Cu(L-asparagine)₂

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Cu(L-asparagine)₂
• 英文别名: Cu(ASN)₂；copper;(2S)-2-aminobutanedioate;(2S)-2-aminobutanedioic acid
• 化学式: C₈H₁₂CuN₂O₈
• 分子量: 327.738
• InChiKey: USXRHOUQEPZFBG-CEOVSRFSSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.93
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  207
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  Cu(L-asparagine)₂ 、 3,3',4,5,5'-pentamethyl-4'-ethyl-2,2'-dipyrrolylmethene 以 N,N-二甲基甲酰胺 为溶剂， 生成 [Cu(aspartic acid(-1H))(3,3',4,5,5'-pentamethyl-4'-ethyl-2,2'-dipyrrolylmethene(-1H))]
  参考文献：
  名称：

  Coordination interactions of alkyl-substituted 2,2′-dipyrrolylmethene derivatives with copper(II) aminoacid complexes

  摘要：

  Using the method of electron spectroscopy we showed that reaction of alkyl-substituted 2,2'-dipyrrolylmethene derivatives with copper(II) aminoacid complexes led to the formation of heteroligand complexes with two chelated metallocycles forming their coordination sphere. Formation constants of the heteroligand complexes were established and their interrelations with the structure of the aminoacid residue side group were elucidated. It was found that alongside the ability to the primary solvolytic dissociation of aminoacid complex, the main effect on the formation of combined coordination sphere of the chelate is defined by the steric factor depending on the structure of substituent in the aminoacid.

  DOI：

  10.1134/s1070363209030232
• 作为产物：
  描述：

  copper(II) choride dihydrate 、 L-天冬酰胺 在 sodium hydroxide 作用下， 生成 Cu(L-asparagine)₂
  参考文献：
  名称：

  Copper(II):phenanthroline complexes with l-asparagine and l-methionine: Synthesis, crystal structure and in-vitro cytotoxic effects on prostate, breast and melanoma cancer cells

  摘要：

  Here we report the cytotoxic effects of the two ternary copper(II) complexes [Cu(Phen)(L-methionine) H2O]Cl center dot 1.5H(2)O (Cu(PHEN)(MET)) and [Cu(Phen)(L-asparagine)H2OCl]H2O (Cu(PHEN)(ASN)), which showed high chemotherapy potential against cancer cells lines. A novel ternary copper(II) complex, Cu (PHEN)(ASN) has been synthesized and its crystalline structure has been determined by single crystal X-ray diffraction. The new complex crystallized in a triclinic system with P-1 space group. The copper (II) center is situated in a trigonal bipyramidal molecular geometry. Both complexes exhibited potent cytotoxic effects against cancer cells lines, killing 100% human melanoma cancer cells line MV3 and 90% human breast cancer cells line MCF7 at a concentration of 50 mu g/ml. Less pronounced but still very good effects were observed for human breast cancer cells line MDA-MB-23 and human prostate cancer cells lines DU-145 and PC3, where both complexes killed about 70% of these cells lines at a concentration of 50 mu g/ml. The Cu(PHEN)(MET) and Cu(PHEN)(ASN) complexes also presented low IC50 values. (C) 2020 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2020.114807

文献信息

• SYNERGISTIC FUNGICIDAL AND ALGICIDAL COMPOSITIONS INCLUDING 2-HYDROXYPHENYLALDEHYDE AND 2-HYDROXYPHENYLKETONE HETEROCYCLOYLHYDRAZONES AND COPPER
  申请人：Shaber Steven Howard

  公开号：US20120045521A1

  公开（公告）日：2012-02-23

  The present invention relates to the use of mixtures containing 2-hydroxyphenylaldehyde and 2-hydroxyphenylketone heterocycloylhydrazone compounds and copper for controlling the growth of fungi and algae.

  本发明涉及使用含有2-羟基苯甲醛和2-羟基苯酮杂环酰腙化合物以及铜来控制真菌和藻类生长的混合物。
• [EN] COPPER SALTS OF ORGANIC ACIDS AND USE THEREOF AS FUNGICIDES<br/>[FR] SELS DE CUIVRE D'ACIDES ORGANIQUES ET LEUR UTILISATION EN TANT QUE FONGICIDE
  申请人：ISAGRO SPA

  公开号：WO2004103074A1

  公开（公告）日：2004-12-02

  Compounds are described, having general formula (I): A . Cu wherein A represents the bibasic ion of an organic acid which can have the meanings (A1) - (A8) and Cu represents the copper 2+ ion; and the use of compounds having formula (I), individually or in a mixture, for the control of bacterial and fungal phytopathogens on vegetables or parts thereof.

  化合物被描述为具有一般式（I）：A . Cu，其中A代表有机酸的二元离子，可以具有意义（A1）-（A8），Cu代表铜2+离子；以及使用具有式（I）的化合物，单独或混合使用，用于控制蔬菜或其部分上的细菌和真菌植物病原体。
• SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER
  申请人：Meyer Stacy T.

  公开号：US20120046170A1

  公开（公告）日：2012-02-23

  The present invention relates to the use of mixtures containing hydrazone compounds and copper for controlling the growth of algae.

  本发明涉及使用含有肼类化合物和铜的混合物来控制藻类的生长。
• SYNERGISTIC FUNGICIDAL AND ALGICIDAL COMPOSITIONS INCLUDING 7-HYDROXY-INDANONE BENZOYLHYDRAZONES AND COPPER
  申请人：Siddall Thomas L.

  公开号：US20120045522A1

  公开（公告）日：2012-02-23

  The present invention relates to the use of mixtures containing 7-hydroxy-indanone benzoylhydrazone compounds and copper for controlling the growth of fungi and algae.

  本发明涉及使用含有7-羟基茚酮苯甲酰腙化合物和铜的混合物来控制真菌和藻类的生长。
• Multifunction "Crown Complexes" from Amino Acids and Peptides for Skin and Hair Restoration
  申请人：Gupta K Shyam

  公开号：US20070099886A1

  公开（公告）日：2007-05-03

  This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2 . The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.

  本发明涉及从氨基酸和羟基芳基烷基酮衍生的席夫碱，或含有该类化合物的植物提取物，其具有图1中的一般化学结构，用于局部应用。本发明还涉及所述席夫碱的某些金属配合物，其在三维化学结构中呈冠状外观，如图2所示。本发明的席夫碱及其金属配合物对于调节金属活化酶和金属酶，例如苯丙氨酸羟化酶、酪氨酸转氨酶、苯丙氨酸转氨酶、酪氨酸酶、各种基质金属蛋白酶、超氧化物歧化酶、5α-还原酶和柠檬酸裂解酶具有用途。此外，它们还适用于多功能局部方法，如美白肌肤、减少皮肤皱纹、抗衰老、胶原蛋白合成、控制痤疮、预防脱发、控制白发和面部油脂控制。