乙烷-1,2-D2 | 5177-70-8

• 分子结构分类: 有机化合物 - 碳氢化合物 - 饱和烃
• 中文名称: 乙烷-1,2-D2
• 英文名称: 1,2-dideuterio-ethane
• 英文别名: 1,2-Dideuterio-aethan；Aethan-1.2-d₂；1.2-Dideutero-aethan；Ethane-1,2-D2；1,2-dideuterioethane
• CAS: 5177-70-8
• 化学式: C₂H₆
• 分子量: 32.0538
• InChiKey: OTMSDBZUPAUEDD-QDNHWIQGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  2
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 magnesium 作用下， 生成 乙烷-1,2-D2
  参考文献：
  名称：

  Injury Severity and Sensitivity to Treatment After Controlled Cortical Impact in Rats

  摘要：

  We sought to determine sensitivity of the cortical impact injury model of traumatic brain injury (TBI) to severity of injury and to treatment. We examined the pattern of motor and cognitive deficits and recovery following TBI over a range of injury severities, and examined the efficacy of surface-induced moderate hypothermia at three disparate injury levels. In experiment I, Sprague-Dawley rats were injured at one of eight injury severity levels from 0 mm (sham) to 2.5 mm depth of penetration. On postinjury day 1, balance beam, rotorod performance, and posture reflexes were evaluated. Motor outcome was increasingly impaired with increasing injury levels, with the pattern of deficits showing a step-like function. Cognitive deficits, assessed using water maze on day 7, were more severe for the 2.5-mm group than for the 1.6-mm injury group, while the 1.0-mm group did not differ from the sham controls. In experiments II-IV, hypothermia, 30 degreesC for 3-h duration or normothermia was applied to three injury levels: 1.0 mm, the least cortical deformation; 2.5 mm, the most deformation; and 1.6 mm, representing a level in-between. Neurologic outcome was assessed relative to shams on postinjury days 1, 3, and 5. The 1.0-mm group exhibited small deficits that recovered completely by day 3; the 1.6-mm group recovered to the level of shams by day 5, and the 2.5-mm group did not show significant recovery during the testing period. Hypothermia effectively attenuated behavioral deficits for the 1.6-mm group, but had no effect on the other two groups. These three observations-that increasing injury severity is associated with increasing motor and cognitive deficits, that injury severity is related to recovery time, and that hypothermia treatment is selectively effective-have each been reported in the human TBI population; thus, moderate cortical impact injury in rats may be a model with clinical predictability for evaluating neuroprotective therapies.

  DOI：

  10.1089/08977150150502604

文献信息

• Reactions of 2-methylpropene and other alkenes on zinc oxide
  作者：Ronald Brown、Charles Kemball、Duncan Taylor

  DOI：10.1039/f19837902899

  日期：——

  Studies have been made on the hydrogenation, deuteration and exchange with deuterium of ethene, propene and 2-methylpropene on zinc oxide and Arrhenius parameters for the reactions have been determined. Some general conclusions are reached about the catalytic behaviour of alkenes on zinc oxide from these and earlier results.

  已经研究了在氧化锌上的乙烯，丙烯和2-甲基丙烯的氘的氢化，氘化和与氘的交换，并且确定了用于反应的Arrhenius参数。从这些和较早的结果可以得出关于烯烃在氧化锌上的催化行为的一些一般性结论。
• Hydrogenation of ethylene over platinum (111) single-crystal surfaces
  作者：F. Zaera、G. A. Somorjai

  DOI：10.1021/ja00320a013

  日期：1984.4

  The hydrogenation of ethylene with both hydrogen and deuterium was studied over (111) platinum single-crystal surfaces under a total pressure of 110 torr and a temperature range of 300-370 K. An activation energy (E/sub a/) of 10.8 +/- 0.1 kcal/mol and kinetic orders with respect to hydrogen and ethylene partial pressure of 1.31 +/- 0.05 and -0.60 +/- 0.05, respectively, were observed. The deuterium

  在 110 托的总压力和 300-370 K 的温度范围内，在 (111) 铂单晶表面上研究了乙烯与氢和氘的氢化反应。 活化能 (E/sub a/) 为 10.8 +观察到氢和乙烯分压分别为 1.31 +/- 0.05 和 -0.60 +/- 0.05 的 /- 0.1 kcal/mol 和动力学级。与 D/sub 2/ 反应的产物中的氘原子分布在每个产生的乙烷分子 1-2 个氘原子处达到峰值，类似于已报道的负载型催化剂。该反应发生在部分有序的碳覆盖表面上，其中碳质沉积物的形态类似于乙炔的形态。但是这种乙炔不直接参与乙烯的加氢，因为它的加氢和氘交换都比乙烷生产慢得多。提出了一种机制来解释实验结果。
• Local reaction environments and their properties for ethene deuterogenation on the surfaces of SMSI catalysts
  作者：Hideaki Yoshitake、Kiyotaka Asakura、Yasuhiro Iwasawa

  DOI：10.1039/f19888404337

  日期：——

  distribution in ethane formed during ethene deuterogenation was also investigated at various reaction temperatures and as a function of the reduction time of the catalyst. By studying the catalysts in their working state instead of by static adsorption measurements two kinds of active sites in different environments are suggested to exist on the surface of these catalysts in the SMSI states. One of these sites

  已经研究了Nb 2 O 5负载的Rh和Ir催化剂上的乙烯氘化和H 2 -D 2交换反应与强金属-载体相互作用（SMSI）现象的关系。这些反应的活化能在Ir / Nb 2 O 5的情况下通过催化剂的高温还原而显着改变，但在Rh / Nb 2 O 5的情况下没有被改变。。这种变化归因于氘解离的能垒的减少。还研究了乙烯在氘化过程中形成的乙烷中氘的分布，该分布在各种反应温度下以及作为催化剂还原时间的函数。通过研究催化剂的工作状态而不是通过静态吸附测量，建议在不同环境中在SMSI状态下在这些催化剂的表面上存在两种活性位点。其中一个站点（站点I）位于裸露的金属表面上，另一个站点（站点II）位于正在迁移的NbO x岛的外围。乙烯氘化过程中氢的表面同位素比率在位置I和II处不同。站点I，其中D 2离解，充当站点II的氘供应。提出了一种在SMSI催化剂上乙烯进行氘代的模型。
• Randell Lee; Whitesides, George M., Journal of the American Chemical Society, 1991, vol. 113, # 7, p. 2576 - 2585
  作者：Randell Lee、Whitesides, George M.

  DOI：——

  日期：——
• Study on d state of platinum in platinum/silica and sodium/platinum/silica catalysts under C:C hydrogenation conditions by x-ray absorption near-edge structure spectroscopy
  作者：Hideaki Yoshitake、Yasuhiro Iwasawa

  DOI：10.1021/j100172a048

  日期：1991.9

  The change in the d-electron density of platinum during D2 + CH2 = CHX reactions on Pt/SiO2 and Na/Pt/SiO2 catalysts and its influence on the catalysis were studied by X-ray absorption near-edge structure (XANES) spectroscopy, kinetics and FT-IR. It was demonstrated from the change of the white lines in XANES spectra at Pt L2 and L3 edges that CH2 = CHX (X = H, CH3, COCH3, CF3, and CN) is adsorbed on the Pt surface and extracts the electrons of the d state. Hence, the deuterogenation rate is reduced as the value of Hammett's sigma-P increases. The linear free energy relationship between the reaction rate and sigma-P was observed for the deuterogenation of CH2 = CHX. The rate of ethene deuterogenation was promoted by Na2O addition. The electron density of unoccupied d states of Pt under vacuum decreased by Na2O addition, indicating the electron donation from Na2O to Pt particles. However, most of these additional electrons were observed to move to ethene under reaction conditions. The acceptor of the electrons was suggested to be di-sigma-ethene by the shift of nu-(C-H). The kinetic parameters are discussed in relation to the change in the d state of Pt as a function of sigma-P and Na quantity.