3-methylglutaric anhydride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-methylglutaric anhydride
• 英文别名: 5-(4-Carboxy-3-methylbutanoyl)oxy-3-methyl-5-oxopentanoic acid
• 化学式: C₁₂H₁₈O₇
• 分子量: 274.271
• InChiKey: NTVLILWXLOBPJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3-methylglutaric anhydride 在 硼烷四氢呋喃络合物 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 生成 N-(9-ethyl-9H-carbazol-3-yl)-5-hydroxy-3-methylpentanamide
  参考文献：
  名称：

  CONDENSED HETEROCYCLIC COMPOUND

  摘要：

  公开号：

  EP2759533B1

文献信息

• [EN] COSMETIC USES AND METHODS FOR INDOLINE GRANZYME B INHIBITOR COMPOSITIONS<br/>[FR] UTILISATIONS ET PROCÉDÉS COSMÉTIQUES POUR DES COMPOSITIONS D'INHIBITEUR D'INDOLINE GRANZYME B
  申请人：VIDA THERAPEUTICS INC

  公开号：WO2014153667A1

  公开（公告）日：2014-10-02

  Cosmetic uses and methods for indoline granzyme B inhibitor compounds in compositions with a cosmetically acceptable carrier. Uses and methods for treating, reducing or inhibiting the appearance of ageing in the skin are provided. Also provided are compositions and formulation for cosmetic uses and methods of maintaining a youthful appearance, reducing an appearance of ageing, inhibiting an appearance of ageing, reducing a rate of an appearance of ageing, reducing a skin inelasticity, reducing a rate of increasing skin inelasticity, maintaining a skin elasticity, and increasing the density of hair follicles of a skin of a subjecl. The uses and methods comprise applying/administering an indoline granzyme B inhibitor to a skin, or a portion of a skin of the subject.

  使用和方法用于在与化妆品可接受载体混合的化合物中使用吲哚啶颗粒酶B抑制剂。提供了用于治疗、减少或抑制皮肤衰老的用途和方法。还提供了用于化妆品用途的组合物和配方，以及保持年轻外观、减少衰老外观、抑制衰老外观、减少衰老外观速率、减少皮肤无弹性、减少增加皮肤无弹性速率、保持皮肤弹性和增加皮肤毛囊密度的方法。这些用途和方法包括将吲哚啶颗粒酶B抑制剂涂抹/施用于皮肤或受试者皮肤的部分。
• Herbicidal glutaramic acids and derivatives
  申请人：Rohm and Haas Company

  公开号：US05238908A1

  公开（公告）日：1993-08-24

  This invention relates to glutaramic acids and derivatives exhibiting herbicidal activity having the structure ##STR1## wherein A is a carboxylic acid or a derivative thereof, D is CH or N, and R, R.sup.1, R.sup.2, T, X, Y, and Z are as defined within, compositions containing these compounds and methods of controlling weeds with these compounds.

  这项发明涉及具有以下结构的表现出除草活性的谷氨酸和衍生物##STR1##其中A是羧酸或其衍生物，D是CH或N，R、R.sup.1、R.sup.2、T、X、Y和Z的定义如内所述，包含这些化合物的组合物以及使用这些化合物控制杂草的方法。
• [EN] NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS<br/>[FR] MODULATEURS DE RECEPTEUR DE PROGESTERONE NON STEROIDES
  申请人：AKZO NOBEL NV

  公开号：WO2003084963A1

  公开（公告）日：2003-10-16

  The present invention provides compounds according to general Formula (I), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a prodrug thereof. More particularly, the present invention provides high affinity non-steroidal compounds which are agonists, partial agonists or antagonists of the progesterone receptor.

  本发明提供了符合一般式（I）的化合物，其前药，其药学上可接受的盐，或其前药的药学上可接受的盐。更具体地，本发明提供了高亲和力的非类固醇化合物，它们是孕激素受体的激动剂、部分激动剂或拮抗剂。
• Herbicidal glutarimides
  申请人：Rohm and Haas Company

  公开号：US05393735A1

  公开（公告）日：1995-02-28

  This invention relates to glutarimide compounds exhibiting herbicidal activity having the structure ##STR1## wherein A is carbonyl, thiocarbonyl or methylene, A.sup.1 is carbonyl or methylene, Q is O or (CH.sub.2).sub.n where n is 0 or 1, D is CH or N and R, R.sup.1, R.sup.2, T, X, Y and Z are as defined within, compositions containing these compounds and methods of using these compounds as herbicides and algicides.

  这项发明涉及具有杀草活性的戊二酰亚胺化合物，其结构为##STR1##其中A是羰基、硫代羰基或亚甲基，A.sup.1是羰基或亚甲基，Q是O或(CH.sub.2).sub.n，其中n为0或1，D是CH或N，R、R.sup.1、R.sup.2、T、X、Y和Z的定义如内所述，包含这些化合物的组合物以及使用这些化合物作为除草剂和杀藻剂的方法。
• Catalytic Preparation of Cyclic Carboxylic Esters
  申请人：Spindler Felix

  公开号：US20090275761A1

  公开（公告）日：2009-11-05

  Preparation of cyclic esters by hydrogenation of a carbonyl group in at least one anhydride radical —C(O)—O—C(O)— of a cyclic dicarboxylic or polycarboxylic anhydride by means of hydrogen in the presence of a homogeneous noble metal catalyst, characterized in that the hydrogenation is carried out in a homogeneous reaction mixture using an iridium catalyst. The cyclic esters are obtained in good chemical and optical yields when prochiral anhydrides are used together with chiral iridium catalysts.

  通过在至少一个环状二羧酸酐基团—C(O)—O—C(O)—中的羰基团上加氢来制备环酯，所述环状二羧酸酐为环状二羧酸酐或多羧酸酐，通过在均相贵金属催化剂存在下使用氢气，在均相反应混合物中使用铱催化剂进行氢化反应。当使用外消旋酸酐与手性铱催化剂一起时，可以获得良好的化学和光学产率。