Trt-D-Phe-Gly-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Trt-D-Phe-Gly-OH
• 英文别名: 2-[[(2R)-3-phenyl-2-(tritylamino)propanoyl]amino]acetic acid
• 化学式: C₃₀H₂₈N₂O₃
• 分子量: 464.564
• InChiKey: IQGJBKXBGXTKKO-HHHXNRCGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Trt-D-Phe-Gly-OH 在 N-羟基丁二酰亚胺 、 N,N'-二环己基碳二亚胺 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Structure–activity relationships of carboxymethylpullulan-peptide-doxorubicin conjugates—systematic modification of peptide spacers

  摘要：

  A series of carboxymethylpullulan (CMPul)-doxorubicin (DXR) conjugates bound by peptide spacers of different compositions and lengths were prepared and evaluated for their in vivo antitumor effects. Systematic study of the peptide spacers indicated that CMPul-DXR conjugates bound via appropriate dipeptide spacers were more potent than DXR. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00678-2

文献信息

• Structure–activity relationships of carboxymethylpullulan-peptide-doxorubicin conjugates—systematic modification of peptide spacers
  作者：Hideo Nogusa、Toshiro Yano、Nobukazu Kashima、Keiji Yamamoto、Satoshi Okuno、Hiroshi Hamana

  DOI：10.1016/s0960-894x(99)00678-2

  日期：2000.2

  A series of carboxymethylpullulan (CMPul)-doxorubicin (DXR) conjugates bound by peptide spacers of different compositions and lengths were prepared and evaluated for their in vivo antitumor effects. Systematic study of the peptide spacers indicated that CMPul-DXR conjugates bound via appropriate dipeptide spacers were more potent than DXR. (C) 2000 Elsevier Science Ltd. All rights reserved.