2-(2',3-dibromo-4-formyl-phenyl)imidazo[4,5-f][1,10]-phenanthroline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(2',3-dibromo-4-formyl-phenyl)imidazo[4,5-f][1,10]-phenanthroline
• 英文别名: fmp-2Br；2,5-dibromo-4-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)benzaldehyde
• 化学式: C₂₀H₁₀Br₂N₄O
• 分子量: 482.134
• InChiKey: DLRBCWQLAXWXGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2',3-dibromo-4-formyl-phenyl)imidazo[4,5-f][1,10]-phenanthroline 、 ammonium hexafluorophosphate 、 以 甲醇 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Design, synthesis and biological evaluation of liposome entrapped iridium(III) complexes toward SGC-7901 cells

  摘要：

  DOI：

  10.1016/j.jinorgbio.2023.112134
• 作为产物：
  描述：

  1,10-邻二氮杂菲-5,6-二酮 、 2,5-二溴苯-1,4-二甲醛 在 ammonium acetate 、 溶剂黄146 作用下， 以85 %的产率得到2-(2',3-dibromo-4-formyl-phenyl)imidazo[4,5-f][1,10]-phenanthroline
  参考文献：
  名称：

  Design, synthesis and biological evaluation of liposome entrapped iridium(III) complexes toward SGC-7901 cells

  摘要：

  DOI：

  10.1016/j.jinorgbio.2023.112134

文献信息

• DNA binding, photocleavage and topoisomerase inhibitory activity of polypyridyl ruthenium(II) complexes containing the same ancillary ligand and different main ligands
  作者：Xiaojun He、Leli Zeng、Guang Yang、Lingjun Xie、Xiaonan Sun、Lifeng Tan

  DOI：10.1016/j.ica.2013.08.010

  日期：2013.11

  The binding and photocleavage properties of [Ru(phen)(2)L](2+) where phen is 1,10- phenanthroline and L is 2-(4-formylphenyl)imidazo[4,5-f][1,10] phenanthroline (fmp) or 2-(2',3-dibromo-4-formyl-phenyl)imidazo[4,5-f][1,10]-phenanthroline (fmp-2Br)} with regard to DNA were investigated using various biophysical techniques. Results suggest that the two complexes can bind to DNA via an intercalative mode with different affinities and efficiently photocleavage pBR322 DNA in vitro under irradiation. Furthermore, the results of topoisomerase inhibition and DNA strand passage assay reflect that both complexes are efficient dual topoisomerase I and IIa inhibitors. (c) 2013 Elsevier B. V. All rights reserved.
• Design, synthesis and biological evaluation of liposome entrapped iridium(III) complexes toward SGC-7901 cells
  作者：Yichuan Chen、Yiying Gu、Huiyan Hu、Haimei Liu、Wenlong Li、Chunxia Huang、Jing Chen、Lijuan Liang、Yunjun Liu

  DOI：10.1016/j.jinorgbio.2023.112134

  日期：2023.4