H-Asp-(tBu)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Asp-(tBu)
• 英文别名: (3S)-3-amino-5,5-dimethyl-4-oxohexanoic acid
• 化学式: C₈H₁₅NO₃
• 分子量: 173.212
• InChiKey: NCVACJDYSJJMOA-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  H-Asp-(tBu) 、 2,7-di(trimethylsilylethynyl)-Fmoc-N-hydroxysuccinimide ester 在 sodium carbonate 作用下， 以 四氢呋喃 为溶剂， 生成 2,7-di(trimethylsillylethynyl)-Fmoc-Asp(tBu)-OH
  参考文献：
  名称：

  WO2023/120646

  摘要：

  公开号：

文献信息

• Solid phase peptide synthesis via side chain attachment
  申请人：Chemical & Biopharmaceutical Laboratories of Patras S.A.

  公开号：US09388212B2

  公开（公告）日：2016-07-12

  The present application discloses peptides and peptaibols of high purity may be obtained by solid phase peptide synthesis using as the starting resin hydroxy amino acids, hydroxy amino acid amides, hydroxy amino alcohols or small peptides containing hydroxy amino acids attached to polymers through their side chain.

  本申请公开了通过固相肽合成可获得高纯度的肽和肽类物质，其使用羟基氨基酸、羟基氨基酸酰胺、羟基氨基醇或含有羟基氨基酸的小肽作为起始树脂，通过它们的侧链连接到聚合物上。
• PRO-DRUGS OF (E)-7-(3-(2-AMINO-1-FLUOROETHYLIDENE)PIPERIDIN-1-YL)-1-CYCLOPROPYL-6-FLUORO-8-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
  申请人：MACIELAG Mark

  公开号：US20110172193A1

  公开（公告）日：2011-07-14

  The present invention is directed to pro-drugs of (E)-7-(3-(2-amino-1-fluoroethylidene)piperidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, pharmaceutical compositions containing them and the use of said pro-drugs and pharmaceutical compositions as antimicrobial agents against pathogenic microorganisms, particularly against resistant microbes.

  本发明涉及(E)-7-(3-(2-氨基-1-氟乙烯基)哌啶-1-基)-1-环丙基-6-氟-8-甲氧基-4-氧代-1,4-二氢喹啉-3-羧酸的前药、含有它们的制药组合物以及所述前药和制药组合物作为抗微生物药物，特别是对抗耐药微生物的用途。
• Sialyltransferase inhibitors and uses thereof
  申请人：Academia Sinica

  公开号：US10889611B2

  公开（公告）日：2021-01-12

  Disclosed herein are novel sialyltransferase inhibitors, and compositions and methods for treating diseases and/or conditions associated with the activation of sialyltransferase, such as a cancer, an immune disease or an inflammatory disease.

  本文公开了新型硅氨基转移酶抑制剂，以及用于治疗与硅氨基转移酶活化相关的疾病和/或病症（如癌症、免疫性疾病或炎症性疾病）的组合物和方法。
• PROTEIN KINASE MODULATING COMPOUNDS AND METHODS FOR MAKING AND USING THEM
  申请人：Wrasidlo Wolfgang

  公开号：US20100209488A1

  公开（公告）日：2010-08-19

  The invention provides compositions, e.g., small molecules, that disrupt the activity of protein kinases, including constitutively activated protein kinases, such as kinases constitutively activated through mutations, and kinases in their native inactivated state, and methods for making and using them. In one aspect, compositions of the invention bind a protein kinase in its inactive conformation involving the conserved asparagine-phenylalanine-glycine residue motif, or “Asp-Phe-Gly” or “DFG” motif, of the activation loop in the allosteric binding site. The small molecule protein kinase inhibitors of the invention comprise or are derivatives or analogs of oxadiazoles, thiadiazoles, oxazoles, thiazoles, arylamides, quinolones, pyrazoles, pyrazolones, imides, pyrolles, imidazoles and/or triazoles.
• US7498436B2
  申请人：——

  公开号：US7498436B2

  公开（公告）日：2009-03-03