功能衰竭引起的高钾血症和/或使用引起高钾血症的药物。
• POLYMERIZABLE LIQUID CRYSTAL COMPOUND, POLYMERIZABLE LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTALLINE POLYMER, AND OPTICAL ANISOTROPIC ARTICLE
  申请人：Sakamoto Kei

  公开号：US20100258764A1

  公开（公告）日：2010-10-14

  A polymerizable liquid crystal compound shown by the following formula (I), a polymerizable liquid crystal composition that includes the polymerizable liquid crystal compound and a chiral compound polymerizable with the polymerizable liquid crystal compound, a liquid crystalline polymer obtained by polymerizing the polymerizable liquid crystal compound or the polymerizable liquid crystal composition, and an optical anisotropic article that includes the liquid crystalline polymer. The polymerizable liquid crystal compound shows a liquid crystal phase over a wider temperature range, is chemically stable, can be inexpensively produced, and has a wide selective reflection wavelength band Δλ (i.e., a large value Δn). The polymerizable liquid crystal composition includes the polymerizable liquid crystal compound, the liquid crystalline polymer is obtained by polymerizing the polymerizable liquid crystal compound or the polymerizable liquid crystal composition, and the optical anisotropic article includes the liquid crystalline polymer. wherein Y 1 to Y 6 represent —O—, —O—C(═O)—, —C(═O)—O—, or the like, G 1 and G 2 represent divalent aliphatic groups having 1 to 20 carbon atoms, Z 1 and Z 2 represent an alkenyl group having 2 to 10 carbon atoms or the like, A 1 and A 2 represent divalent organic groups A having 1 to 30 carbon atoms, X 1 to X 8 represent a hydrogen atom or the like, and a and b represent 0 or 1.
• POLYMERIZABLE LIQUID CRYSTAL COMPOUNDS, POLYMERIZABLE LIQUID CRYSTAL COMPOSITIONS, LIQUID CRYSTALLINE POLYMERS AND OPTICALLY ANISOTROPIC MATERIALS
  申请人：Sakamoto Kei

  公开号：US20110140041A1

  公开（公告）日：2011-06-16

  A polymerizable liquid crystal compound shown by the following formula, a polymerizable liquid crystal composition that includes the polymerizable liquid crystal compound and a chiral compound polymerizable with the polymerizable liquid crystal compound, a liquid crystalline polymer obtained by polymerizing the polymerizable liquid crystal compound or the polymerizable liquid crystal composition, and an optically anisotropic article that includes the liquid crystalline polymer, are disclosed. wherein Y 1 to Y 6 represent —O—C(═O)— or the like, G 1 and G 2 represent a divalent aliphatic group having 1 to 20 carbon atoms or the like, Z 1 and Z 2 represent an alkenyl group having 2 to 10 carbon atoms or the like, A 1 and A 2 represent a divalent organic group having 1 to 30 carbon atoms, M 1 and M 2 represent a substituted or unsubstituted 2,6-naphthylene group or a substituted or unsubstituted 1,4-phenylene group, provided that at least one of M 1 and M 2 represents a substituted or unsubstituted 2,6-naphthylene group, L 1 and L 2 represent a hydrogen atom or the like, and a and b are 0 or 1. A polymerizable liquid crystal compound that shows a liquid crystal phase over a wide temperature range, is chemically stable, can be produced inexpensively, and has a wide selective reflection wavelength band Δλ (i.e., a large value Δn); a polymerizable liquid crystal composition that includes the compound; a liquid crystalline polymer; and a optically anisotropic article that includes the liquid crystalline polymer as a constituting material; can be provided.
• POLYMERIZABLE LIQUID CRYSTAL COMPOUND, POLYMERIZABLE LIQUID CRYSTAL COMPOSITION, POLYMER AND FILM
  申请人：KATOH SHUNYA

  公开号：US20110237768A1

  公开（公告）日：2011-09-29

  A polymerizable liquid crystal compound represented by formula (I) is disclosed. R 0 and R 1 represent a hydrogen atom, or a C 1-4 alkyl group, provided that at least one of R 0 and R 1 represent a C 1-4 alkyl group; A 0 , A1, B 0 and B 1 represent a single bond, or a divalent linking group having a cyclic structure; X 0 , X 1 , Y 0 and Y 1 represent a single bond, —O—, —S—, —OCO—, —COO—, —OCOO—, —NR 2 CO—, —CONR 2 —, —OCONR 2 —, —NR 2 COO—, —NR 2 CONR 2 —, —C═N— or —N═C—; Q 0 and Q 1 a single bond or a divalent aliphatic group; Z 0 and Z 1 represent a hydrogen atom, cyano, halogen atom or polymerizable group; and n and m each independently represent an integer of from 0 to 2.