(l)-HO2C(CH2)20C(O)NH(CH2)3CH(NH2)CO2H

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (l)-HO2C(CH2)20C(O)NH(CH2)3CH(NH2)CO2H
• 英文别名: (l)-C22Orn；22-[[(4S)-4-amino-4-carboxybutyl]amino]-22-oxodocosanoic acid
• 化学式: C₂₇H₅₂N₂O₅
• 分子量: 484.72
• InChiKey: FPXOILODAOJDEH-DEOSSOPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  34
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  copper diacetate 、 lead acetate 、 (l)-HO2C(CH2)20C(O)NH(CH2)3CH(NH2)CO2H 在 TFA 作用下， 以 氯仿 、 水 为溶剂， 生成 [(l)-O2C(CH2)20C(O)NH(CH2)3CH(NH2)CO2)2CuPb
  参考文献：
  名称：

  水相上多层膜中的晶体波纹

  摘要：

  在一系列不同长度的双功能双亲性亲双性分子的自组装超分子复合物中，在异常界面上检测到一个强布拉格峰，这归因于结晶膜中的规则波纹。该峰的d间距是建议的波纹重复长度ca的一半。82Å，不是晶体结构的长晶格间距的倍数，并且容易受到薄膜压缩的影响。这种波纹是根据极性两性表面的极性水表面与非两亲性非极性烃类之间的不利相互作用来解释的。为了确定波纹的性质，应用了带有同步加速器辐射的掠入射X射线衍射和镜面X射线反射率，以及沉积在云母上的薄膜的扫描力显微镜。

  DOI：

  10.1002/hlca.200390221
• 作为产物：
  描述：

  (S)-ornithine methyl ester 在 氢氧化钾 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 生成 (l)-HO2C(CH2)20C(O)NH(CH2)3CH(NH2)CO2H
  参考文献：
  名称：

  Self-Assembly of Bolaamphiphiles Forming Alternating Layer Arrangements with Lead and Copper Divalent Ions

  摘要：

  Five bifunctional alpha -amino acid-epsilon -carboxy bolaamphiphiles [(2-RS, or RS)-(HOOC)-(CH2)(m)-CONH-(CH2)(n)-CH(COOH)(NH2) m=20,22, n=3,4 labeled (l), (d,l)-C(22)Orn (l), (d), (d,l)-C(22)Lys, (d,l)-C(24)Lys respectively] were synthesized. These molecules were deposited on different aqueous subphases, and studied by means of grazing incidence X-ray diffraction (GIXD). On deionized water, the bolaamphiphiles (dl)-C(22)Lys yield a mixture of crystallites: both a monolayer, in which the chains are tilted from the normal, and a multilayer in which the molecules lie parallel to the water. On the other hand, when deposited on mono- or bi-metal ionic subphases, they self-assemble into crystalline multilayer films in which the molecules lie parallel to the aqueous solution surface, linked head-to-head and tail-to-tail in the form of extended chains. The latter are juxtaposed such that the metal ions form sheets separated by the organic molecules, aligned perpendicular to the plane of the aqueous solution. Deposition of either the enantiomerically pure or racemic bifunctional bolaamphiphiles on an aqueous solution of mixed Cu(Acetate)(2) and Pb(Acetate)(2), yields self-assembled crystalline films composed of the two different metal cations, arranged in alternating sheets, separated by the organic spacer. Both GIXD and X-ray-photoelectric-spectroscopy (XPS) studies (after deposition on solid support) demonstrate that the structures of these films differ form the ones formed on either pure Pb(Ac)(2) or on Cu(AC)(2) solutions, thus excluding the simultaneous formation of the two monometallic crystalline phases.

  DOI：

  10.1021/jp0116508

文献信息

• Self-Assembly of Bolaamphiphiles Forming Alternating Layer Arrangements with Lead and Copper Divalent Ions
  作者：R. Buller、Hagai Cohen、T. R. Jensen、K. Kjaer、M. Lahav、L. Leiserowitz

  DOI：10.1021/jp0116508

  日期：2001.11.1

  Five bifunctional alpha -amino acid-epsilon -carboxy bolaamphiphiles [(2-RS, or RS)-(HOOC)-(CH2)(m)-CONH-(CH2)(n)-CH(COOH)(NH2) m=20,22, n=3,4 labeled (l), (d,l)-C(22)Orn (l), (d), (d,l)-C(22)Lys, (d,l)-C(24)Lys respectively] were synthesized. These molecules were deposited on different aqueous subphases, and studied by means of grazing incidence X-ray diffraction (GIXD). On deionized water, the bolaamphiphiles (dl)-C(22)Lys yield a mixture of crystallites: both a monolayer, in which the chains are tilted from the normal, and a multilayer in which the molecules lie parallel to the water. On the other hand, when deposited on mono- or bi-metal ionic subphases, they self-assemble into crystalline multilayer films in which the molecules lie parallel to the aqueous solution surface, linked head-to-head and tail-to-tail in the form of extended chains. The latter are juxtaposed such that the metal ions form sheets separated by the organic molecules, aligned perpendicular to the plane of the aqueous solution. Deposition of either the enantiomerically pure or racemic bifunctional bolaamphiphiles on an aqueous solution of mixed Cu(Acetate)(2) and Pb(Acetate)(2), yields self-assembled crystalline films composed of the two different metal cations, arranged in alternating sheets, separated by the organic spacer. Both GIXD and X-ray-photoelectric-spectroscopy (XPS) studies (after deposition on solid support) demonstrate that the structures of these films differ form the ones formed on either pure Pb(Ac)(2) or on Cu(AC)(2) solutions, thus excluding the simultaneous formation of the two monometallic crystalline phases.
• Crystalline Corrugation in Multilayer Films on Aqueous Subphases
  作者：R. Buller、I. Weissbuch、S. Cohen、K. Kjaer、M. Lahav、L. Leiserowitz

  DOI：10.1002/hlca.200390221

  日期：2003.8

  susceptible to film compression. This corrugation is interpreted in terms of unfavorable interactions between the polar aqueous surface and the nonpolar hydrocarbon part of the bolaamphiphiles. To establish the nature of the corrugation, grazing-incidence X-ray diffraction and specular X-ray reflectivity with synchrotron radiation were applied, as well as scanning force microscopy of films deposited on

  在一系列不同长度的双功能双亲性亲双性分子的自组装超分子复合物中，在异常界面上检测到一个强布拉格峰，这归因于结晶膜中的规则波纹。该峰的d间距是建议的波纹重复长度ca的一半。82Å，不是晶体结构的长晶格间距的倍数，并且容易受到薄膜压缩的影响。这种波纹是根据极性两性表面的极性水表面与非两亲性非极性烃类之间的不利相互作用来解释的。为了确定波纹的性质，应用了带有同步加速器辐射的掠入射X射线衍射和镜面X射线反射率，以及沉积在云母上的薄膜的扫描力显微镜。