3-amino-hex-4-enoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-amino-hex-4-enoic acid
• 英文别名: 2-Amino-penten-(3)-carbonsaeure-(1)；Aminodihydrosorbinsaeure；3-Amino-hex-4-ensaeure；(E)-3-aminohex-4-enoic acid
• 化学式: C₆H₁₁NO₂
• 分子量: 129.159
• InChiKey: JIYMEWDAMJBYNZ-NSCUHMNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-amino-hex-4-enoic acid 、 苯甲酰氯 在 sodium hydroxide 作用下， 生成 3-benzoylamino-hex-4-enoic acid
  参考文献：
  名称：

  Posner; Rohde, Chemische Berichte, 1910, vol. 43, p. 2675

  摘要：

  DOI：
• 作为产物：
  描述：

  山梨酸甲酯 在 甲醇 、 羟胺 作用下， 生成 3-amino-hex-4-enoic acid
  参考文献：
  名称：

  Posner; Rohde, Chemische Berichte, 1910, vol. 43, p. 2675

  摘要：

  DOI：

文献信息

• SEMI-SYNTHETIC TEREPHTHALIC ACID VIA MICROORGANISMS THAT PRODUCE MUCONIC ACID
  申请人：Burk Mark J.

  公开号：US20110124911A1

  公开（公告）日：2011-05-26

  The invention provides a non-naturally occurring microbial organism having a muconate pathway having at least one exogenous nucleic acid encoding a muconate pathway enzyme expressed in a sufficient amount to produce muconate. The muconate pathway including an enzyme selected from the group consisting of a beta-ketothiolase, a beta-ketoadipyl-CoA hydrolase, a beta-ketoadipyl-CoA transferase, a beta-ketoadipyl-CoA ligase, a 2-fumarylacetate reductase, a 2-fumarylacetate dehydrogenase, a trans-3-hydroxy-4-hexendioate dehydratase, a 2-fumarylacetate aminotransferase, a 2-fumarylacetate aminating oxidoreductase, a trans-3-amino-4-hexenoate deaminase, a beta-ketoadipate enol-lactone hydrolase, a muconolactone isomerase, a muconate cycloisomerase, a beta-ketoadipyl-CoA dehydrogenase, a 3-hydroxyadipyl-CoA dehydratase, a 2,3-dehydroadipyl-CoA transferase, a 2,3-dehydroadipyl-CoA hydrolase, a 2,3-dehydroadipyl-CoA ligase, a muconate reductase, a 2-maleylacetate reductase, a 2-maleylacetate dehydrogenase, a cis-3-hydroxy-4-hexendioate dehydratase, a 2-maleylacetate aminoatransferase, a 2-maleylacetate aminating oxidoreductase, a cis-3-amino-4-hexendioate deaminase, and a muconate cis/trans isomerase. Other muconate pathway enzymes also are provided. Additionally provided are methods of producing muconate.

  本发明提供了一种非自然存在的微生物有着至少一个外源核酸编码的足量表达黏酸途径酶以产生黏酸的黏酸途径微生物。黏酸途径包括以下酶的选择：β-酮巯基硫酰酶、β-酮己二酸-CoA水解酶、β-酮己二酸-CoA转移酶、β-酮己二酸-CoA连接酶、2-富马酰乙酸还原酶、2-富马酰乙酸脱氢酶、顺式-3-羟基-4-己烯二酸脱水酶、2-富马酰乙酸氨基转移酶、2-富马酰乙酸氨基氧化还原酶、顺式-3-氨基-4-己烯二酸脱氨酶、β-酮己二酸烯醇内酯水解酶、黏酸内酯异构酶、黏酸环异构酶、β-酮己二酸-CoA脱氢酶、3-羟基己二酰-CoA脱水酶、2,3-脱氢己二酰-CoA转移酶、2,3-脱氢己二酰-CoA水解酶、2,3-脱氢己二酰-CoA连接酶、黏酸还原酶、2-马来酰乙酸还原酶、2-马来酰乙酸脱氢酶、顺式-3-羟基-4-己烯二酸脱水酶、2-马来酰乙酸氨基转移酶、2-马来酰乙酸氨基氧化还原酶、顺式-3-氨基-4-己烯二酸脱氨酶和黏酸顺/反异构酶。还提供了其他黏酸途径酶。此外，还提供了生产黏酸的方法。
• [EN] SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS hPPAR GAMMA AND hPPAR ALPHA ACTIVATORS<br/>[FR] OXAZOLES SUBSTITUES ET DERIVES DE THIAZOLES COMME ACTIVATEURS DE ALPHA hPPAR ET DE GAMMA hPPAR
  申请人：GLAXO GROUP LTD

  公开号：WO2000008002A1

  公开（公告）日：2000-02-17

  The present invention discloses compounds of formula (I), and tautomeric forms, pharmaceutically acceptable salts, or solvates thereof. Preferably, the compounds of the invention are dual activators of hPPARη and hPPARα.

  本发明揭示了公式（I）的化合物，以及其互变异构体、药学上可接受的盐或溶剂。优选地，本发明的化合物是hPPARη和hPPARα的双激活剂。
• Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
  申请人：GENOMATICA, INC.

  公开号：US10041093B2

  公开（公告）日：2018-08-07

  The invention provides a non-naturally occurring microbial organism having a muconate pathway having at least one exogenous nucleic acid encoding a muconate pathway enzyme expressed in a sufficient amount to produce muconate. The muconate pathway including an enzyme selected from the group consisting of a beta-ketothiolase, a beta-ketoadipyl-CoA hydrolase, a beta-ketoadipyl-CoA transferase, a beta-ketoadipyl-CoA ligase, a 2-fumarylacetate reductase, a 2-fumarylacetate dehydrogenase, a trans-3-hydroxy-4-hexendioate dehydratase, a 2-fumarylacetate aminotransferase, a 2-fumarylacetate aminating oxidoreductase, a trans-3-amino-4-hexenoate deaminase, a beta-ketoadipate enol-lactone hydrolase, a muconolactone isomerase, a muconate cycloisomerase, a beta-ketoadipyl-CoA dehydrogenase, a 3-hydroxyadipyl-CoA dehydratase, a 2,3-dehydroadipyl-CoA transferase, a 2,3-dehydroadipyl-CoA hydrolase, a 2,3-dehydroadipyl-CoA ligase, a muconate reductase, a 2-maleylacetate reductase, a 2-maleylacetate dehydrogenase, a cis-3-hydroxy-4-hexendioate dehydratase, a 2-maleylacetate aminoatransferase, a 2-maleylacetate aminating oxidoreductase, a cis-3-amino-4-hexendioate deaminase, and a muconate cis/trans isomerase. Other muconate pathway enzymes also are provided. Additionally provided are methods of producing muconate.

  本发明提供了一种具有粘液酸盐途径的非天然微生物有机体，该有机体具有至少一种编码粘液酸盐途径酶的外源核酸，其表达量足以产生粘液酸盐。粘液酸盐途径包括一种酶，该酶选自以下组成的组 β-酮硫醇酶、β-酮基二烯丙基-CoA 水解酶、β-酮基二烯丙基-CoA 转移酶、β-酮基二烯丙基-CoA 连接酶、2-富马酸乙酸酯还原酶、2-富马酸乙酸酯脱氢酶、反式-3-羟基-4-己烯酸脱水酶、2-富马酸氨基转移酶、2-富马酸氨化氧化还原酶、反式-3-氨基-4-己烯酸脱氨酶、β-酮基己二酸烯醇-内酯水解酶、粘蛋白内酯异构酶、木糖醛酸环异构酶、β-酮基二烯丙基-CoA 脱氢酶、3-羟基二烯丙基-CoA 脱水酶、2,3-脱氢二烯丙基-CoA 转移酶、2,3-脱氢二烯丙基-CoA 水解酶、2,3-脱氢二烯丙基-CoA 连接酶、木糖醛酸还原酶、2-马来酰乙酸还原酶、2-马来酰乙酸脱氢酶、顺式-3-羟基-4-己二酸脱水酶、2-马来酰乙酸氨基转移酶、2-马来酰乙酸氨基氧化还原酶、顺式-3-氨基-4-己二酸脱氨酶和丙二酸顺式/反式异构酶。还提供了其他粘菌酸途径酶。此外，还提供了生产粘菌酸的方法。
• SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1102757A1

  公开（公告）日：2001-05-30
• US9562241B2
  申请人：——

  公开号：US9562241B2

  公开（公告）日：2017-02-07