乙基2-氨基-5-羟基-1-甲基-6-氧代-1,6-二氢-4-嘧啶羧酸酯 | 729608-50-8

• 物质功能分类: 医药中间体 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 乙基2-氨基-5-羟基-1-甲基-6-氧代-1,6-二氢-4-嘧啶羧酸酯
• 英文名称: Ethyl 2-amino-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylate
• 英文别名: ethyl 2-amino-5-hydroxy-1-methyl-6-oxopyrimidine-4-carboxylate
• CAS: 729608-50-8
• 化学式: C₈H₁₁N₃O₄
• 分子量: 213.19
• InChiKey: WBLCUCXNMOHTPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• HIV integrase inhibitors
  申请人：——

  公开号：US20040204498A1

  公开（公告）日：2004-10-14

  Compounds useful for treating HIV are disclosed having the general formula 1 wherein R 1 , R 2 , and B are as defined in the specification. Compositions containing the compounds and methods for using the compounds to inhibit HIV are also disclosed.

  本发明揭示了用于治疗HIV的化合物，其具有以下一般式1，其中R1，R2和B在说明书中定义。还揭示了含有这些化合物的组合物以及使用这些化合物抑制HIV的方法。
• THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：GRIFFIOEN Gerard

  公开号：US20090054410A1

  公开（公告）日：2009-02-26

  This invention provides specifically substituted 1,2,4-thiadiazole derivatives for use in the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease. This invention also provides various methods for producing such substituted 1,2,4-thiadiazole derivatives.
• US7135467B2
  申请人：——

  公开号：US7135467B2

  公开（公告）日：2006-11-14
• US8541406B2
  申请人：——

  公开号：US8541406B2

  公开（公告）日：2013-09-24
• [EN] HIV INTEGRASE INHIBITORS<br/>[FR] INHIBITEURS D'INTEGRASE HIV
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2004062613A2

  公开（公告）日：2004-07-29

  Compounds useful for treating HIV are disclosed having the general formula (I): wherein R1, R2, and B are as defined in the specification. Compositions containing the compounds and methods for using the compounds to inhibit HIV are also disclosed.