Zirconium triflate-catalyzed reactions of indole, 1-methylindole, and pyrrole with α,β-unsaturated ketone
作者:Min Shi、Shi-Cong Cui、Qing-Jiang Li
DOI:10.1016/j.tet.2004.05.087
日期:2004.7
The Zr(OTf)4-catalyzed reaction of indole, 1-methylindole or pyrrole with α,β-unsaturated ketone generated the corresponding trisindolyl-, tris(1-methylindolyl-), and trispyrrolylalkanes in moderate to high yields in the mixed solvent EtOH/H2O.
Zr(OTf)4催化吲哚,1-甲基吲哚或吡咯与α,β-不饱和酮的反应,在混合溶剂EtOH中以中等至高收率生成了相应的三吲哚基-,三(1-甲基吲哚基-)和三吡咯烷基烷烃/ H 2 O.
In situ generation of Iron(<scp>iii</scp>) dodecyl sulfate as Lewis acid-surfactant catalyst for synthesis of bis-indolyl, tris-indolyl, Di(bis-indolyl), Tri(bis-indolyl), tetra(bis-indolyl)methanes and 3-alkylated indole compounds in water
Iron(III) dodecyl sulfate as Lewis acid-surfactant catalyst was prepared in situ and effectively used in the synthesis of bis(indolyl)methanes and Michael reactions of indoles with α,β-unsaturated carbonyl compounds in water. Also, this method was used for the synthesis of 1,1,3-tri-indolyl compounds, producing good to excellent yield at room temperature.
AlCl3 as a powerful catalyst for the one-pot preparation of 1,1,3-triheteroaryl compounds
作者:Morteza Shiri、Mohammad Ali Zolfigol、Roya Ayazi-Nasrabadi
DOI:10.1016/j.tetlet.2009.10.127
日期:2010.1
A general and efficient procedure for the synthesis of 1,1,3-triheteroaryl compounds in good to excellent yield at room temperature is developed. The reaction proceeds via mixed Michael and Friedel-Crafts reactions of alpha,beta-enals or alpha,beta-enones and indoles, 2-methylfuran or 2-methylthiophene in the presence of a catalytic amount of AlCl3. (C) 2009 Elsevier Ltd. All rights reserved.