esomeprazole piperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: esomeprazole piperazine
• 英文别名: 6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole;piperazine
• 化学式: (x)C₄H₁₀N₂*C₁₇H₁₉N₃O₃S
• 分子量: 431.6
• InChiKey: NJVHEBDQZSVOTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.08
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  120
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  esomeprazole-S-BINOL complex 在 哌啶 、 水 作用下， 以 醋酸异丙酯 、 丙酮 为溶剂， 反应 1.58h， 生成 esomeprazole piperazine
  参考文献：
  名称：

  [EN] PROCESS FOR THE RESOLUTION OF OMEPRAZOLE
  [FR] PROCÉDÉ DE DÉDOUBLEMENT DE L'OMÉPRAZOLE

  摘要：

  本发明涉及奥美拉唑的分离工艺。本发明还提供了奥美拉唑环状胺盐对映体的新化合物及其制备方法。本发明还提供了(R)-或(S)-奥美拉唑环状胺盐的固体及其制备方法。本发明还提供了一种制备基本不含其三水合物形式的埃索美拉唑镁二水合物的方法。本发明还提供了一种手性BINOL的制备或回收方法。

  公开号：

  WO2011058569A1

文献信息

• PROCESS FOR THE RESOLUTION OF OMEPRAZOLE
  申请人：Parthasaradhi Reddy Bandi

  公开号：US20120215003A1

  公开（公告）日：2012-08-23

  The present invention relates to process for the resolution of omeprazole. The present invention further provides a novel compound of enantiomers of omeprazole cyclic amine salt and a process for preparing it. The present invention also provides a solid of (R)- or (S)-omeprazole cyclic amine salt and a process for preparing it. The present invention also provides a process for the preparation of esomeprazole magnesium dihydrate substantially free of its trihydrate form. The present invention also provides a process for the preparation of recovery of chiral BINOL.

  本发明涉及奥美拉唑的分离过程。本发明还提供了一种新型的奥美拉唑环胺盐对映体化合物及其制备方法。本发明还提供了(R)-或(S)-奥美拉唑环胺盐的固体及其制备方法。本发明还提供了一种制备基本不含三水合物的埃索美拉唑镁二水合物的方法。本发明还提供了一种手性BINOL的制备或回收方法。
• Process for the resolution of omeprazole
  申请人：Parthasaradhi Reddy Bandi

  公开号：US08748619B2

  公开（公告）日：2014-06-10

  The present invention relates to process for the resolution of omeprazole. The present invention further provides a novel compound of enantiomers of omeprazole cyclic amine salt and a process for preparing it. The present invention also provides a solid of (R)- or (S)-omeprazole cyclic amine salt and a process for preparing it. The present invention also provides a process for the preparation of esomeprazole magnesium dihydrate substantially free of its trihydrate form. The present invention also provides a process for the preparation of recovery of chiral BINOL.

  本发明涉及一种奥美拉唑的分离工艺。本发明还提供了一种新的奥美拉唑环状胺盐对映体化合物及其制备工艺。本发明还提供了(R)-或(S)-奥美拉唑环状胺盐的固体及其制备工艺。本发明还提供了一种制备基本不含其三水合物的埃索美拉唑镁二水合物的工艺。本发明还提供了一种手性BINOL的制备或回收工艺。
• [EN] PROCESS FOR THE RESOLUTION OF OMEPRAZOLE<br/>[FR] PROCÉDÉ DE DÉDOUBLEMENT DE L'OMÉPRAZOLE
  申请人：HETERO RESEARCH FOUNDATION

  公开号：WO2011058569A1

  公开（公告）日：2011-05-19

  The present invention relates to process for the resolution of omeprazole. The present invention further provides a novel compound of enantiomers of omeprazole cyclic amine salt and a process for preparing it. The present invention also provides a solid of (R)- or (S)-omeprazole cyclic amine salt and a process for preparing it. The present invention also provides a process for the preparation of esomeprazole magnesium dihydrate substantially free of its trihydrate form. The present invention also provides a process for the preparation of recovery of chiral BINOL.

  本发明涉及奥美拉唑的分离工艺。本发明还提供了奥美拉唑环状胺盐对映体的新化合物及其制备方法。本发明还提供了(R)-或(S)-奥美拉唑环状胺盐的固体及其制备方法。本发明还提供了一种制备基本不含其三水合物形式的埃索美拉唑镁二水合物的方法。本发明还提供了一种手性BINOL的制备或回收方法。