1,1-diphenyldeca-2,9-diyn-1-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1-diphenyldeca-2,9-diyn-1-ol
• 英文别名: 1,1-Diphenyldeca-2,9-diyn-1-ol
• 化学式: C₂₂H₂₂O
• 分子量: 302.416
• InChiKey: ZNDAMPBCPAYTNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,1-diphenyldeca-2,9-diyn-1-ol 、 苄基叠氮 在 三氟甲磺酸三甲基硅酯 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 以93%的产率得到[1-benzyl-5-(hept-6-yn-1-yl)-1H-1,2,3-triazol-4-yl]diphenylmethanol
  参考文献：
  名称：

  Regioselective Rapid Synthesis of Fully Substituted 1,2,3-Triazoles Mediated by Propargyl Cations

  摘要：

  Regioselective rapid triazole syntheses at low temperature are described. Organic azides and propargyl cations generated by acids gave fully substituted 1H-1,2,3-triazoles. Most reactions could be performed in 5 min at not only rt but also -90 degrees C. Both terminal and internal alkynes were acceptable, and the sterically bulky substituents could afford the products smoothly. Various types of three-component coupling reactions were demonstrated, and the presence of allenylaminodiazonium intermediates was indicated.

  DOI：

  10.1021/ol402387w
• 作为产物：
  描述：

  二苯甲酮 、 1,8-壬二炔 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以85%的产率得到1,1-diphenyldeca-2,9-diyn-1-ol
  参考文献：
  名称：

  Regioselective Rapid Synthesis of Fully Substituted 1,2,3-Triazoles Mediated by Propargyl Cations

  摘要：

  Regioselective rapid triazole syntheses at low temperature are described. Organic azides and propargyl cations generated by acids gave fully substituted 1H-1,2,3-triazoles. Most reactions could be performed in 5 min at not only rt but also -90 degrees C. Both terminal and internal alkynes were acceptable, and the sterically bulky substituents could afford the products smoothly. Various types of three-component coupling reactions were demonstrated, and the presence of allenylaminodiazonium intermediates was indicated.

  DOI：

  10.1021/ol402387w

文献信息

• Regioselective Rapid Synthesis of Fully Substituted 1,2,3-Triazoles Mediated by Propargyl Cations
  作者：Huan Zhang、Hiroki Tanimoto、Tsumoru Morimoto、Yasuhiro Nishiyama、Kiyomi Kakiuchi

  DOI：10.1021/ol402387w

  日期：2013.10.18

  Regioselective rapid triazole syntheses at low temperature are described. Organic azides and propargyl cations generated by acids gave fully substituted 1H-1,2,3-triazoles. Most reactions could be performed in 5 min at not only rt but also -90 degrees C. Both terminal and internal alkynes were acceptable, and the sterically bulky substituents could afford the products smoothly. Various types of three-component coupling reactions were demonstrated, and the presence of allenylaminodiazonium intermediates was indicated.