divinyl dodecanedioate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: divinyl dodecanedioate
• 英文别名: bis(ethenyl) dodecanedioate
• 化学式: C₁₆H₂₆O₄
• 分子量: 282.38
• InChiKey: PCKNLONUEZRMLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  divinyl dodecanedioate 、 维生素 C 在 immobilized lipase from Candida Antarctica 作用下， 以 丙酮 为溶剂， 反应 16.0h， 以78%的产率得到6-O-[(+)-L-ascorbic acid]-vinyl dodecanedioate
  参考文献：
  名称：

  Symmetric and Asymmetric Bolaamphiphiles from Ascorbic Acid

  摘要：

  The properties of novel bolaamphiphiles that carry epimers of vitamin C (L-ascorbic acid and/or D-isoascorbic acid) as hydrophilic head groups, and an interconnecting aliphatic C-12 chain (DD, DL, and LL) were investigated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), small-angle X-ray scattering (SAXS), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) in the solid state (anhydrous powders) and in aqueous dispersions as a function of the surfactant concentration. Upon heating, the aqueous dispersions undergo a phase transition from a hydrated semicrystalline "coagel" to a micellar phase. The results suggest that the headgroup chirality determines the formation of either inter- or intramolecular hydrogen bonds between the polar heads, which affect the phase behavior and structural properties of the nanoassemblies produced by these surfactants in water dispersions. The DSC data of aqueous dispersions were analyzed to obtain the size distribution of the pores in the coagel state.

  DOI：

  10.1021/jp204920y
• 作为产物：
  描述：

  丙酸乙烯酯 、 十二烷二酸 在 硫酸 、 mercury(II) diacetate 作用下， 反应 4.0h， 以100%的产率得到divinyl dodecanedioate
  参考文献：
  名称：

  Sucrose Derivatives Preparation using Thermomyces lanuginosus Lipase and Their Application

  摘要：

  我们固定了兰氏热霉菌脂肪酶，以催化 DMF 中的酯交换反应。这种脂肪酶是在对其他商用脂肪酶进行筛选后选出的。我们发现，制备的固定化脂肪酶特别适用于制备 6-O-酰基蔗糖，即使在 10 克的规模下也能获得较高的转化率。对几种溶剂进行了选择性酯交换反应评估。我们注意到，固定化脂肪酶在经过 5 个周期 96 小时的反应后，仍能保持 80% 以上的活性。我们还开发了一种通用方法，利用简单的结晶和沉淀过程纯化产物。此外，6-O-乙烯基二甲酰蔗糖通过自由基引发剂合成了相应的聚合物。这种蔗糖支化聚合物可进一步用于评估其生物降解性和其他生物应用。

  DOI：

  10.5012/bkcs.2014.35.2.477

文献信息

• [EN] ORGANOSILOXANE COMPOSITION HAVING HIGH REFRACTIVE INDEX AND APPLICATIONS CONTAINING THE SAME<br/>[FR] COMPOSITION D'ORGANOSILOXANE AYANT UN INDICE DE RÉFRACTION ÉLEVÉ ET APPLICATIONS LA CONTENANT
  申请人：MOMENTIVE PERFORMANCE MAT JP

  公开号：WO2016089817A1

  公开（公告）日：2016-06-09

  The invention is directed to a silicone compound of the general formula (I) and a personal care composition comprising the silicone compound (I) as described herein, and to personal care applications containing the same and processes of making the silicone compound.

  这项发明涉及一种通式（I）所示的硅氧烷化合物，以及包括所述硅氧烷化合物（I）的个人护理组合物，以及含有该硅氧烷化合物的个人护理用途和制备该硅氧烷化合物的方法。
• Exploiting enzymatic regioselectivity: a facile methodology for the synthesis of polyhydroxylated hybrid compounds
  作者：Pietro Magrone、Francesco Cavallo、Walter Panzeri、Daniele Passarella、Sergio Riva

  DOI：10.1039/c0ob00304b

  日期：——

  Polyhydroxylated hybrid molecules have been synthesized using a protocol based on the regioselective acylation of the target compounds with activated dicarboxylic acids catalyzed by Novozym-435. The procedure implies that the mixed ester derivatives prepared and isolated from the first esterification step act as acylating agents in the second esterification step.

  多羟基化的杂化分子已通过基于Novozym-435催化的目标化合物与活化的二元羧酸的选择性酰化反应的方案合成。该过程意味着，在第一步酯化反应中制备并分离得到的混合酯衍生物，在第二步酯化反应中作为酰化剂。
• MAKEUP COMPOSITION
  申请人：KERGOSIEN Guillaume

  公开号：US20110150805A1

  公开（公告）日：2011-06-23

  Composition for making up keratin fibres, such as eyelashes or eyebrows, having improved makeup-removing properties, containing in a continuous aqueous phase: an aqueous dispersion of a particular polyurethane present in an amount of solids greater than or equal to 5% by weight relative to the total weight of said composition, and said composition comprising an emulsifying system comprising less than 2% by weight of triethanolamine.

  用于制造角蛋白纤维（如睫毛或眉毛）的组合物，具有改善卸妆性能，包含在连续水相中：特定聚氨酯的水分散体，其含量固体物质量大于或等于所述组合物总重量的5%，以及所述组合物包括含有少于2%三乙醇胺的乳化系统。
• Chemo-Enzymatic Synthesis of Silybin and 2,3-Dehydrosilybin Dimers
  作者：Eva Vavříková、Jan Vacek、Kateřina Valentová、Petr Marhol、Jitka Ulrichová、Marek Kuzma、Vladimír Křen

  DOI：10.3390/molecules19044115

  日期：——

  Divalent or multivalent molecules often show enhanced biological activity relative to the simple monomeric units. Here we present enzymatically and chemically prepared dimers of the flavonolignans silybin and 2,3-dehydrosilybin. Their electrochemical behavior was studied by in situ and ex situ square wave voltammetry. The oxidation of monomers and dimers was similar, but adsorption onto the electrode and cell surfaces was different. A 1,1-diphenyl-2-picrylhydrazyl (DPPH) and an inhibition of microsomal lipoperoxidation assay were performed with same trend of results for silybin and 2,3-dehydrosilybin dimers. Silybin dimer showed better activity than the monomer, while on the contrary 2,3-dehydrosilybin dimer presented weaker antioxidant/antilipoperoxidant activity than its monomer. Cytotoxicity was evaluated on human umbilical vein endothelial cells, normal human adult keratinocytes, mouse fibroblasts (BALB/c 3T3) and human liver hepatocellular carcinoma cell line (HepG2). Silybin dimer was more cytotoxic than the parent compound and in the case of 2,3-dehydrosilybin its dimer showed weaker cytotoxicity than the monomer.

  二价或多价分子通常相对于简单的单体单位表现出增强的生物活性。本文介绍了通过酶促和化学方法制备的黄酮木酚类化合物silybin和2,3-脱氢silybin的二聚体。通过原位和外位方波伏安法研究了它们的电化学行为。单体和二聚体的氧化过程相似，但在电极和细胞表面的吸附情况则有所不同。对1,1-二苯基-2-吡喃肼（DPPH）及微粒体脂质过氧化抑制测定的实验显示，silybin和2,3-脱氢silybin的二聚体结果趋势相同。silybin二聚体的活性优于其单体，而相反，2,3-脱氢silybin的二聚体表现出比其单体更弱的抗氧化/抗脂质过氧化活性。对人脐静脉内皮细胞、正常人成人角质形成细胞、小鼠成纤维细胞（BALB/c 3T3）和人肝细胞癌细胞系（HepG2）的细胞毒性进行了评估。结果显示，silybin二聚体的细胞毒性高于母体化合物，而在2,3-脱氢silybin的情况下，其二聚体的细胞毒性弱于单体。
• 曲克芦丁酰胺类衍生物及其合成方法和用途
  申请人：河南工业大学

  公开号：CN107163096B

  公开（公告）日：2020-01-14

  本发明公开了曲克芦丁酰胺类衍生物及其制备方法和用途，属药物化学领域。该方法以曲克芦丁乙烯酯为原料，在离子液体中，反应温度40℃~70℃，分别与1,2,3,4‑四氢异喹啉类化合物或苯乙基胺、4‑氟‑苯乙基胺、苄胺化合物反应，得到曲克芦丁酰胺类衍生物，此类化合物具有抗肿瘤活性。本发明选离子液体既做溶剂又做催化剂合成曲克芦丁酰胺类衍生物，反应条件温和、操作简单，合成成本低，产率较高，为黄酮类化合物的结构修饰提供一条新的途径。