(oct-7-en-1-yloxy)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (oct-7-en-1-yloxy)benzene
• 英文别名: Oct-7-enoxybenzene；oct-7-enoxybenzene
• 化学式: C₁₄H₂₀O
• 分子量: 204.312
• InChiKey: LECUFMCKLZHDEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-allyl-2,3,5-tri-O-benzoyl-β-D-galactofuranosyl-(1,6)-2,3,5,6-tetra-O-acetyl-β-D-galactofuranoside 、 (oct-7-en-1-yloxy)benzene 在 Grubbs catalyst first generation 作用下， 以 二氯甲烷 为溶剂， 生成 (2S,3S,4R,5R)-2-((R)-1-(benzoyloxy)-2-(((2R,3R,4S,5S)-3,4-diacetoxy-5-((R)-1,2-diacetoxyethyl)tetrahydrofuran-2-yl)oxy)ethyl)-5-((9-phenoxynon-2-en-1-yl)oxy)tetrahydrofuran-3,4-diyl dibenzoate
  参考文献：
  名称：

  Synthesis of galactofuranose-based acceptor substrates for the study of the carbohydrate polymerase GlfT2

  摘要：

  Despite the prevalence and importance of carbohydrate polymers, the molecular details of their biosynthesis remain elusive. Many enzymes responsible for the synthesis of carbohydrate polymers require a 'primer' or 'initiator' carbohydrate sequence. One example of such an enzyme is the mycobacterial galactofuranosyltransferase GlfT2 (Rv3808c), which generates an essential cell wall building block. We recently demonstrated that recombinant GlfT2 is capable of producing a polymer composed of alternating beta-(1,5) and beta-(1,6)-linked galactofuranose (Galf) residues. Intriguingly, the length of the polymers produced from a synthetic glycosyl acceptor is consistent with those found in the cell wall. To probe the mechanism by which polymer length is controlled, a collection of initiator substrates has been assembled. The central feature of the synthetic route is a ruthenium-catalyzed cross-metathesis as the penultimate transformation. Access to synthetic substrates has led us to postulate a new mechanism for length control in this template-independent polymerization. Moreover, our investigations indicate that lipids possessing but a single galactofuranose residue can act as substrates for GlfT2. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.04.068
• 作为产物：
  描述：

  、 2-丙烯基锂 在 苯甲醛 作用下， 以 乙醚 为溶剂， 反应 2.0h， 以88%的产率得到(oct-7-en-1-yloxy)benzene
  参考文献：
  名称：

  N-（反式-2,3-二苯基叠氮基-1-基）亚胺的阴离子反应及其在阴离子环化中作为1,1-偶极子的用途

  摘要：

  的反应ñ - （反式-2,3- diphenylaziridin -1-基）亚胺用，得到所需的加成产物与芪和氮气的解放沿着连续分片之后烷基锂和有机铜，而反应ñ - （2- phenylaziridin-在类似条件下的1-yl）亚胺产生异常的副产物。使用未活化的烯烃和炔烃作为受体，N-（反式-2,3-二苯基叠氮基-1-基）亚胺的阴离子环化反应顺利进行，从而以高收率得到环化产物。

  DOI：

  10.1002/adsc.200505110

文献信息

• NOXIOUS ARTHROPOD CONTROL AGENT CONTAINING AMIDE COMPOUND
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20170215424A1

  公开（公告）日：2017-08-03

  An object of the present invention is to provide a compound having the controlling activity on a noxious arthropod, and a noxious arthropod controlling agent containing an amide compound of formula (I): wherein X represents a nitrogen atom or a CH group, p represents 0 or 1, A represents a tetrahydrofuranyl group or the like, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 represent a hydrogen atom or the like, n represents 1 or 2, Y represents an oxygen atom or the like, m represents any integer of 0 to 7, and Q represents a C1-8 chain hydrocarbon group optionally having a phenyl group or the like, has the excellent noxious arthropod controlling effect.

  本发明的一个目的是提供一种具有对有害节肢动物的控制活性的化合物，以及含有式（I）的酰胺化合物的有害节肢动物控制剂： 其中X代表氮原子或CH基团，p代表0或1，A代表四氢呋喃基团或类似物，R1、R2、R3、R4、R5、R6和R7代表氢原子或类似物，n代表1或2， Y代表氧原子或类似物，m代表0到7的任意整数，Q代表C1-8链烃基，可选地具有苯基或类似物，具有优异的有害节肢动物控制效果。
• Iron-Catalysedsp3–sp3 Cross-Coupling Reactions of Unactivated Alkyl Halides with Alkyl Grignard Reagents
  作者：Krishna G. Dongol、Huishi Koh、Manisankar Sau、Christina L. L. Chai

  DOI：10.1002/adsc.200600383

  日期：2007.5.7

  Iron-catalysed sp3–sp3 Kumada coupling with primary and secondary alkyl halides (RX) and alkyl Grignard reagents has been achieved in low to good yields depending on the nature of the R group.

  根据R基团的性质，铁催化的sp 3 – sp 3 Kumada与伯，仲烷基卤化物（RX）和烷基Grignard试剂的偶联反应，收率低至好。
• Regioselective Alkoxycarbonylation of Allyl Phenyl Ethers Catalyzed by Pd/dppb Under Syngas Conditions
  作者：Manuel Amézquita-Valencia、Howard Alper

  DOI：10.1021/acs.joc.6b00522

  日期：2016.5.6

  A simple and regioselective synthesis of phenoxy esters and phenylthio esters is reported. The products are obtained by selective alkoxycarbonylation catalyzed by Pd2(dba)3, 1,4-bis(diphenylphisphino)butane (dppb), and syngas (CO/H2) in chloroform/alcohol. This methodology affords bifunctional products in good yield with excellent n-selectivity and without the need to use additives.

  报道了苯氧基酯和苯硫基酯的简单且区域选择性的合成。该产品由通过Pd催化的选择性烷氧基羰基而获得2（DBA）3，1,4-双（diphenylphisphino）丁烷（DPPB）的合成气（CO / H，和2）的氯仿/醇。这种方法可提供双收率好的产品，并具有出色的n选择性，并且无需使用添加剂。
• Diverse Synthesis of Chiral Trifluoromethylated Alkanes via Nickel-Catalyzed Enantioconvergent Reductive Hydroalkylation of Unactivated Olefins
  作者：Wenqing Guo、Li Cheng、Guobin Ma、Weiqi Tong、Fan Wu

  DOI：10.1021/acs.orglett.2c00148

  日期：2022.3.11

  Here, we report a nickel-catalyzed enantioconvergent hydroalkylation of olefins with trifluoromethyl-containing α-alkyl halides for the synthesis of enantioenriched trifluoromethylated alkanes. This reaction employs readily available and bench-stable alkenes as alkyl coupling partners, featuring mild conditions, a broad substrate scope, and high functional group tolerance. The synthetic utility of

  在这里，我们报道了一种镍催化的烯烃与含三氟甲基的α-烷基卤化物的对映收敛加氢烷基化反应，用于合成对映富集的三氟甲基化烷烃。该反应采用容易获得且台式稳定的烯烃作为烷基偶联伙伴，具有条件温和、底物范围广和官能团耐受性高的特点。该方法的合成效用在一系列药物分子和天然产物的后期功能化中得到进一步证明。
• Rhodium-Catalyzed Allylic C–H Functionalization of Unactivated Alkenes with α-Diazocarbonyl Compounds
  作者：Pinki Sihag、Trisha Chakraborty、Masilamani Jeganmohan

  DOI：10.1021/acs.orglett.2c04356

  日期：2023.3.3

  methodology for the allylic C–H alkylation of unactivated alkenes with diazo compounds is demonstrated. The developed protocol is able to bypass the possibility of the cyclopropanation of an alkene upon its reaction with the acceptor–acceptor diazo compounds. The protocol is highly accomplished due to its compatibility with various unactivated alkenes functionalized with different sensitive functional groups

  展示了一种用于未活化烯烃与重氮化合物的烯丙基 C-H 烷基化的氧化还原中性温和方法。开发的方案能够绕过烯烃在与受体-受体重氮化合物反应时发生环丙烷化的可能性。该协议非常完善，因为它与用不同敏感官能团功能化的各种未活化烯烃兼容。合成了一个红环π-烯丙基中间体，并证明它是活性中间体。额外的机理研究有助于阐明可能的反应机制。