GYY4137 | 106740-08-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: GYY4137
• 英文别名: (4-Methoxyphenyl)(morpholino)phosphinodithioic acid；(4-methoxyphenyl)-morpholin-4-yl-sulfanyl-sulfanylidene-λ5-phosphane
• CAS: 106740-08-3
• 化学式: C₁₁H₁₆NO₂PS₂
• 分子量: 289.359
• InChiKey: QDSAKNAFJWRQIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  54.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  GYY4137 在 sodium hydride 作用下， 以 乙醚 、 mineral oil 为溶剂， 反应 0.92h， 以98%的产率得到sodium 4-methoxyphenyl(morpholino)phosphinodithioate
  参考文献：
  名称：

  Investigating the generation of hydrogen sulfide from the phosphonamidodithioate slow-release donor GYY4137

  摘要：

  已经阐明了缓释硫化氢供体GYY4137的两步水解分解途径。

  DOI：

  10.1039/c5md00170f
• 作为产物：
  描述：

  (4-甲氧基苯基)吗啉基-二硫代膦酸与吗啉的化合物 在 溶剂黄146 作用下， 以 水 为溶剂， 以84%的产率得到GYY4137
  参考文献：
  名称：

  Investigating the generation of hydrogen sulfide from the phosphonamidodithioate slow-release donor GYY4137

  摘要：

  已经阐明了缓释硫化氢供体GYY4137的两步水解分解途径。

  DOI：

  10.1039/c5md00170f

文献信息

• COMPOUNDS FOR PH-CONTROLLED RELEASE OF HYDROGEN SULFIDE
  申请人：Washington State University

  公开号：US20170253622A1

  公开（公告）日：2017-09-07

  The embodiments herein generally relates to compounds and methods for releasing H 2 S in a pH dependent manner. In particular, the invention provides compounds of various formulations which release H 2 S in a controlled, predictable and sustained manner upon contact with an aqueous environment, such as the circulatory system of an animal, and which are thus suitable for in vivo delivery of H 2 S.

  本文涉及一般与化合物和方法有关，用于以pH依赖方式释放H2S。具体而言，该发明提供了各种配方的化合物，这些化合物在与水性环境接触时以受控、可预测和持续的方式释放 ，例如动物的循环系统，因此适用于体内 的释放。
• MORPHOLIN-4-IUM 4 METHOXYPHENYL (MORPHOLINO) PHOSPHINODITHIOATE (GYY4137) AS A NOVEL VASODILATOR AGENT
  申请人：Moore Philip Keith

  公开号：US20100273743A1

  公开（公告）日：2010-10-28

  The invention is directed to a method of administering hydrogen sulfide (H 2 S) slowly and sustainably to an individual in need thereof comprising administering an effective amount of a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof.

  本发明涉及一种缓慢、持续地给予需要氢硫化物（H2S）的个体的方法，包括给予下列结构式所表示的化合物的有效量，或其药学上可接受的盐：
• Compounds for pH-controlled release of hydrogen sulfide
  申请人：Washington State University

  公开号：US10005801B2

  公开（公告）日：2018-06-26

  The embodiments herein generally relates to compounds and methods for releasing H2S in a pH dependent manner. In particular, the invention provides compounds of various formulations which release H2S in a controlled, predictable and sustained manner upon contact with an aqueous environment, such as the circulatory system of an animal, and which are thus suitable for in vivo delivery of H2S.

  本发明的实施方案一般涉及以 pH 值相关方式释放 H2S 的化合物和方法。特别是，本发明提供了各种配方的化合物，这些化合物在与水环境（如动物的循环系统）接触时以可控、可预测和持续的方式释放 ，因此适用于体内释放 。
• METHODS FOR TREATING VIRAL INFECTIONS USING HYDROGEN SULFIDE DONORS
  申请人：The Board of Regents of the University of Texas System

  公开号：US20150342969A1

  公开（公告）日：2015-12-03

  Certain embodiments are directed to methods of treating respiratory infection by administering an H 2 S donor.
• COMBINATIONS OF A PHOTOSENSITIZER WITH A HYDROGEN SULFIDE DONOR, THIOREDOXIN INHIBITOR OR NITROXIDE FOR USE IN PHOTODYNAMIC THERAPY
  申请人：UNIVERSITY OF EXETER

  公开号：US20170202966A1

  公开（公告）日：2017-07-20

  Compounds for use The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy