10-O-BCH-hydroxycamptothecin

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 喜树碱
• 英文名称: 10-O-BCH-hydroxycamptothecin
• 英文别名: [(19S)-19-ethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl] 4-[[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]methyl]cyclohexane-1-carboxylate
• 化学式: C₄₀H₄₂N₄O₉
• 分子量: 722.795
• InChiKey: FNFDFHHTDLKLAB-WWOGWCIBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  53
• 可旋转键数：
  9
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  173
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  10-羟基喜树碱 在 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) 、 N,N-二异丙基乙胺 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 2.25h， 生成 10-O-BCH-hydroxycamptothecin
  参考文献：
  名称：

  WO2007/113687

  摘要：

  公开号：

文献信息

• CAMPTOTHECIN-PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
  申请人：Michel Matthieu

  公开号：US20100015136A1

  公开（公告）日：2010-01-21

  The present invention relates to a novel compound of use in the improved delivery of therapeutic drug agents into target cells or tissues, composition comprising the same and uses thereof. The compound is more specifically a conjugate of a peptide moiety and a camptothecin, a derivative or analog thereof which provides numerous benefits, including enhancement in terms of aqueous solubility, pharmacokinetics and tissue distribution, enlargement of the therapeutic index, and limitation of the inter-patient metabolic variability, as well as improvement of delivery of the biologically active ingredient to the target cells or tissues.
• CAMPTOTHEAN-PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
  申请人：DRAIS PHARMACEUTICALS, INC.

  公开号：US20130244956A1

  公开（公告）日：2013-09-19

  The present invention relates to a novel compound of use in the improved delivery of therapeutic drug agents into target cells or tissues, composition comprising the same and uses thereof. The compound is more specifically a conjugate of a peptidic moiety and a camptothecin, a derivative or analog thereof which provides numerous benefits, including enhancement in terms of aqueous solubility, pharmacokinetics and tissue distribution, enlargement of the therapeutic index, and limitation of the inter-patient metabolic variability, as well as improvement of delivery of the biologically active ingredient to the target cells or tissues.
• US8410045B2
  申请人：——

  公开号：US8410045B2

  公开（公告）日：2013-04-02