2-[131I]-iodo-N,N-dimethyltryptamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-[131I]-iodo-N,N-dimethyltryptamine
• 英文别名: 2-(2-(131I)iodanyl-1H-indol-3-yl)-N,N-dimethylethanamine
• 化学式: C₁₂H₁₅IN₂
• 分子量: 318.264
• InChiKey: STCOWIUDUJQPMH-IQTOPCCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  19
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N,N-二甲基色胺 在 sodium hydroxide 、 sodium iodide 、 chloroamine-T 作用下， 以 氯仿 为溶剂， 反应 0.05h， 以81.6%的产率得到2-[131I]-iodo-N,N-dimethyltryptamine
  参考文献：
  名称：

  Synthesis of 131I derivatives of indolealkylamines for brain mapping

  摘要：

  The synthesis and spectral properties of new radioiodinated indolealkylamines like 2-[I-131]-iodo-N,N-dimethyltryptamine, 2-[I-131]-iodo-N-methyltryptamine, 2-[I-131]-iodo-5-methoxy-N,N-dimethyltryptamine, 2-[I-131]-iodo-5-hydroxy-N,N-dimethyltryptamine (2-[I-131]-iodo-bufotenine), and 2-[I-131]-iodo-tryptamine and the known 2-[I-131]-iodo-N-acetyl-5-methoxy-tryptamine (2-[I-131]-iodo-melatonine) are described herein. These were synthesized by a high-yield novel method, and their spectral properties are fully described. These compounds are of biological importance and can be used for brain mapping with SPECT technology.

  DOI：

  10.1002/(sici)1099-1344(199708)39:8<677::aid-jlcr9>3.0.co;2-g

文献信息

• Synthesis of 131I derivatives of indolealkylamines for brain mapping
  作者：Jose A. Sintas、Arturo A. Vitale

  DOI：10.1002/(sici)1099-1344(199708)39:8<677::aid-jlcr9>3.0.co;2-g

  日期：1997.8

  The synthesis and spectral properties of new radioiodinated indolealkylamines like 2-[I-131]-iodo-N,N-dimethyltryptamine, 2-[I-131]-iodo-N-methyltryptamine, 2-[I-131]-iodo-5-methoxy-N,N-dimethyltryptamine, 2-[I-131]-iodo-5-hydroxy-N,N-dimethyltryptamine (2-[I-131]-iodo-bufotenine), and 2-[I-131]-iodo-tryptamine and the known 2-[I-131]-iodo-N-acetyl-5-methoxy-tryptamine (2-[I-131]-iodo-melatonine) are described herein. These were synthesized by a high-yield novel method, and their spectral properties are fully described. These compounds are of biological importance and can be used for brain mapping with SPECT technology.