N-(1-(2,4-dichlorobenzyl)-1,2-dihydro-2-oxonaphtho[2,1-b]furan-1-yl)benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: N-(1-(2,4-dichlorobenzyl)-1,2-dihydro-2-oxonaphtho[2,1-b]furan-1-yl)benzamide
• 英文别名: N-[1-[(2,4-dichlorophenyl)methyl]-2-oxobenzo[e][1]benzofuran-1-yl]benzamide
• 化学式: C₂₆H₁₇Cl₂NO₃
• 分子量: 462.332
• InChiKey: ZPAZRYUYVSHDIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-萘酚 、 4-(2,4-二氯亚苄基)-2-苯基-4H-恶唑-5-酮 在 对甲苯磺酸 作用下， 以 neat (no solvent) 为溶剂， 反应 1.0h， 以73%的产率得到N-(1-(2,4-dichlorobenzyl)-1,2-dihydro-2-oxonaphtho[2,1-b]furan-1-yl)benzamide
  参考文献：
  名称：

  A domino approach for the synthesis of naphtho[2,1-b]furan-2(1H)-ones from azlactones

  摘要：

  A domino approach to naphtho[2,1-b]furan-2(1H)-one derivatives from (Z)-4-arylidene-2-phenyl-5(4)-oxazolones (azlactones) and 2-naphthols catalyzed by p-TSA with reasonably moderate to high yields, has been developed. This protocol illustrates attractive features including a unique and convenient process. (C) 2014 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2014.05.067

文献信息

• A Novel <i>pseudo</i>-Four-Component Domino Reaction for the Synthesis of Naphtho[2,1-<i>b</i>]furan-2(1<i>H</i>)-ones Using a Nanocatalyst
  作者：Elmira Salami-Ranjbaran、Ahmad R. Khosropour、Iraj Mohammadpoor-Baltork、Majid Moghadam、Shahram Tangestaninejad、Valiollah Mirkhani

  DOI：10.1021/acscombsci.5b00018

  日期：2015.8.10

  this article, an original one-pot method is utilized to synthesize a variety of derivatives of naphtho[2,1-b]furan-2(1H)-one via a pseudo-four-component domino reaction of aryl aldehydes, acetic anhydride, hippuric acids, and 2-naphthols catalyzed by [email protected] This reaction illustrates an array of attractive features including, with particular interest in this report, a convenient and unique

  本文采用一种原始的一锅法，通过芳基醛，乙酸的假四组分多米诺反应，合成了各种萘并[ 2,1- b ]呋喃-2（1 H）-one衍生物。[电子邮件保护]催化的酸酐，马尿酸和2-萘酚该反应说明了一系列吸引人的功能，其中包括，在本报告中特别引起关注的是，一种便捷而独特的方法来制备和利用一种强大的可循环利用的纳米催化剂。
• An efficient synthesis of naphtho[2,1-<i>b</i>]furan-2(1<i>H</i>)-ones catalysed by Nafion-H supported on silica-coated super paramagnetic iron oxide nanoparticles
  作者：Mohammad Akrami Abarghooei、Razieh Mohebat、Zahed Karimi-Jaberi、Mohammad Hossein Mosslemin

  DOI：10.3184/174751917x14967701767012

  日期：2017.7

  A one-pot procedure is descibed for the synthesis of naphtho[2,1-b]furan-2(1H)-ones via a multicomponent reaction of aryl aldehydes, hippuric acid, acetic anhydride and β-naphthol in the presence of Nafion-H supported on silica-coated superparamagnetic iron oxide nanoparticles under microwave irradiation. The catalyst can be recovered easily and reused several times without significant loss of catalytic

  描述了通过芳醛、马尿酸、乙酸酐和β-萘酚在Nafion-存在下的多组分反应合成萘并[2,1-b]呋喃-2(1H)-酮的一锅法。 H 在微波辐射下负载在二氧化硅包覆的超顺磁性氧化铁纳米颗粒上。该催化剂可以很容易地回收并重复使用多次，而不会显着降低催化活性。
• A domino approach for the synthesis of naphtho[2,1-b]furan-2(1H)-ones from azlactones
  作者：Elmira Salami-Ranjbaran、Ahmad R. Khosropour、Iraj Mohammadpoor-Baltork

  DOI：10.1016/j.tet.2014.05.067

  日期：2014.12

  A domino approach to naphtho[2,1-b]furan-2(1H)-one derivatives from (Z)-4-arylidene-2-phenyl-5(4)-oxazolones (azlactones) and 2-naphthols catalyzed by p-TSA with reasonably moderate to high yields, has been developed. This protocol illustrates attractive features including a unique and convenient process. (C) 2014 Published by Elsevier Ltd.