N-formyl-L-serine methyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-formyl-L-serine methyl ester
• 英文别名: N-formyl Ser-OMe；methyl (2S)-2-formamido-3-hydroxypropanoate
• 化学式: C₅H₉NO₄
• 分子量: 147.131
• InChiKey: IZVCPGPZIFSYPN-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲酸 、 L-丝氨酸甲酯盐酸盐 在 N-甲基吗啉 作用下， 以 二氯甲烷 为溶剂， 以80%的产率得到N-formyl-L-serine methyl ester
  参考文献：
  名称：

  Capsicum annuum Fruit Extract: A Novel Reducing Agent for the Green Synthesis of ZnO Nanoparticles and Their Multifunctional Applications

  摘要：

  A simple, efficient and convenient method for the preparation of zinc oxide (ZnO) nanoparticle was described. Several parameters like size and morphology of the prepared nanoparticles were characterized thorough a variety of analytical techniques such as XRD, FT-IR, UV-Vis, SEM, and EDX. The prepared ZnO nanoparticles were successfully used as catalyst for the formylation of amino acid esters and biodiesel synthesis. Further, the synthesized formamide esters were well characterized through HRMS, H-1 NMR and C-13 NMR analysis and subjected for the in vitro antibacterial and antifungal tests and the results indicated that some of them showed promising activity against targeted bacterial pathogens.

  DOI：

  10.17344/acsi.2017.4034

文献信息

• A Facile Procedure for the Synthesis of<i>N</i>-Formyl Amino Acid Esters
  作者：T. Chancellor、Charles Morton

  DOI：10.1055/s-1994-25628

  日期：——

  A variety of amino acid ester hydrochlorides react with triethyl orthoformate (TEOF) or trimethyl orthoformate (TMOF) to give the N-formyl amino acid ester in good yield and high optical purity.

  各种氨基酸酯盐酸盐与三乙基甲酸酯（TEOF）或三甲基甲酸酯（TMOF）反应，能够高产率和高光学纯度地得到N-甲酰氨基酸酯。