2-(4-bromophenyl)-5-methyl-3-(1H-1,2,4-triazol-3-yl)thiazolidin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-bromophenyl)-5-methyl-3-(1H-1,2,4-triazol-3-yl)thiazolidin-4-one
• 英文别名: 2-(4-bromophenyl)-5-methyl-3-(1H-1,2,4-triazol-5-yl)-1,3-thiazolidin-4-one
• 化学式: C₁₂H₁₁BrN₄OS
• 分子量: 339.216
• InChiKey: UTHAMBKVGCXWAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  87.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1H-1,2,4-三唑 、 硫代乳酸 、 对溴苯甲醛 在 十六烷基三甲基溴化铵 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 0.42h， 以90%的产率得到2-(4-bromophenyl)-5-methyl-3-(1H-1,2,4-triazol-3-yl)thiazolidin-4-one
  参考文献：
  名称：

  Organocatalysis in aqueous micellar medium: a new protocol for the synthesis of [1,2,4]-triazolyl-thiazolidinones

  摘要：

  A new environmentally friendly methodology for the efficient synthesis of biologically significant triazole thiazolidinone hybrids in aqueous medium, using acetic acid as an organocatalyst in the presence of cetyltrimethylammonium bromide (CTAB) surfactant has been developed for the first time. The effect of several surfactants on the yield and completion time of the reaction was investigated and it was found that the use of CTAB at 60 degrees C gave the best results (79-96% in 20 min-35 min) for the synthesis of the target compounds. (c) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.09.030

文献信息

• Organocatalysis in aqueous micellar medium: a new protocol for the synthesis of [1,2,4]-triazolyl-thiazolidinones
  作者：Mandavi Singh、Mohammad Saquib、Shyam Babu Singh、Swastika Singh、Preyas Ankit、Shahin Fatma、Jagdamba Singh

  DOI：10.1016/j.tetlet.2014.09.030

  日期：2014.11

  A new environmentally friendly methodology for the efficient synthesis of biologically significant triazole thiazolidinone hybrids in aqueous medium, using acetic acid as an organocatalyst in the presence of cetyltrimethylammonium bromide (CTAB) surfactant has been developed for the first time. The effect of several surfactants on the yield and completion time of the reaction was investigated and it was found that the use of CTAB at 60 degrees C gave the best results (79-96% in 20 min-35 min) for the synthesis of the target compounds. (c) 2014 Elsevier Ltd. All rights reserved.