2-(Aminomethyl)-5-[4-(dimethylamino)phenyl]-1,3-thiazole-4-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(Aminomethyl)-5-[4-(dimethylamino)phenyl]-1,3-thiazole-4-carboxylic acid
• 英文别名: 2-(aminomethyl)-5-[4-(dimethylamino)phenyl]-1,3-thiazole-4-carboxylic acid
• 化学式: C₁₃H₁₅N₃O₂S
• 分子量: 277.34
• InChiKey: YDXDBRSTPTYBQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Ribosome-mediated incorporation of peptides and peptidomimetics
  申请人：ARIZON BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

  公开号：US10745705B2

  公开（公告）日：2020-08-18

  Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.

  在细胞自由翻译系统中，使用二肽-尿霉素氨基核苷酸筛选出的修饰核糖体可用于介导一种或多种肽和拟肽定点结合到蛋白质中。此外，还合成了新的荧光二肽模拟物，并将其加入蛋白质以及含有一种或多种非天然二肽的修饰蛋白质中。
• RIBOSOME-MEDIATED INCORPORATION OF PEPTIDES AND PEPTIDOMIMETICS
  申请人：Arizona Board of Regents on Behalf of Arizona State University

  公开号：US20180002709A1

  公开（公告）日：2018-01-04

  Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.
• Ribosome-Mediated Incorporation of Peptides and Peptidomimetics
  申请人：Hecht Sidney

  公开号：US20200370057A1

  公开（公告）日：2020-11-26

  Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.
• [EN] RIBOSOME-MEDIATED INCORPORATION OF PEPTIDES AND PEPTIDOMIMETICS<br/>[FR] INCORPORATION MÉDIÉE PAR LES RIBOSOMES DE PEPTIDES ET DE PEPTIDOMIMÉTIQUES
  申请人：ARIZON BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

  公开号：WO2016118877A1

  公开（公告）日：2016-07-28

  Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.