1-(1-pentenyl)-5-methyl-2,4-pyrimidinedione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(1-pentenyl)-5-methyl-2,4-pyrimidinedione
• 英文别名: 5-methyl-1-[(E)-pent-1-enyl]pyrimidine-2,4-dione
• 化学式: C₁₀H₁₄N₂O₂
• 分子量: 194.233
• InChiKey: NZDVGVFLFRHGBO-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  正戊醛 、 胸腺嘧啶 在 1,6-己二胺 、 三甲基氯硅烷 、 silver trifluoromethanesulfonate 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以88%的产率得到1-(1-pentenyl)-5-methyl-2,4-pyrimidinedione
  参考文献：
  名称：

  Facile Synthesis of N-(1-Alkenyl) Derivatives of 2,4-Pyrimidinediones

  摘要：

  N-(1-alkenyl) derivatives of 2,4-Pyrimidinediones (6 - 9) were prepared in a one pot synthesis from aldehydes and the nucleobases using trimethylsilyl trifluoromethanesulfonate (TfOTMS) as coupling reagent. Presilylation of the above nucleobases, and N-6-benzoyladenine, with excess N,O-bis(trimethylsilyl)acetamide (BSA) followed by addition of one mol eq. TfOTMS yielded the N-(1-trimethylsilyloxyalkyl) derivatives 1 - 5.

  DOI：

  10.1080/15257770008035032

文献信息

• Facile Synthesis of N-(1-Alkenyl) Derivatives of 2,4-Pyrimidinediones
  作者：Ulla Henriksen

  DOI：10.1080/15257770008035032

  日期：2000.7

  N-(1-alkenyl) derivatives of 2,4-Pyrimidinediones (6 - 9) were prepared in a one pot synthesis from aldehydes and the nucleobases using trimethylsilyl trifluoromethanesulfonate (TfOTMS) as coupling reagent. Presilylation of the above nucleobases, and N-6-benzoyladenine, with excess N,O-bis(trimethylsilyl)acetamide (BSA) followed by addition of one mol eq. TfOTMS yielded the N-(1-trimethylsilyloxyalkyl) derivatives 1 - 5.